X0306 4 2017-03-08 0 0001404644 AQUINOX PHARMACEUTICALS, INC AQXP 0001627684 Mitchell David Chilton C/O AQUINOX PHARMACEUTICALS, INC. 450 - 887 GREAT NORTHERN WAY VANCOUVER A1 V5T 4T5 BRITISH COLUMBIA, CANADA 0 1 0 0 VP Global Regulatory & Quality Stock Option (Right to Buy) 17.35 2017-03-08 4 A 0 25000 0.00 A 2027-03-07 Common Stock 25000 25000 D The shares subject to this option shall vest and become exercisable at a rate of twenty-five percent of the total number of shares underlying the options on the one-year anniversary of March 8, 2017 (the "Vesting Commencement Date") and 1/48th of the total number of shares underlying the options each monthly anniversary of the vesting commencement date thereafter for so long as the recipient of the option provides continuous service to the issuer, such that the total number of shares underlying the options shall be fully vested on the four-year anniversary of the vesting commencement date. /s/ Kamran Alam, Attorney-in-fact 2017-03-10