The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
AERIE PHARMACEUTICALS INC COM 00771V108 20,660 1,156,142 SH   DFND 2 1,156,142 0 0
ALIGN TECHNOLOGY INC COM 016255101 15,395 28,428 SH   DFND 2 28,428 0 0
ALLEGION PLC ORD SHS G0176J109 3,971 31,615 SH   DFND 2 0 0 31,615
ALPHABET INC CAP STK CL C 02079K107 901,747 435,915 SH   DFND 2 251,774 0 184,141
ALPHABET INC CAP STK CL C 02079K107 53,613 25,917 SH   DFND 1 25,917 0 0
ALPHABET INC CAP STK CL A 02079K305 1,792 869 SH   DFND 2 0 0 869
AMAZON INC COM 023135106 48,846 15,787 SH   DFND 1 15,787 0 0
AMAZON INC COM 023135106 696,010 224,949 SH   DFND 2 114,280 0 110,669
AMDOCS LTD SHS G02602103 373 5,324 SH   DFND 2 5,324 0 0
AMDOCS LTD SHS G02602103 787 11,219 SH   DFND 1 11,219 0 0
AMERICAN TOWER CORP NEW COM 03027X100 25,507 106,695 SH   DFND 1 106,695 0 0
AMERICAN TOWER CORP NEW COM 03027X100 423,768 1,772,644 SH   DFND 2 1,023,443 0 749,201
ANTHEM INC COM 036752103 43,433 121,000 SH   DFND 2 121,000 0 0
ARCO PLATFORM LTD COM CL A G04553106 195 7,695 SH   DFND 2 7,695 0 0
ARCO PLATFORM LTD COM CL A G04553106 201 7,933 SH   DFND 1 7,933 0 0
AUTOMATIC DATA PROCESSING IN COM 053015103 767 4,072 SH   DFND 2 4,072 0 0
AUTOMATIC DATA PROCESSING IN COM 053015103 1,617 8,582 SH   DFND 1 8,582 0 0
AXONICS MODULATION TECHNOLOG COM 05465P101 23,956 400,000 SH   DFND 2 400,000 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 16,916 247,498 SH   DFND 2 247,498 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 12,372 163,851 SH   DFND 2 163,851 0 0
CARA THERAPEUTICS INC COM 140755109 15,272 703,460 SH   DFND 2 703,460 0 0
CENTENE CORP DEL COM 15135B101 26,507 414,756 SH   DFND 2 414,756 0 0
COCA COLA CO COM 191216100 253 4,795 SH   DFND 2 4,795 0 0
COCA COLA CO COM 191216100 460 8,727 SH   DFND 1 8,727 0 0
COGNEX CORP COM 192422103 4,059 48,912 SH   DFND 2 0 0 48,912
COHERUS BIOSCIENCES INC COM 19249H103 15,464 1,058,464 SH   DFND 2 1,058,464 0 0
COOPER COS INC COM NEW 216648402 5,254 13,679 SH   DFND 2 0 0 13,679
CVS HEALTH CORP COM 126650100 36,085 479,656 SH   DFND 2 479,656 0 0
DEX INC COM 252131107 34,861 97,000 SH   DFND 2 97,000 0 0
DOLLAR GEN CORP NEW COM 256677105 1,554 7,669 SH   DFND 1 7,669 0 0
DOLLAR GEN CORP NEW COM 256677105 854 4,214 SH   DFND 2 4,214 0 0
DROPBOX INC CL A 26210C104 5,743 215,425 SH   DFND 2 0 0 215,425
ECOLAB INC COM 278865100 436,441 2,038,777 SH   DFND 2 1,182,099 0 856,678
ECOLAB INC COM 278865100 26,457 123,589 SH   DFND 1 123,589 0 0
EDWARDS LIFESCIENCES CORP COM 28176E108 28,547 341,311 SH   DFND 2 287,241 0 54,070
ELECTRONIC ARTS INC COM 285512109 1,127 8,328 SH   DFND 1 8,328 0 0
ELECTRONIC ARTS INC COM 285512109 4,369 32,272 SH   DFND 2 3,891 0 28,381
EXACT SCIENCES CORP COM 30063P105 33,850 256,864 SH   DFND 2 214,630 0 42,234
FIDELITY NATL INFORMATION SV COM 31620M106 624 4,440 SH   DFND 2 4,440 0 0
FIDELITY NATL INFORMATION SV COM 31620M106 1,282 9,119 SH   DFND 1 9,119 0 0
FIRST REP BK SAN FRANCISCO C COM 33616C100 448,212 2,687,929 SH   DFND 2 1,651,342 0 1,036,587
FIRST REP BK SAN FRANCISCO C COM 33616C100 25,976 155,780 SH   DFND 1 155,780 0 0
FISERV INC COM 337738108 365,793 3,072,858 SH   DFND 2 1,853,846 0 1,219,012
FISERV INC COM 337738108 24,273 203,908 SH   DFND 1 203,908 0 0
