The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACCELERATE DIAGNOSTICS INC COM 00430H102 3,977 524,683 SH   DFND 2 524,683 0 0
AERIE PHARMACEUTICALS INC COM 00771V108 19,672 1,456,142 SH   DFND 2 1,456,142 0 0
ALIGN TECHNOLOGY INC COM 016255101 15,191 28,428 SH   DFND 2 28,428 0 0
ALLEGION PLC ORD SHS G0176J109 3,679 31,615 SH   DFND 2 0 0 31,615
ALLSTATE CORP COM 020002101 507 4,615 SH   DFND 2 4,615 0 0
ALLSTATE CORP COM 020002101 1,515 13,778 SH   DFND 1 13,778 0 0
ALPHABET INC CAP STK CL C 02079K107 769,296 439,126 SH   DFND 2 256,721 0 182,405
ALPHABET INC CAP STK CL C 02079K107 44,023 25,129 SH   DFND 1 25,129 0 0
ALPHABET INC CAP STK CL A 02079K305 1,523 869 SH   DFND 2 0 0 869
AMAZON INC COM 023135106 727,282 223,303 SH   DFND 2 113,666 0 109,637
AMAZON INC COM 023135106 49,636 15,240 SH   DFND 1 15,240 0 0
AMDOCS LTD SHS G02602103 1,413 19,921 SH   DFND 1 19,921 0 0
AMDOCS LTD SHS G02602103 611 8,617 SH   DFND 2 8,617 0 0
AMERICAN TOWER CORP NEW COM 03027X100 401,803 1,790,088 SH   DFND 2 1,046,531 0 743,557
AMERICAN TOWER CORP NEW COM 03027X100 23,960 106,743 SH   DFND 1 106,743 0 0
ANTHEM INC COM 036752103 38,852 121,000 SH   DFND 2 121,000 0 0
ARCO PLATFORM LTD COM CL A G04553106 79 2,228 SH   DFND 1 2,228 0 0
ARCO PLATFORM LTD COM CL A G04553106 172 4,851 SH   DFND 2 4,851 0 0
ATLANTICA SUSTAINABLE INFR P SHS G0751N103 1,187 31,256 SH   DFND 1 31,256 0 0
ATLANTICA SUSTAINABLE INFR P SHS G0751N103 565 14,884 SH   DFND 2 14,884 0 0
AUTOHOME INC SP ADR RP CL A 05278C107 103 1,037 SH   DFND 1 1,037 0 0
AUTOHOME INC SP ADR RP CL A 05278C107 207 2,078 SH   DFND 2 2,078 0 0
AXONICS MODULATION TECHNOLOG COM 05465P101 19,968 400,000 SH   DFND 2 400,000 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 16,070 187,498 SH   DFND 2 187,498 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 14,368 163,851 SH   DFND 2 163,851 0 0
CARA THERAPEUTICS INC COM 140755109 10,643 703,460 SH   DFND 2 703,460 0 0
CENTENE CORP DEL COM 15135B101 24,898 414,756 SH   DFND 2 414,756 0 0
CHURCH & DWIGHT INC COM 171340102 347 3,974 SH   DFND 1 3,974 0 0
CHURCH & DWIGHT INC COM 171340102 191 2,189 SH   DFND 2 2,189 0 0
COCA COLA CO COM 191216100 381,798 6,962,040 SH   DFND 2 4,154,514 0 2,807,526
COCA COLA CO COM 191216100 23,380 426,323 SH   DFND 1 426,323 0 0
COGNEX CORP COM 192422103 3,927 48,912 SH   DFND 2 0 0 48,912
COHERUS BIOSCIENCES INC COM 19249H103 18,396 1,058,464 SH   DFND 2 1,058,464 0 0
COOPER COS INC COM NEW 216648402 4,970 13,679 SH   DFND 2 0 0 13,679
CVS HEALTH CORP COM 126650100 36,033 527,570 SH   DFND 2 527,570 0 0
DEX INC COM 252131107 35,863 97,000 SH   DFND 2 97,000 0 0
DOLLAR GEN CORP NEW COM 256677105 886 4,214 SH   DFND 2 4,214 0 0
DOLLAR GEN CORP NEW COM 256677105 1,613 7,669 SH   DFND 1 7,669 0 0
DROPBOX INC CL A 26210C104 4,780 215,425 SH   DFND 2 0 0 215,425
ECOLAB INC COM 278865100 443,907 2,051,707 SH   DFND 2 1,204,494 0 847,213
ECOLAB INC COM 278865100 25,919 119,798 SH   DFND 1 119,798 0 0
EDWARDS LIFESCIENCES CORP COM 28176E108 31,138 341,311 SH   DFND 2 287,241 0 54,070
ELECTRONIC ARTS INC COM 285512109 4,076 28,381 SH   DFND 2 0 0 28,381
EXACT SCIENCES CORP COM 30063P105 38,007 286,864 SH   DFND 2 244,630 0 42,234
