X0306 4 2020-11-19 0 0001626199 ALPINE IMMUNE SCIENCES, INC. ALPN 0001184334 CONWAY ROBERT E C/O ALPINE IMMUNE SCIENCES, INC. 188 EAST BLAINE STREET, SUITE 200 SEATTLE WA 98102 1 0 0 0 Common Stock 2020-11-19 4 P 0 10000 8.03 A 25000 I By Robert E. Conway Rev Trust and Carolyn J. Conway Rev Trust Common Stock 0 D This transaction was executed in multiple trades at prices ranging from $7.88 to $8.0999. The price reported above reflects the weighted average purchase price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. Previously filed ownership reports reflected 15,000 shares as directly held by the reporting person. As reported in this Form 4, these 15,000 shares are also indirectly held by the Robert E. Conway Revocable Trust and Carolyn J. Conway Revocable Trust as tenants in common. /s/James Paul Rickey, attorney-in-fact 2020-11-23