<?xml version="1.0" encoding="UTF-8"?><own:edgarSubmission xmlns:com="http://www.sec.gov/edgar/common" xmlns:own="http://www.sec.gov/edgar/ownership">
  <!-- Generated by Workiva -->
  <own:headerData>
    <own:submissionType>144</own:submissionType>
    <own:filerInfo>
      <own:filer>
        <own:filerCredentials>
          <own:cik>0001628098</own:cik>
          <own:ccc>XXXXXXXX</own:ccc>
        </own:filerCredentials>
      </own:filer>
      <own:liveTestFlag>LIVE</own:liveTestFlag>



    </own:filerInfo>
  </own:headerData>
  <own:formData>
    <own:issuerInfo>
      <own:issuerCik>0001816736</own:issuerCik>
      <own:issuerName>Disc Medicine, Inc.</own:issuerName>
      <own:secFileNumber>001-39438</own:secFileNumber>
      <own:issuerAddress>
        <com:street1>321 ARSENAL STREET, SUITE 101</com:street1>
        <com:city>WATERTOWN</com:city>
        <com:stateOrCountry>MA</com:stateOrCountry>
        <com:zipCode>02472</com:zipCode>
      </own:issuerAddress>
      <own:issuerContactPhone>617-674-9274</own:issuerContactPhone>
      <own:nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Atlas Venture Fund X, LP</own:nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <own:relationshipsToIssuer>
        <own:relationshipToIssuer>Shareholder</own:relationshipToIssuer>
      </own:relationshipsToIssuer>
    </own:issuerInfo>
    <own:securitiesInformation>
      <own:securitiesClassTitle>Common Stock</own:securitiesClassTitle>
      <own:brokerOrMarketmakerDetails>
        <own:name>Merrill Lynch</own:name>
        <own:address>
          <com:street1>One Bryant Park</com:street1>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10036</com:zipCode>
        </own:address>
      </own:brokerOrMarketmakerDetails>
      <own:noOfUnitsSold>2212</own:noOfUnitsSold>
      <own:aggregateMarketValue>175566.44</own:aggregateMarketValue>
      <own:noOfUnitsOutstanding>38392844</own:noOfUnitsOutstanding>
      <own:approxSaleDate>09/04/2026</own:approxSaleDate>
      <own:securitiesExchangeName>Nasdaq</own:securitiesExchangeName>
    </own:securitiesInformation>
    <own:securitiesToBeSold>
      <own:securitiesClassTitle>Common Stock</own:securitiesClassTitle>
      <own:acquiredDate>05/01/2020</own:acquiredDate>
      <own:natureOfAcquisitionTransaction>Private Placement</own:natureOfAcquisitionTransaction>
      <own:nameOfPersonfromWhomAcquired>Issuer</own:nameOfPersonfromWhomAcquired>
      <own:isGiftTransaction>N</own:isGiftTransaction>
      <own:amountOfSecuritiesAcquired>2212</own:amountOfSecuritiesAcquired>
      <own:paymentDate>05/01/2020</own:paymentDate>
      <own:natureOfPayment>Cash</own:natureOfPayment>
    </own:securitiesToBeSold>
    <own:nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</own:nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <own:remarks>See attached Table II for sales of securities over the last three months.</own:remarks>
    <own:noticeSignature>
      <own:noticeDate>09/04/2026</own:noticeDate>
      <own:signature>Ommer Chohan</own:signature>
    </own:noticeSignature>
  </own:formData>

</own:edgarSubmission>
