X0306 4 2017-07-24 0 0001626199 ALPINE IMMUNE SCIENCES, INC. ALPN 0001341382 Topper James N C/O ALPINE IMMUNE SCIENCES, INC. 201 ELLIOTT AVENUE WEST, SUITE 230 SEATTLE WA 98119 1 0 1 0 Common Stock 2017-07-24 4 A 0 2199011 A 2199011 I See Footnotes Pursuant to that certain Agreement and Plan of Merger and Reorganization (the "Merger Agreement"), dated as of April 18, 2017, by and among the Issuer, Nautilus Merger Sub, Inc. and the corporation then known as Alpine Immune Sciences, Inc. ("Old Alpine"), each share of Old Alpine common stock was converted into 0.4969 shares of the Issuer's common stock (the "Exchange Ratio"). The Reporting Person and Patrick Heron are the managing members of FHM Life Sciences VIII, L.L.C., which is the general partner of FHM Life Sciences VIII, L.P., which is the general partner of Frazier Life Sciences VIII, L.P. ("FLS VIII"), the record holder of the securities, and the Reporting Person may be deemed to share voting and dispositive power over the securities held by FLS VIII. The Reporting Person disclaims beneficial ownership over such securities except to the extent of his pecuniary interest therein, and the inclusion of these securities in this report shall not be deemed an admission of beneficial ownership of the reported securities for purposes of Section 16 or for any other purposes. /s/ James N. Topper 2017-07-26