The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACCELERATE DIAGNOSTICS INC COM 00430H102 7,954 524,683 SH   DFND 2 524,683 0 0
AERIE PHARMACEUTICALS INC COM 00771V108 8,209 556,142 SH   DFND 2 556,142 0 0
AGNICO EAGLE MINES LTD COM 008474108 1,040 16,232 SH   DFND 2 16,232 0 0
AGNICO EAGLE MINES LTD COM 008474108 1,784 27,843 SH   DFND 1 27,843 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 19,166 88,855 SH   DFND 1 88,855 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 228,494 1,059,314 SH   DFND 2 333,974 0 725,340
ALIGN TECHNOLOGY INC COM 016255101 7,802 28,428 SH   DFND 2 28,428 0 0
ALLSTATE CORP COM 020002101 805 8,300 SH   DFND 1 8,300 0 0
ALLSTATE CORP COM 020002101 448 4,615 SH   DFND 2 4,615 0 0
ALPHABET INC CAP STK CL C 02079K107 615,739 435,579 SH   DFND 2 256,309 0 179,270
ALPHABET INC CAP STK CL C 02079K107 33,781 23,897 SH   DFND 1 23,897 0 0
ALPHABET INC CAP STK CL A 02079K305 1,232 869 SH   DFND 2 0 0 869
AMARIN CORP PLC SPONS ADR NEW 023111206 6,306 911,329 SH   DFND 2 911,329 0 0
AMAZON INC COM 023135106 693,829 251,495 SH   DFND 2 129,979 0 121,516
AMAZON INC COM 023135106 46,323 16,791 SH   DFND 1 16,791 0 0
AMDOCS LTD SHS G02602103 1,213 19,921 SH   DFND 1 19,921 0 0
AMDOCS LTD SHS G02602103 681 11,193 SH   DFND 2 11,193 0 0
AMERICAN TOWER CORP NEW COM 03027X100 459,953 1,779,041 SH   DFND 2 1,041,885 0 737,156
AMERICAN TOWER CORP NEW COM 03027X100 25,158 97,307 SH   DFND 1 97,307 0 0
ANTHEM INC COM 036752103 621 2,363 SH   DFND 1 2,363 0 0
ANTHEM INC COM 036752103 32,170 122,328 SH   DFND 2 122,328 0 0
ARCO PLATFORM LTD COM CL A G04553106 108 2,483 SH   DFND 2 2,483 0 0
ARCO PLATFORM LTD COM CL A G04553106 75 1,729 SH   DFND 1 1,729 0 0
ATLANTICA SUSTAINABLE INFR P SHS G0751N103 1,130 38,837 SH   DFND 2 38,837 0 0
ATLANTICA SUSTAINABLE INFR P SHS G0751N103 2,277 78,259 SH   DFND 1 78,259 0 0
AUTOHOME INC SP ADR RP CL A 05278C107 110 1,459 SH   DFND 2 1,459 0 0
AUTOHOME INC SP ADR RP CL A 05278C107 78 1,037 SH   DFND 1 1,037 0 0
AXONICS MODULATION TECHNOLOG COM 05465P101 14,044 400,000 SH   DFND 2 400,000 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 14,750 201,751 SH   DFND 2 201,751 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 20,209 163,851 SH   DFND 2 163,851 0 0
CARA THERAPEUTICS INC COM 140755109 12,029 703,460 SH   DFND 2 703,460 0 0
CENTENE CORP DEL COM 15135B101 30,914 486,458 SH   DFND 2 486,458 0 0
CHURCH & DWIGHT INC COM 171340102 833 10,773 SH   DFND 1 10,773 0 0
CHURCH & DWIGHT INC COM 171340102 473 6,125 SH   DFND 2 6,125 0 0
COCA COLA CO COM 191216100 306,922 6,869,332 SH   DFND 2 4,120,691 0 2,748,641
COCA COLA CO COM 191216100 18,048 403,942 SH   DFND 1 403,942 0 0
COHERUS BIOSCIENCES INC COM 19249H103 16,225 908,464 SH   DFND 2 908,464 0 0
CVS HEALTH CORP COM 126650100 33,525 516,015 SH   DFND 2 516,015 0 0
DEX INC COM 252131107 25,135 62,000 SH   DFND 2 62,000 0 0
DOLLAR GEN CORP NEW COM 256677105 318 1,668 SH   DFND 2 1,668 0 0
DOLLAR GEN CORP NEW COM 256677105 592 3,108 SH   DFND 1 3,108 0 0
ECOLAB INC COM 278865100 410,757 2,064,626 SH   DFND 2 1,216,950 0 847,676
