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Related Party Transactions (Details)
1 Months Ended 3 Months Ended 9 Months Ended
Apr. 26, 2016
$ / shares
shares
Aug. 31, 2021
ft²
Feb. 28, 2021
USD ($)
$ / shares
shares
Mar. 31, 2018
USD ($)
$ / shares
shares
Sep. 30, 2022
USD ($)
Sep. 30, 2021
USD ($)
Sep. 30, 2022
USD ($)
Sep. 30, 2021
USD ($)
Dec. 31, 2021
Public Offerings                  
Proceeds from sale of stock               $ 31,989,000  
Owners of More Than 5% of Our Common Stock or Board of Directors                  
Area of property subleased | ft²   7,585              
Sublease income - related party         $ 147,000 $ 94,000 $ 439,000 94,000  
Angel Pharmaceuticals                  
Owners of More Than 5% of Our Common Stock or Board of Directors                  
Area of property subleased | ft²   7,585              
Sublease income - related party         $ 146,000   440,000    
ICON plc                  
Owners of More Than 5% of Our Common Stock or Board of Directors                  
Clinical trial expense             $ 330,000 205,000  
Follow On Public Offering                  
Public Offerings                  
Issuance of common stock (in shares) | shares     9,783,660 8,117,647          
Share offering price | $ / shares     $ 3.50 $ 8.50          
Proceeds from sale of stock     $ 32,000,000.0 $ 64,900,000          
Follow On Public Offering | Orbimed Advisors LLC                  
Public Offerings                  
Issuance of common stock (in shares) | shares     1,285,714            
Owners of More Than 5% of Our Common Stock or Board of Directors                  
Aggregate Purchase Price     $ 4,499,999            
Follow On Public Offering | Richard A. Miller, M.D.                  
Public Offerings                  
Issuance of common stock (in shares) | shares     100,000            
Owners of More Than 5% of Our Common Stock or Board of Directors                  
Aggregate Purchase Price     $ 350,000            
Over-Allotment Option                  
Public Offerings                  
Issuance of common stock (in shares) | shares 502,618   1,212,231 1,058,823          
Share offering price | $ / shares $ 15.00                
Angel Pharmaceuticals                  
Related Party Transactions                  
Ownership interest (as percent)         49.70%   49.70%   49.70%
Angel Pharmaceuticals | Angel Pharmaceuticals                  
Related Party Transactions                  
Ownership interest (as percent)                 49.70%
Owners of More Than 5% of Our Common Stock or Board of Directors                  
Internal personnel costs             $ 140,000 167,000  
Third-party costs             $ 631,000 $ 470,000