X0508 4 2024-01-18 0 0001626199 ALPINE IMMUNE SCIENCES, INC. ALPN 0001487815 Cui Xiangmin C/O ALPINE IMMUNE SCIENCES, INC. 201 ELLIOT AVENUE WEST, SUITE 230 SEATTLE WA 98119 1 0 1 0 0 Common Stock 2024-01-18 4 X 0 1234636 12.74 A 6582380 I See Footnote Common Stock 1735544 I See Footnote Warrant (right to buy) 12.74 2024-01-18 4 X 0 1234636 0.00 D 2019-01-18 2024-01-18 Common Stock 1234636 0 I See Footnote These securities are owned directly by Decheng Capital China Life Sciences USD Fund III, L.P. ("Fund III"). The Reporting Person is the manager of Decheng Capital Management III (Cayman), LLC, the general partner of Fund III. The Reporting Person disclaims beneficial ownership of these securities, except to the extent of his pecuniary interest therein. These securities are owned directly by Decheng Capital Global Healthcare Fund (Master), LP ("Healthcare"). The Reporting Person is the indirect managing member and ultimate beneficial owner of Decheng Capital Global Healthcare GP, LLC, the general partner of Healthcare. The Reporting Person disclaims beneficial ownership of these securities, except to the extent of his pecuniary interest therein. /s/ Xiangmin Cui 2024-01-22