GLAUKOS CORP COM 377322102 16,552 197,212 SH   DFND 2 197,212 0 0
GLOBAL PMTS INC COM 37940X102 5,392 26,749 SH   DFND 2 0 0 26,749
GLOBANT S A COM L44385109 540 2,600 SH   DFND 2 2,600 0 0
GLOBANT S A COM L44385109 436 2,100 SH   DFND 1 2,100 0 0
HDFC BANK LTD SPONSORED ADS 40415F101 210,465 2,709,041 SH   DFND 2 1,348,977 0 1,360,064
HDFC BANK LTD SPONSORED ADS 40415F101 20,100 258,721 SH   DFND 1 258,721 0 0
HERON THERAPEUTICS INC COM 427746102 19,486 1,202,069 SH   DFND 2 1,202,069 0 0
HOME DEPOT INC COM 437076102 781,233 2,559,321 SH   DFND 2 1,467,319 0 1,092,002
HOME DEPOT INC COM 437076102 49,106 160,870 SH   DFND 1 160,870 0 0
HORIZON THERAPEUTICS PUB L SHS G46188101 39,259 426,544 SH   DFND 2 426,544 0 0
HUMANA INC COM 444859102 36,667 87,459 SH   DFND 2 87,459 0 0
ICICI BANK LIMITED ADR 45104G104 107,288 6,692,962 SH   DFND 2 2,280,588 0 4,412,374
ICICI BANK LIMITED ADR 45104G104 8,556 533,767 SH   DFND 1 533,767 0 0
IHS MARKIT LTD SHS G47567105 60,588 626,034 SH   DFND 2 579,592 0 46,442
ILLUMINA INC COM 452327109 22,267 57,978 SH   DFND 2 57,978 0 0
INFOSYS LTD SPONSORED ADR 456788108 10,332 551,903 SH   DFND 2 283,341 0 268,562
INSMED INC COM PAR $.01 457669307 11,686 343,110 SH   DFND 2 343,110 0 0
INSULET CORP COM 45784P101 19,023 72,908 SH   DFND 2 72,908 0 0
INTERCONTINENTAL EXCHANGE IN COM 45866F104 1,177 10,542 SH   DFND 1 10,542 0 0
INTERCONTINENTAL EXCHANGE IN COM 45866F104 556 4,977 SH   DFND 2 4,977 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 30,989 41,937 SH   DFND 2 41,937 0 0
IRHYTHM TECHNOLOGIES INC COM 450056106 11,109 80,000 SH   DFND 2 80,000 0 0
KARYOPHARM THERAPEUTICS INC COM 48576U106 12,624 1,200,000 SH   DFND 2 1,200,000 0 0
KEURIG DR PEPPER INC COM 49271V100 429 12,471 SH   DFND 1 12,471 0 0
KEURIG DR PEPPER INC COM 49271V100 205 5,974 SH   DFND 2 5,974 0 0
KRYSTAL BIOTECH INC COM 501147102 14,315 185,809 SH   DFND 2 185,809 0 0
LHC GROUP INC COM 50187A107 21,159 110,657 SH   DFND 2 110,657 0 0
MCCORMICK & CO INC COM NON VTG 579780206 2,641 29,626 SH   DFND 2 0 0 29,626
MCDONALDS CORP COM 580135101 920 4,104 SH   DFND 1 4,104 0 0
MCDONALDS CORP COM 580135101 435 1,941 SH   DFND 2 1,941 0 0
MERCADOLIBRE INC COM 58733R102 409 278 SH   DFND 1 278 0 0
MERCADOLIBRE INC COM 58733R102 3,739 2,540 SH   DFND 2 331 0 2,209
MICROSOFT CORP COM 594918104 801,104 3,397,822 SH   DFND 2 2,052,099 0 1,345,723
MICROSOFT CORP COM 594918104 44,325 188,000 SH   DFND 1 188,000 0 0
MONDELEZ INTL INC CL A 609207105 43,547 744,007 SH   DFND 2 744,007 0 0
MONDELEZ INTL INC CL A 609207105 445 7,602 SH   DFND 1 7,602 0 0
MSCI INC COM 55354G100 2,823 6,732 SH   DFND 2 0 0 6,732
NEW ORIENTAL ED & TECHNOLOGY SPON ADR 647581107 24,352 1,739,460 SH   DFND 2 564,710 0 1,174,750
NEW ORIENTAL ED & TECHNOLOGY SPON ADR 647581107 1,938 138,416 SH   DFND 1 138,416 0 0
NEWMONT CORP COM 651639106 1,048 17,385 SH   DFND 1 17,385 0 0
NEWMONT CORP COM 651639106 484 8,034 SH   DFND 2 8,034 0 0
NEXTERA ENERGY INC COM 65339F101 25,002 330,670 SH   DFND 1 330,670 0 0
NEXTERA ENERGY INC COM 65339F101 451,607 5,972,850 SH   DFND 2 3,255,416 0 2,717,434
NOVOCURE LTD ORD SHS G6674U108 16,758 126,784 SH   DFND 2 126,784 0 0
PAGSEGURO DIGITAL LTD COM CL A G68707101 323 6,971 SH   DFND 1 6,971 0 0
