X0306 4 2018-08-06 0 0001626199 ALPINE IMMUNE SCIENCES, INC. ALPN 0001604834 Litton Mark James C/O ALPINE IMMUNE SCIENCES, INC. 201 ELLIOTT AVENUE WEST, SUITE 230 SEATTLE WA 98119 0 1 0 0 See Remarks Stock Option (right to buy) 6.81 2018-08-06 4 A 0 150000 0.00 A 2028-08-05 Common Stock 150000 150000 D Twenty-five percent (25%) of the shares subject to the Option shall vest on the one (1) year anniversary of August 6, 2018 (the "Vesting Commencement Date") and one forty-eighth (1/48th) of the shares subject to the Option shall vest each month thereafter on the same day of the month as the Vesting Commencement Date (and if there is no corresponding day, on the last day of the month), subject to the Reporting Person continuing to be a Service Provider through each such date. President and Chief Operating Officer /s/ J. Paul Rickey, Attorney-in-fact 2018-08-08