The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACCELERATE DIAGNOSTICS INC COM 00430H102 9,743 524,683 SH   DFND 2 524,683 0 0
AERIE PHARMACEUTICALS INC COM 00771V108 10,689 556,142 SH   DFND 2 556,142 0 0
ALGONQUIN PWR UTILS CORP COM 015857105 265 14,636 SH   DFND 2 14,636 0 0
ALGONQUIN PWR UTILS CORP COM 015857105 379 20,903 SH   DFND 1 20,903 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 12,641 75,592 SH   DFND 1 75,592 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 148,480 887,881 SH   DFND 2 271,354 0 616,527
ALIGN TECHNOLOGY INC COM 016255101 10,571 58,428 SH   DFND 2 58,428 0 0
ALLSTATE CORP COM 020002101 393 3,614 SH   DFND 2 3,614 0 0
ALLSTATE CORP COM 020002101 650 5,978 SH   DFND 1 5,978 0 0
ALPHABET INC CAP STK CL C 02079K107 564,298 462,919 SH   DFND 2 275,155 0 187,764
ALPHABET INC CAP STK CL C 02079K107 27,718 22,738 SH   DFND 1 22,738 0 0
ALPHABET INC CAP STK CL A 02079K305 1,061 869 SH   DFND 2 0 0 869
AMARIN CORP PLC SPONS ADR NEW 023111206 11,542 761,329 SH   DFND 2 761,329 0 0
AMAZON INC COM 023135106 470,812 271,219 SH   DFND 2 142,493 0 128,726
AMAZON INC COM 023135106 27,717 15,967 SH   DFND 1 15,967 0 0
AMDOCS LTD SHS G02602103 942 14,255 SH   DFND 1 14,255 0 0
AMDOCS LTD SHS G02602103 696 10,526 SH   DFND 2 10,526 0 0
AMERICAN TOWER CORP NEW COM 03027X100 418,528 1,892,677 SH   DFND 2 1,113,654 0 779,023
AMERICAN TOWER CORP NEW COM 03027X100 20,462 92,536 SH   DFND 1 92,536 0 0
ANNALY CAP MGMT INC COM 035710409 473 53,695 SH   DFND 1 53,695 0 0
ANNALY CAP MGMT INC COM 035710409 318 36,138 SH   DFND 2 36,138 0 0
ANTHEM INC COM 036752103 842 3,505 SH   DFND 1 3,505 0 0
ANTHEM INC COM 036752103 28,230 117,575 SH   DFND 2 117,575 0 0
AT&T INC COM 00206R102 610 16,124 SH   DFND 1 16,124 0 0
AT&T INC COM 00206R102 423 11,176 SH   DFND 2 11,176 0 0
ATLANTICA YIELD PLC SHS G0751N103 850 35,281 SH   DFND 2 35,281 0 0
ATLANTICA YIELD PLC SHS G0751N103 1,239 51,426 SH   DFND 1 51,426 0 0
AUTOHOME INC SP ADR RP CL A 05278C107 142 1,713 SH   DFND 1 1,713 0 0
AUTOHOME INC SP ADR RP CL A 05278C107 184 2,212 SH   DFND 2 2,212 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 13,006 311,751 SH   DFND 2 311,751 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 11,044 163,851 SH   DFND 2 163,851 0 0
CARA THERAPEUTICS INC COM 140755109 12,859 703,460 SH   DFND 2 703,460 0 0
CENTENE CORP DEL COM 15135B101 13,727 317,306 SH   DFND 2 317,306 0 0
COCA COLA CO COM 191216100 394,821 7,252,398 SH   DFND 2 4,359,610 0 2,892,788
COCA COLA CO COM 191216100 21,059 386,832 SH   DFND 1 386,832 0 0
COHERUS BIOSCIENCES INC COM 19249H103 16,379 808,464 SH   DFND 2 808,464 0 0
CROWN CASTLE INTL CORP NEW COM 22822V101 264 1,899 SH   DFND 1 1,899 0 0
CROWN CASTLE INTL CORP NEW COM 22822V101 182 1,312 SH   DFND 2 1,312 0 0
