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                          July 14, 2020

       Paul Rickey
       Chief Financial Officer
       Alpine Immune Sciences, Inc.
       188 East Blaine Street, Suite 200
       Seattle, WA 98102

                                                        Re: Alpine Immune
Sciences, Inc.
                                                            Registration
Statement on Form S-3
                                                            Filed July 8, 2020
                                                            File No. 333-239760

       Dear Mr. Rickey:

              This is to advise you that we have not reviewed and will not
review your registration
       statement.

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Deanna
Virginio at 202-551-4530 with any questions.




                          Sincerely,


                          Division of Corporation Finance

                          Office of Life Sciences
       cc:                                              Patrick J. Schultheis,
Esq.