PAGSEGURO DIGITAL LTD COM CL A G68707101 340 7,345 SH   DFND 2 7,345 0 0
PROCTER AND GAMBLE CO COM 742718109 470,946 3,477,412 SH   DFND 2 2,000,523 0 1,476,889
PROCTER AND GAMBLE CO COM 742718109 29,377 216,915 SH   DFND 1 216,915 0 0
PTC INC COM 69370C100 4,449 32,323 SH   DFND 2 0 0 32,323
QUIDEL CORP COM 74838J101 20,469 160,000 SH   DFND 2 160,000 0 0
REPUBLIC SVCS INC COM 760759100 691 6,955 SH   DFND 1 6,955 0 0
REPUBLIC SVCS INC COM 760759100 326 3,286 SH   DFND 2 3,286 0 0
RESMED INC COM 761152107 3,734 19,247 SH   DFND 2 0 0 19,247
S&P GLOBAL INC COM 78409V104 361,279 1,023,830 SH   DFND 2 524,310 0 499,520
S&P GLOBAL INC COM 78409V104 26,555 75,254 SH   DFND 1 75,254 0 0
SAREPTA THERAPEUTICS INC COM 803607100 8,968 120,329 SH   DFND 2 120,329 0 0
SEA LTD SPONSORD ADS 81141R100 161,214 722,190 SH   DFND 2 235,206 0 486,984
SEA LTD SPONSORD ADS 81141R100 13,522 60,576 SH   DFND 1 60,576 0 0
SERVICE CORP INTL COM 817565104 432 8,460 SH   DFND 1 8,460 0 0
SERVICE CORP INTL COM 817565104 43,237 846,953 SH   DFND 2 746,548 0 100,405
SMITH A O CORP COM 831865209 5,149 76,158 SH   DFND 2 0 0 76,158
STONECO LTD COM CL A G85158106 264 4,311 SH   DFND 2 4,311 0 0
STONECO LTD COM CL A G85158106 291 4,753 SH   DFND 1 4,753 0 0
SYNOPSYS INC COM 871607107 4,836 19,518 SH   DFND 2 0 0 19,518
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 38,355 324,275 SH   DFND 1 324,275 0 0
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 56,653 478,976 SH   DFND 2 386,590 0 92,386
TAL EDUCATION GROUP SPONSORED ADS 874080104 2,063 38,313 SH   DFND 1 38,313 0 0
TAL EDUCATION GROUP SPONSORED ADS 874080104 23,701 440,131 SH   DFND 2 145,165 0 294,966
TELADOC HEALTH INC COM 87918A105 17,266 95,000 SH   DFND 2 95,000 0 0
TELEFLEX INCORPORATED COM 879369106 24,097 58,000 SH   DFND 2 58,000 0 0
THERAPEUTICSMD INC COM 88338N107 8,294 6,189,834 SH   DFND 2 6,189,834 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 845,849 1,853,387 SH   DFND 2 1,142,585 0 710,802
THERMO FISHER SCIENTIFIC INC COM 883556102 48,318 105,872 SH   DFND 1 105,872 0 0
TRIP COM GROUP LTD ADS 89677Q107 3,637 91,784 SH   DFND 1 91,784 0 0
TRIP COM GROUP LTD ADS 89677Q107 41,910 1,057,543 SH   DFND 2 348,687 0 708,856
TYLER TECHNOLOGIES INC COM 902252105 2,456 5,786 SH   DFND 2 0 0 5,786
VERTEX PHARMACEUTICALS INC COM 92532F100 23,328 108,557 SH   DFND 2 108,557 0 0
VISA INC COM CL A 92826C839 1,029,922 4,864,319 SH   DFND 2 2,802,483 0 2,061,836
VISA INC COM CL A 92826C839 65,202 307,947 SH   DFND 1 307,947 0 0
VOCERA MUNICATIONS INC COM 92857F107 7,310 190,058 SH   DFND 2 190,058 0 0
WASTE MGMT INC DEL COM 94106L109 1,597 12,376 SH   DFND 1 12,376 0 0
WASTE MGMT INC DEL COM 94106L109 760 5,888 SH   DFND 2 5,888 0 0
WATERS CORP COM 941848103 5,271 18,549 SH   DFND 2 0 0 18,549
WEYERHAEUSER CO MTN BE COM NEW 962166104 35,952 1,009,876 SH   DFND 2 1,009,876 0 0
WHEATON PRECIOUS METALS CORP COM 962879102 250 6,532 SH   DFND 2 6,532 0 0
WHEATON PRECIOUS METALS CORP COM 962879102 537 14,042 SH   DFND 1 14,042 0 0
WILLIS TOWERS WATSON PLC LTD SHS G96629103 558 2,440 SH   DFND 2 2,440 0 0
WILLIS TOWERS WATSON PLC LTD SHS G96629103 1,136 4,963 SH   DFND 1 4,963 0 0
XYLEM INC COM 98419M100 4,678 44,476 SH   DFND 2 0 0 44,476