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License and Collaboration Agreements (Details)
1 Months Ended 3 Months Ended
May 31, 2017
item
Mar. 31, 2019
USD ($)
Feb. 28, 2017
USD ($)
Dec. 31, 2016
USD ($)
Feb. 28, 2015
USD ($)
Licensing Agreement | Scripps Research Institute          
License and Collaboration Agreements          
Minimum annual fee       $ 25,000  
Aggregate potential milestone payments   $ 2,600,000      
Milestone payments made   $ 0      
Period of written notice to terminate   90 days      
Licensing Agreement | Scripps Research Institute | Research and development          
License and Collaboration Agreements          
One-time cash payment       $ 10,000  
Licensing Agreement | Vernalis (R&D) Limited          
License and Collaboration Agreements          
Milestone payments made     $ 3,000,000    
Period of written notice to terminate   90 days      
Licensing Agreement | Vernalis (R&D) Limited | Minimum          
License and Collaboration Agreements          
Aggregate potential milestone payments   $ 220,000,000      
Licensing Agreement | Vernalis (R&D) Limited | Research and development          
License and Collaboration Agreements          
One-time cash payment         $ 1,000,000
Clinical Trial Collaboration Agreement | Genentech          
License and Collaboration Agreements          
Maximum number of patients in treatment arm under collaboration agreement | item 65