X0306 4 2019-02-06 0 0001626199 ALPINE IMMUNE SCIENCES, INC. ALPN 0001242882 GOLD MITCHELL C/O ALPINE IMMUNE SCIENCES, INC. 201 ELLIOTT AVENUE WEST, SUITE 230 SEATTLE WA 98119 1 1 1 0 Executive Chairman and CEO Stock Option (right to buy) 6.51 2019-02-06 4 A 0 200000 0.00 A 2029-02-05 Common Stock 200000 200000 D The exercise price is equal to the closing price per share of Common Stock as reported on the Nasdaq Global Market on the date of grant. Twenty-five percent (25%) of the shares subject to the Option shall vest on the one (1) year anniversary of February 6, 2019 (the "Vesting Commencement Date") and one forty-eighth (1/48th) of the shares subject to the Option shall vest each month thereafter on the same day of the month as the Vesting Commencement Date (and if there is no corresponding day, on the last day of the month), subject to the Reporting Person continuing to be a Service Provider through each such date. /s/ James Paul Rickey, attorney-in-fact 2019-02-08