ECOLAB INC COM 278865100 22,751 114,357 SH   DFND 1 114,357 0 0
EDWARDS LIFESCIENCES CORP COM 28176E108 19,851 287,241 SH   DFND 2 287,241 0 0
EXACT SCIENCES CORP COM 30063P105 25,180 289,630 SH   DFND 2 289,630 0 0
FIDELITY NATL INFORMATION SV COM 31620M106 214 1,599 SH   DFND 2 1,599 0 0
FIDELITY NATL INFORMATION SV COM 31620M106 369 2,749 SH   DFND 1 2,749 0 0
FIRST REP BK SAN FRANCISCO C COM 33616C100 15,296 144,317 SH   DFND 1 144,317 0 0
FIRST REP BK SAN FRANCISCO C COM 33616C100 287,348 2,711,085 SH   DFND 2 1,700,107 0 1,010,978
FISERV INC COM 337738108 950 9,732 SH   DFND 1 9,732 0 0
FISERV INC COM 337738108 510 5,228 SH   DFND 2 5,228 0 0
FRANCO NEV CORP COM 351858105 321 2,300 SH   DFND 2 2,300 0 0
GLAUKOS CORP COM 377322102 9,498 247,212 SH   DFND 2 247,212 0 0
GW PHARMACEUTICALS PLC ADS 36197T103 11,471 93,473 SH   DFND 2 93,473 0 0
HDFC BANK LTD SPONSORED ADS 40415F101 165,208 3,634,146 SH   DFND 2 1,616,536 0 2,017,610
HDFC BANK LTD SPONSORED ADS 40415F101 12,910 283,991 SH   DFND 1 283,991 0 0
HERON THERAPEUTICS INC COM 427746102 10,327 702,069 SH   DFND 2 702,069 0 0
HOME DEPOT INC COM 437076102 638,907 2,550,425 SH   DFND 2 1,488,451 0 1,061,974
HOME DEPOT INC COM 437076102 37,025 147,800 SH   DFND 1 147,800 0 0
HUMANA INC COM 444859102 25,204 65,000 SH   DFND 2 65,000 0 0
ICICI BANK LIMITED ADR 45104G104 46,149 4,967,577 SH   DFND 2 1,676,609 0 3,290,968
ICICI BANK LIMITED ADR 45104G104 3,747 403,329 SH   DFND 1 403,329 0 0
IHS MARKIT LTD SHS G47567105 48,032 636,180 SH   DFND 2 636,180 0 0
ILLUMINA INC COM 452327109 21,472 57,978 SH   DFND 2 57,978 0 0
IMMUNOMEDICS INC COM 452907108 17,011 480,000 SH   DFND 2 480,000 0 0
INFOSYS LTD SPONSORED ADR 456788108 1,308 135,365 SH   DFND 2 135,365 0 0
INSMED INC COM PAR $.01 457669307 12,203 443,110 SH   DFND 2 443,110 0 0
INSULET CORP COM 45784P101 14,163 72,908 SH   DFND 2 72,908 0 0
INTERCONTINENTAL EXCHANGE IN COM 45866F104 1,875 20,465 SH   DFND 1 20,465 0 0
INTERCONTINENTAL EXCHANGE IN COM 45866F104 1,068 11,656 SH   DFND 2 11,656 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 23,897 41,937 SH   DFND 2 41,937 0 0
JOHNSON & JOHNSON COM 478160104 372 2,647 SH   DFND 1 2,647 0 0
JOHNSON & JOHNSON COM 478160104 216 1,535 SH   DFND 2 1,535 0 0
KEURIG DR PEPPER INC COM 49271V100 779 27,447 SH   DFND 1 27,447 0 0
KEURIG DR PEPPER INC COM 49271V100 424 14,935 SH   DFND 2 14,935 0 0
KRYSTAL BIOTECH INC COM 501147102 5,625 135,809 SH   DFND 2 135,809 0 0
LHC GROUP INC COM 50187A107 23,648 135,657 SH   DFND 2 135,657 0 0
MERCADOLIBRE INC COM 58733R102 165 167 SH   DFND 1 167 0 0
MERCADOLIBRE INC COM 58733R102 296 300 SH   DFND 2 300 0 0
MERCK & CO. INC COM 58933Y105 14,440 186,728 SH   DFND 2 186,728 0 0
MICROSOFT CORP COM 594918104 706,422 3,471,190 SH   DFND 2 2,161,897 0 1,309,293
MICROSOFT CORP COM 594918104 34,965 171,812 SH   DFND 1 171,812 0 0
MONDELEZ INTL INC CL A 609207105 33,444 654,093 SH   DFND 2 654,093 0 0
MONDELEZ INTL INC CL A 609207105 1,005 19,656 SH   DFND 1 19,656 0 0
