X0306 4/A 2015-12-16 2015-12-22 0 0001626878 XBiotech Inc. xbit 0001638986 HAN QUEENA 8201 E RIVERSIDE DRIVE BLDG 4 STE 100 AUSTIN TX 78744 0 1 0 0 VP Finance / HR Common Shares 2015-12-18 4 M 0 10000 0.72 A 10000 D Common Shares 2015-12-18 4 S 0 7700 10.51 D 2300 D Common Shares 2015-12-18 4 S 0 2300 11.055 D 0 D Common Shares 2015-12-21 4 M 0 10000 0.72 A 10000 D Common Shares 2015-12-21 4 S 0 7110 10.1058 D 2890 D Common Shares 2015-12-21 4 S 0 2890 10.645 D 0 D Common Shares 2015-12-22 4 M 0 10000 0.72 A 10000 D Common Shares 2015-12-22 4 S 0 10000 10.2473 D 0 D Stock Option 0.72 2015-12-16 4 M 0 10000 0 D 2007-12-10 2016-12-09 Commom Shares 10000 40000 D Stock Option 0.72 2015-12-21 4 M 0 10000 0 D 2007-12-10 2016-12-09 Commom Shares 10000 30000 D Stock Option 0.72 2015-12-22 4 M 0 10000 0 D 2007-12-10 2016-12-09 Commom Shares 10000 20000 D This transaction was executed in multiple trades at prices ranging from $10.23 to $10.70. The price reported reflects the weighted average sale price. The Reporting Person has provided to the Issuer and will provide to any shareholder of the Issuer, or to the SEC Staff, upon request, information regarding the number of shares sold at each price within the range. This transaction was executed in multiple trades at prices ranging from $10.76 to $11.33. The price reported reflects the weighted average sale price. The Reporting Person has provided to the Issuer and will provide to any shareholder of the Issuer, or to the SEC Staff, upon request, information regarding the number of shares sold at each price within the range. This transaction was executed in multiple trades at prices ranging from $9.80 to $10.36. The price reported reflects the weighted average sale price. The Reporting Person has provided to the Issuer and will provide to any shareholder of the Issuer, or to the SEC Staff, upon request, information regarding the number of shares sold at each price within the range. This transaction was executed in multiple trades at prices ranging from $10.39 to $10.97. The price reported reflects the weighted average sale price. The Reporting Person has provided to the Issuer and will provide to any shareholder of the Issuer, or to the SEC Staff, upon request, information regarding the number of shares sold at each price within the range. This transaction was executed in multiple trades at prices ranging from $10.01 to $10.7359. The price reported reflects the weighted average sale price. The Reporting Person has provided to the Issuer and will provide to any shareholder of the Issuer, or to the SEC Staff, upon request, information regarding the number of shares sold at each price within the range. The stock option exercise price was CAD$1.00, which is equivalent of USD$0.72 Stock Options were vested 50% over 2 years with vesting date of 12/10/2006 /S/ Queena Han 2015-12-23