FIDELITY NATL INFORMATION SV COM 31620M106 628 4,440 SH   DFND 2 4,440 0 0
FIDELITY NATL INFORMATION SV COM 31620M106 1,290 9,119 SH   DFND 1 9,119 0 0
FIRST REP BK SAN FRANCISCO C COM 33616C100 401,872 2,735,124 SH   DFND 2 1,708,976 0 1,026,148
FIRST REP BK SAN FRANCISCO C COM 33616C100 21,994 149,689 SH   DFND 1 149,689 0 0
FISERV INC COM 337738108 1,725 15,148 SH   DFND 1 15,148 0 0
FISERV INC COM 337738108 786 6,900 SH   DFND 2 6,900 0 0
GLAUKOS CORP COM 377322102 18,605 247,212 SH   DFND 2 247,212 0 0
GLOBAL PMTS INC COM 37940X102 5,762 26,749 SH   DFND 2 0 0 26,749
GLOBANT S A COM L44385109 457 2,100 SH   DFND 2 2,100 0 0
GLOBANT S A COM L44385109 261 1,200 SH   DFND 1 1,200 0 0
GW PHARMACEUTICALS PLC ADS 36197T103 10,788 93,473 SH   DFND 2 93,473 0 0
HDFC BANK LTD SPONSORED ADS 40415F101 201,644 2,790,539 SH   DFND 2 1,412,881 0 1,377,658
HDFC BANK LTD SPONSORED ADS 40415F101 18,629 257,810 SH   DFND 1 257,810 0 0
HERON THERAPEUTICS INC COM 427746102 25,442 1,202,069 SH   DFND 2 1,202,069 0 0
HOME DEPOT INC COM 437076102 683,749 2,574,161 SH   DFND 2 1,491,326 0 1,082,835
HOME DEPOT INC COM 437076102 41,442 156,018 SH   DFND 1 156,018 0 0
HORIZON THERAPEUTICS PUB L SHS G46188101 34,128 466,544 SH   DFND 2 466,544 0 0
HUMANA INC COM 444859102 35,882 87,459 SH   DFND 2 87,459 0 0
ICICI BANK LIMITED ADR 45104G104 97,421 6,555,919 SH   DFND 2 2,137,620 0 4,418,299
ICICI BANK LIMITED ADR 45104G104 6,867 462,107 SH   DFND 1 462,107 0 0
IHS MARKIT LTD SHS G47567105 61,320 682,622 SH   DFND 2 636,180 0 46,442
ILLUMINA INC COM 452327109 21,452 57,978 SH   DFND 2 57,978 0 0
INFOSYS LTD SPONSORED ADR 456788108 8,899 525,041 SH   DFND 2 249,721 0 275,320
INSMED INC COM PAR $.01 457669307 12,754 383,110 SH   DFND 2 383,110 0 0
INSULET CORP COM 45784P101 18,637 72,908 SH   DFND 2 72,908 0 0
INTERCONTINENTAL EXCHANGE IN COM 45866F104 928 8,052 SH   DFND 2 8,052 0 0
INTERCONTINENTAL EXCHANGE IN COM 45866F104 1,878 16,286 SH   DFND 1 16,286 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 34,309 41,937 SH   DFND 2 41,937 0 0
IRHYTHM TECHNOLOGIES INC COM 450056106 18,977 80,000 SH   DFND 2 80,000 0 0
JOHNSON & JOHNSON COM 478160104 448 2,848 SH   DFND 2 2,848 0 0
JOHNSON & JOHNSON COM 478160104 905 5,753 SH   DFND 1 5,753 0 0
KARYOPHARM THERAPEUTICS INC COM 48576U106 9,288 600,000 SH   DFND 2 600,000 0 0
KEURIG DR PEPPER INC COM 49271V100 1,681 52,505 SH   DFND 1 52,505 0 0
KEURIG DR PEPPER INC COM 49271V100 720 22,503 SH   DFND 2 22,503 0 0
KRYSTAL BIOTECH INC COM 501147102 11,149 185,809 SH   DFND 2 185,809 0 0
LHC GROUP INC COM 50187A107 23,605 110,657 SH   DFND 2 110,657 0 0
MCCORMICK & CO INC COM NON VTG 579780206 2,832 29,626 SH   DFND 2 0 0 29,626
MERCADOLIBRE INC COM 58733R102 4,255 2,540 SH   DFND 2 331 0 2,209
MERCADOLIBRE INC COM 58733R102 286 171 SH   DFND 1 171 0 0
MERCK & CO. INC COM 58933Y105 15,274 186,728 SH   DFND 2 186,728 0 0
MICROSOFT CORP COM 594918104 777,308 3,494,775 SH   DFND 2 2,160,515 0 1,334,260
MICROSOFT CORP COM 594918104 40,575 182,425 SH   DFND 1 182,425 0 0
MONDELEZ INTL INC CL A 609207105 444 7,602 SH   DFND 1 7,602 0 0
MONDELEZ INTL INC CL A 609207105 47,738 816,456 SH   DFND 2 816,456 0 0
MSCI INC COM 55354G100 3,006 6,732 SH   DFND 2 0 0 6,732