CVS HEALTH CORP COM 126650100 32,545 516,015 SH   DFND 2 516,015 0 0
DEX INC COM 252131107 16,452 110,240 SH   DFND 2 110,240 0 0
DYNAVAX TECHNOLOGIES CORP COM NEW 268158201 3,562 996,412 SH   DFND 2 996,412 0 0
ECOLAB INC COM 278865100 556,135 2,808,193 SH   DFND 2 1,644,117 0 1,164,076
ECOLAB INC COM 278865100 28,147 142,128 SH   DFND 1 142,128 0 0
EDWARDS LIFESCIENCES CORP COM 28176E108 21,056 95,747 SH   DFND 2 95,747 0 0
EXACT SCIENCES CORP COM 30063P105 16,170 178,932 SH   DFND 2 178,932 0 0
EXXON MOBIL CORP COM 30231G102 239,644 3,393,908 SH   DFND 2 2,076,160 0 1,317,748
EXXON MOBIL CORP COM 30231G102 13,194 186,861 SH   DFND 1 186,861 0 0
FIDELITY NATL INFORMATION SV COM 31620M106 885 6,665 SH   DFND 1 6,665 0 0
FIDELITY NATL INFORMATION SV COM 31620M106 535 4,031 SH   DFND 2 4,031 0 0
FIRST REP BK SAN FRANCISCO C COM 33616C100 277,754 2,872,331 SH   DFND 2 1,803,539 0 1,068,792
FIRST REP BK SAN FRANCISCO C COM 33616C100 13,401 138,581 SH   DFND 1 138,581 0 0
FISERV INC COM 337738108 539 5,207 SH   DFND 2 5,207 0 0
FISERV INC COM 337738108 479 4,628 SH   DFND 1 4,628 0 0
FRANCO NEVADA CORP COM 351858105 1,341 14,712 SH   DFND 1 14,712 0 0
FRANCO NEVADA CORP COM 351858105 1,606 17,619 SH   DFND 2 17,619 0 0
GLAUKOS CORP COM 377322102 10,452 167,212 SH   DFND 2 167,212 0 0
GW PHARMACEUTICALS PLC ADS 36197T103 2,700 23,473 SH   DFND 2 23,473 0 0
HDFC BANK LTD SPONSORED ADS 40415F101 11,443 200,580 SH   DFND 1 200,580 0 0
HDFC BANK LTD SPONSORED ADS 40415F101 171,611 3,008,082 SH   DFND 2 1,264,364 0 1,743,718
HERON THERAPEUTICS INC COM 427746102 12,988 702,069 SH   DFND 2 702,069 0 0
HOME DEPOT INC COM 437076102 631,611 2,722,225 SH   DFND 2 1,598,011 0 1,124,214
HOME DEPOT INC COM 437076102 32,761 141,200 SH   DFND 1 141,200 0 0
HUMANA INC COM 444859102 14,062 55,000 SH   DFND 2 55,000 0 0
ICICI BK LTD ADR 45104G104 59,125 4,854,291 SH   DFND 2 1,482,643 0 3,371,648
ICICI BK LTD ADR 45104G104 4,684 384,537 SH   DFND 1 384,537 0 0
ILLUMINA INC COM 452327109 17,638 57,978 SH   DFND 2 57,978 0 0
IMMUNOMEDICS INC COM 452907108 5,834 440,000 SH   DFND 2 440,000 0 0
INSMED INC COM PAR $.01 457669307 7,816 443,110 SH   DFND 2 443,110 0 0
INSULET CORP COM 45784P101 16,439 99,672 SH   DFND 2 99,672 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 22,643 41,937 SH   DFND 2 41,937 0 0
JOHNSON & JOHNSON COM 478160104 858 6,629 SH   DFND 1 6,629 0 0
JOHNSON & JOHNSON COM 478160104 595 4,595 SH   DFND 2 4,595 0 0
LHC GROUP INC COM 50187A107 12,566 110,657 SH   DFND 2 110,657 0 0
MERCADOLIBRE INC COM 58733R102 245 444 SH   DFND 2 444 0 0
MERCADOLIBRE INC COM 58733R102 189 343 SH   DFND 1 343 0 0
MERCK & CO INC COM 58933Y105 22,304 264,955 SH   DFND 2 264,955 0 0
MICROSOFT CORP COM 594918104 519,930 3,739,695 SH   DFND 2 2,346,459 0 1,393,236
