X0206 3 2017-07-24 1 0001626199 ALPINE IMMUNE SCIENCES, INC. ALPN 0001242882 GOLD MITCHELL C/O ALPINE IMMUNE SCIENCES, INC. 201 ELLIOTT AVENUE WEST, SUITE 230 SEATTLE WA 98119 1 1 0 0 Executive Chairman and CEO Exhibit 24.1 - Power of Attorney /s/ James Paul Rickey, attorney-in-fact 2017-07-26