NEW ORIENTAL ED & TECHNOLOGY SPON ADR 647581107 2,488 13,388 SH   DFND 1 13,388 0 0
NEW ORIENTAL ED & TECHNOLOGY SPON ADR 647581107 31,995 172,194 SH   DFND 2 54,719 0 117,475
NEWMONT CORP COM 651639106 822 13,725 SH   DFND 2 13,725 0 0
NEWMONT CORP COM 651639106 1,534 25,607 SH   DFND 1 25,607 0 0
NEXTERA ENERGY INC COM 65339F101 464,438 6,019,937 SH   DFND 2 3,325,624 0 2,694,313
NEXTERA ENERGY INC COM 65339F101 24,876 322,439 SH   DFND 1 322,439 0 0
NOVOCURE LTD ORD SHS G6674U108 27,995 161,784 SH   DFND 2 161,784 0 0
PROCTER AND GAMBLE CO COM 742718109 486,631 3,497,420 SH   DFND 2 2,033,873 0 1,463,547
PROCTER AND GAMBLE CO COM 742718109 29,850 214,533 SH   DFND 1 214,533 0 0
PTC INC COM 69370C100 3,866 32,323 SH   DFND 2 0 0 32,323
QUIDEL CORP COM 74838J101 24,253 135,000 SH   DFND 2 135,000 0 0
RESMED INC COM 761152107 4,091 19,247 SH   DFND 2 0 0 19,247
S&P GLOBAL INC COM 78409V104 334,253 1,016,801 SH   DFND 2 521,824 0 494,977
S&P GLOBAL INC COM 78409V104 24,057 73,183 SH   DFND 1 73,183 0 0
SAREPTA THERAPEUTICS INC COM 803607100 20,515 120,329 SH   DFND 2 120,329 0 0
SEA LTD SPONSORD ADS 81141R100 141,460 710,678 SH   DFND 2 223,694 0 486,984
SEA LTD SPONSORD ADS 81141R100 10,732 53,915 SH   DFND 1 53,915 0 0
SERVICE CORP INTL COM 817565104 45,227 921,114 SH   DFND 2 820,709 0 100,405
SERVICE CORP INTL COM 817565104 415 8,460 SH   DFND 1 8,460 0 0
SMITH A O CORP COM 831865209 4,175 76,158 SH   DFND 2 0 0 76,158
SYNOPSYS INC COM 871607107 5,060 19,518 SH   DFND 2 0 0 19,518
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 53,856 493,910 SH   DFND 2 395,640 0 98,270
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 34,879 319,876 SH   DFND 1 319,876 0 0
TAL EDUCATION GROUP SPONSORED ADS 874080104 30,857 431,513 SH   DFND 2 136,547 0 294,966
TAL EDUCATION GROUP SPONSORED ADS 874080104 2,413 33,741 SH   DFND 1 33,741 0 0
TELADOC HEALTH INC COM 87918A105 7,998 40,000 SH   DFND 2 40,000 0 0
TELEFLEX INCORPORATED COM 879369106 23,871 58,000 SH   DFND 2 58,000 0 0
THERAPEUTICSMD INC COM 88338N107 7,490 6,189,834 SH   DFND 2 6,189,834 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 47,301 101,553 SH   DFND 1 101,553 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 872,099 1,872,341 SH   DFND 2 1,167,116 0 705,225
TYLER TECHNOLOGIES INC COM 902252105 2,526 5,786 SH   DFND 2 0 0 5,786
VERTEX PHARMACEUTICALS INC COM 92532F100 20,930 88,557 SH   DFND 2 88,557 0 0
VISA INC COM CL A 92826C839 1,091,117 4,988,419 SH   DFND 2 2,943,609 0 2,044,810
VISA INC COM CL A 92826C839 64,789 296,206 SH   DFND 1 296,206 0 0
VOCERA MUNICATIONS INC COM 92857F107 9,554 230,058 SH   DFND 2 230,058 0 0
WATERS CORP COM 941848103 4,589 18,549 SH   DFND 2 0 0 18,549
WEYERHAEUSER CO MTN BE COM NEW 962166104 37,244 1,110,756 SH   DFND 2 1,110,756 0 0
WHEATON PRECIOUS METALS CORP COM 962879102 1,358 32,526 SH   DFND 1 32,526 0 0
WHEATON PRECIOUS METALS CORP COM 962879102 752 18,023 SH   DFND 2 18,023 0 0
WILLIS TOWERS WATSON PLC LTD SHS G96629103 629 2,985 SH   DFND 1 2,985 0 0
WILLIS TOWERS WATSON PLC LTD SHS G96629103 338 1,606 SH   DFND 2 1,606 0 0
XP INC CL A G98239109 95 2,406 SH   DFND 1 2,406 0 0
XP INC CL A G98239109 164 4,123 SH   DFND 2 4,123 0 0
XYLEM INC COM 98419M100 4,527 44,476 SH   DFND 2 0 0 44,476