MICROSOFT CORP COM 594918104 22,998 165,414 SH   DFND 1 165,414 0 0
MONDELEZ INTL INC CL A 609207105 35,426 640,378 SH   DFND 2 640,378 0 0
MONDELEZ INTL INC CL A 609207105 285 5,148 SH   DFND 1 5,148 0 0
MSCI INC COM 55354G100 153,222 703,661 SH   DFND 2 377,496 0 326,165
MSCI INC COM 55354G100 9,237 42,420 SH   DFND 1 42,420 0 0
NOVOCURE LTD ORD SHS G6674U108 12,472 166,784 SH   DFND 2 166,784 0 0
PAGSEGURO DIGITAL LTD COM CL A G68707101 243 5,245 SH   DFND 2 5,245 0 0
PAGSEGURO DIGITAL LTD COM CL A G68707101 192 4,146 SH   DFND 1 4,146 0 0
PFIZER INC COM 717081103 176 4,908 SH   DFND 2 4,908 0 0
PFIZER INC COM 717081103 292 8,125 SH   DFND 1 8,125 0 0
PORTOLA PHARMACEUTICALS INC COM 737010108 8,968 334,366 SH   DFND 2 334,366 0 0
PROCTER & GAMBLE CO COM 742718109 456,015 3,666,302 SH   DFND 2 2,162,381 0 1,503,921
PROCTER & GAMBLE CO COM 742718109 22,820 183,469 SH   DFND 1 183,469 0 0
PROGRESSIVE CORP OHIO COM 743315103 667 8,630 SH   DFND 2 8,630 0 0
PROGRESSIVE CORP OHIO COM 743315103 1,102 14,268 SH   DFND 1 14,268 0 0
SAREPTA THERAPEUTICS INC COM 803607100 10,946 145,329 SH   DFND 2 145,329 0 0
STARBUCKS CORP COM 855244109 31,886 360,615 SH   DFND 2 360,615 0 0
STEMLINE THERAPEUTICS INC COM 85858C107 10,396 998,677 SH   DFND 2 998,677 0 0
STORE CAP CORP COM 862121100 897 23,979 SH   DFND 1 23,979 0 0
STORE CAP CORP COM 862121100 662 17,708 SH   DFND 2 17,708 0 0
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 5,896 126,858 SH   DFND 2 126,858 0 0
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 504 10,850 SH   DFND 1 10,850 0 0
TELADOC HEALTH INC COM 87918A105 15,903 234,834 SH   DFND 2 234,834 0 0
TELEFLEX INC COM 879369106 15,289 45,000 SH   DFND 2 45,000 0 0
THERAPEUTICSMD INC COM 88338N107 11,579 3,189,834 SH   DFND 2 3,189,834 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 572,310 1,964,879 SH   DFND 2 1,236,115 0 728,764
THERMO FISHER SCIENTIFIC INC COM 883556102 26,746 91,826 SH   DFND 1 91,826 0 0
TJX COS INC NEW COM 872540109 415 7,443 SH   DFND 2 7,443 0 0
TJX COS INC NEW COM 872540109 620 11,123 SH   DFND 1 11,123 0 0
UNITEDHEALTH GROUP INC COM 91324P102 818 3,763 SH   DFND 1 3,763 0 0
UNITEDHEALTH GROUP INC COM 91324P102 624 2,870 SH   DFND 2 2,870 0 0
US BANCORP DEL COM NEW 902973304 40,113 724,850 SH   DFND 2 724,850 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 11,615 68,557 SH   DFND 2 68,557 0 0
VISA INC COM CL A 92826C839 980,190 5,698,445 SH   DFND 2 3,377,377 0 2,321,068
VISA INC COM CL A 92826C839 50,586 294,085 SH   DFND 1 294,085 0 0
VOCERA MUNICATIONS INC COM 92857F107 6,287 255,058 SH   DFND 2 255,058 0 0
WELLS FARGO CO NEW COM 949746101 269,354 5,340,090 SH   DFND 2 3,252,105 0 2,087,985
WELLS FARGO CO NEW COM 949746101 13,245 262,581 SH   DFND 1 262,581 0 0
WEYERHAEUSER CO COM 962166104 29,814 1,076,306 SH   DFND 2 1,076,306 0 0