X0407 4 2023-03-17 0 0001628171 Revolution Medicines, Inc. RVMD 0001462808 Kelsey Stephen Michael C/O REVOLUTION MEDICINES, INC. 700 SAGINAW DRIVE REDWOOD CITY CA 94063 0 1 0 0 See Remarks 0 Common Stock 2023-03-17 4 S 0 1230 21.78 D 326369 D Pursuant to an automatic sell-to-cover imposed by the terms of the restricted stock units ("RSUs") award, the shares were sold following the vesting of the RSUs solely to cover applicable withholding taxes. This transaction was executed in multiple trades in prices ranging from $21.4115 to $21.784581, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote. Includes 76,600 RSUs. President, Research and Development /s/ Jack Anders, as Attorney-in-fact for Stephen Michael Kelsey 2023-03-21