Related Party Transactions (Tables)

12 Months Ended

Dec. 31, 2024

Related Party Transactions

Schedule of common stock sold to related parties

	Number of		Number of		Number of		Aggregate
		Shares of	Pre-Funded		Common		Purchase
	Common Stock		Warrants		Warrants		Price
OrbiMed Advisors LLC (1)		—		1,444,085		1,397,684	$	2,499,856
Puissance Capital Management (2)		866,451		—		838,610		1,500,000
Richard A. Miller, M.D. (3)		577,634		—		559,073		1,000,000
William B. Jones, Ph.D. (4)		20,001		—		19,358		34,624

(2) Peter Thompson, M.D., a member of our Board of Directors since November 2014, is a Member of OrbiMed Advisors, LLC.

(3) Ted Wang, Ph.D., a Co-Founder, General Manager and Director of Angel Pharmaceuticals, of which the Company holds a 49.7% ownership interest, is the founder of Puissance Capital Management.

(4) Richard A. Miller, M.D. is the Company’s President, Chief Executive Officer and Chairman of the Board.

(5) William B. Jones, Ph.D. is the Company’s Senior Vice President, Pharmaceutical Development.