X0306 4 2020-12-22 0 0001626199 ALPINE IMMUNE SCIENCES, INC. ALPN 0001413350 Venkatesan Jay C/O ALPINE IMMUNE SCIENCES, INC. 188 EAST BLAINE STREET, SUITE 200 SEATTLE WA 98102 1 0 1 0 Common Stock 2020-12-22 4 J 0 993801 0.00 D 3000980 I By Alpine ImmunoSciences, L.P. Common Stock 2020-12-22 4 J 0 181024 0.00 A 202763 D Common Stock 18633 I By Raj Venkatesan as UTMA custodian for Reid Coleman Venkatesan Common Stock 18633 I By Raj Venkatesan as UTMA custodian for Nathaniel Graham Venkatesan Alpine ImmunoSciences, L.P. distributed these shares to its limited partners on a pro rata basis for no consideration (the "Distribution"). Alpine BioVentures GP, LLC is the general partner of Alpine ImmunoSciences, L.P. Dr. Venkatesan is a Managing Partner of Alpine BioVenture GP, LLC. Dr. Venkatesan is also a limited partner of Alpine ImmunoSciences, L.P. By virtue of such relationships, Dr. Venkatesan may be deemed to have voting and investment power with respect to the shares held by Alpine ImmunoSciences, L.P. and as a result may be deemed to have beneficial ownership of such shares. The Reporting Person disclaims beneficial ownership of the shares of common stock reported herein except to the extent of his pecuniary interest therein, if any, and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of the shares for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or for any other purpose. Acquisition by the Reporting Person pursuant to the Distribution. These shares are held by Raj Venkatesan as custodian for Reporting Person's sons under the California Uniform Transfers to Minors Act. /s/ James Paul Rickey, attorney-in-fact 2020-12-22