X0306 4 2021-11-19 0 0001626878 XBiotech Inc. XBIT 0001638762 SHIVASWAMY SUSHMA 3443 SHIRAZ LOOP ROUND ROCK TX 78665 0 1 0 0 Chief Scientific Officer Stock Option 12.67 2021-11-19 4 A 0 100000 0.00 A 2022-11-19 2031-11-19 Common Stock 100000 100000 D On November 19, 2021 (the Grant Date) the reporting person was granted stock options (the Options) under the Company's 2015 Equity Incentive Plan to purchase shares of the Company's Common Stock (the Shares) at an exercise price equal to the closing sales price of the Shares on the Grant Date as quoted by the Nasdaq Stock Market. The Options vest in two equal annual installments commencing as of the first anniversary of the Grant Date with an expiry of ten years from the Grant Date. /s/ Queena Han under Power of Attorney for Sushma Shivaswamy 2021-11-23