MSCI INC COM 55354G100 219,632 657,935 SH   DFND 2 348,331 0 309,604
MSCI INC COM 55354G100 15,086 45,193 SH   DFND 1 45,193 0 0
MYOKARDIA INC COM 62857M105 11,300 116,950 SH   DFND 2 116,950 0 0
NEW ORIENTAL ED & TECHNOLOGY SPON ADR 647581107 1,911 14,677 SH   DFND 1 14,677 0 0
NEW ORIENTAL ED & TECHNOLOGY SPON ADR 647581107 22,059 169,384 SH   DFND 2 51,909 0 117,475
NEWMONT CORP COM 651639106 847 13,725 SH   DFND 2 13,725 0 0
NEWMONT CORP COM 651639106 1,581 25,607 SH   DFND 1 25,607 0 0
NEXTERA ENERGY INC COM 65339F101 360,646 1,501,629 SH   DFND 2 836,149 0 665,480
NEXTERA ENERGY INC COM 65339F101 18,108 75,396 SH   DFND 1 75,396 0 0
NOVOCURE LTD ORD SHS G6674U108 20,268 341,784 SH   DFND 2 341,784 0 0
PROCTER AND GAMBLE CO COM 742718109 413,740 3,460,233 SH   DFND 2 2,025,024 0 1,435,209
PROCTER AND GAMBLE CO COM 742718109 24,583 205,599 SH   DFND 1 205,599 0 0
PROGRESSIVE CORP OHIO COM 743315103 1,295 16,170 SH   DFND 1 16,170 0 0
PROGRESSIVE CORP OHIO COM 743315103 721 8,995 SH   DFND 2 8,995 0 0
SAREPTA THERAPEUTICS INC COM 803607100 23,302 145,329 SH   DFND 2 145,329 0 0
SEA LTD SPONSORED ADS 81141R100 82,393 768,306 SH   DFND 2 239,315 0 528,991
SEA LTD SPONSORED ADS 81141R100 6,864 64,003 SH   DFND 1 64,003 0 0
SERVICE CORP INTL COM 817565104 790 20,315 SH   DFND 1 20,315 0 0
SERVICE CORP INTL COM 817565104 31,849 818,961 SH   DFND 2 818,961 0 0
STARBUCKS CORP COM 855244109 26,538 360,615 SH   DFND 2 360,615 0 0
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 43,431 765,037 SH   DFND 2 466,029 0 299,008
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 22,917 403,684 SH   DFND 1 403,684 0 0
TAL EDUCATION GROUP SPONSORED ADS 874080104 1,514 22,145 SH   DFND 1 22,145 0 0
TAL EDUCATION GROUP SPONSORED ADS 874080104 16,956 247,965 SH   DFND 2 80,392 0 167,573
TELEFLEX INCORPORATED COM 879369106 19,291 53,000 SH   DFND 2 53,000 0 0
THERAPEUTICSMD INC COM 88338N107 7,737 6,189,834 SH   DFND 2 6,189,834 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 673,019 1,857,423 SH   DFND 2 1,164,942 0 692,481
THERMO FISHER SCIENTIFIC INC COM 883556102 35,025 96,662 SH   DFND 1 96,662 0 0
TJX COS INC NEW COM 872540109 701 13,861 SH   DFND 1 13,861 0 0
TJX COS INC NEW COM 872540109 376 7,443 SH   DFND 2 7,443 0 0
UNITEDHEALTH GROUP INC COM 91324P102 703 2,383 SH   DFND 1 2,383 0 0
UNITEDHEALTH GROUP INC COM 91324P102 395 1,339 SH   DFND 2 1,339 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 19,903 68,557 SH   DFND 2 68,557 0 0
VISA INC COM CL A 92826C839 956,206 4,950,076 SH   DFND 2 2,935,951 0 2,014,125
VISA INC COM CL A 92826C839 54,416 281,699 SH   DFND 1 281,699 0 0
VOCERA MUNICATIONS INC COM 92857F107 5,407 255,058 SH   DFND 2 255,058 0 0
WEYERHAEUSER CO MTN BE COM NEW 962166104 24,410 1,086,829 SH   DFND 2 1,086,829 0 0
WHEATON PRECIOUS METALS CORP COM 962879102 1,579 35,848 SH   DFND 1 35,848 0 0
WHEATON PRECIOUS METALS CORP COM 962879102 1,243 28,214 SH   DFND 2 28,214 0 0
WILLIS TOWERS WATSON PLC LTD SHS G96629103 588 2,985 SH   DFND 1 2,985 0 0
WILLIS TOWERS WATSON PLC LTD SHS G96629103 316 1,606 SH   DFND 2 1,606 0 0