The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBVIE INC COM 00287Y109 10,137 125,780 SH   DFND 2 125,780 0 0
ACADIA HEALTHCARE PANY IN COM 00404A109 1,574 53,712 SH   DFND 2 53,712 0 0
ACCELERATE DIAGNOSTICS INC COM 00430H102 2,411 114,683 SH   DFND 2 114,683 0 0
ACLARIS THERAPEUTICS INC COM 00461U105 890 148,506 SH   DFND 2 148,506 0 0
AERIE PHARMACEUTICALS INC COM 00771V108 6,467 136,142 SH   DFND 2 136,142 0 0
AIMMUNE THERAPEUTICS INC COM 00900T107 4,084 182,709 SH   DFND 2 182,709 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 6,397 47,325 SH   DFND 2 47,325 0 0
ALGONQUIN PWR UTILS CORP COM 015857105 1,201 79,900 SH   DFND 1 79,900 0 0
ALGONQUIN PWR UTILS CORP COM 015857105 1,323 88,000 SH   DFND 2 88,000 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 146,128 800,919 SH   DFND 2 254,512 0 546,407
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 13,660 74,868 SH   DFND 1 74,868 0 0
ALLERGAN PLC SHS G0177J108 11,111 75,890 SH   DFND 2 75,890 0 0
ALLSTATE CORP COM 020002101 563 5,978 SH   DFND 1 5,978 0 0
ALLSTATE CORP COM 020002101 712 7,559 SH   DFND 2 7,559 0 0
ALPHABET INC CAP STK CL C 02079K107 538,252 458,747 SH   DFND 2 294,395 0 164,352
ALPHABET INC CAP STK CL C 02079K107 24,519 20,897 SH   DFND 1 20,897 0 0
ALPHABET INC CAP STK CL A 02079K305 1,023 869 SH   DFND 2 0 0 869
AMARIN CORP PLC SPONS ADR NEW 023111206 15,805 761,329 SH   DFND 2 761,329 0 0
AMAZON INC COM 023135106 511,155 287,045 SH   DFND 2 166,871 0 120,174
AMAZON INC COM 023135106 29,322 16,466 SH   DFND 1 16,466 0 0
AMERICAN TOWER CORP NEW COM 03027X100 19,148 97,166 SH   DFND 1 97,166 0 0
AMERICAN TOWER CORP NEW COM 03027X100 395,773 2,008,389 SH   DFND 2 1,273,922 0 734,467
AMGEN INC COM 031162100 15,348 80,787 SH   DFND 2 80,787 0 0
ANTHEM INC COM 036752103 1,006 3,505 SH   DFND 1 3,505 0 0
ANTHEM INC COM 036752103 1,317 4,590 SH   DFND 2 4,590 0 0
ARAMARK COM 03852U106 1,074 36,333 SH   DFND 2 36,333 0 0
ARAMARK COM 03852U106 848 28,682 SH   DFND 1 28,682 0 0
AT&T INC COM 00206R102 1,068 34,066 SH   DFND 1 34,066 0 0
AT&T INC COM 00206R102 1,353 43,153 SH   DFND 2 43,153 0 0
ATLANTICA YIELD PLC SHS G0751N103 1,268 65,143 SH   DFND 2 65,143 0 0
ATLANTICA YIELD PLC SHS G0751N103 1,001 51,426 SH   DFND 1 51,426 0 0
AVERY DENNISON CORP COM 053611109 396 3,500 SH   DFND 2 3,500 0 0
BAIDU INC SPON ADR REP A 056752108 37,460 227,239 SH   DFND 2 71,240 0 155,999
BAIDU INC SPON ADR REP A 056752108 3,353 20,342 SH   DFND 1 20,342 0 0
BECTON DICKINSON & CO COM 075887109 13,224 52,955 SH   DFND 2 52,955 0 0
BIOGEN INC COM 09062X103 9,822 41,551 SH   DFND 2 41,551 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 19,649 381,751 SH   DFND 2 381,751 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 6,116 68,851 SH   DFND 2 68,851 0 0
BOSTON SCIENTIFIC CORP COM 101137107 14,093 367,194 SH   DFND 2 367,194 0 0
CARA THERAPEUTICS INC COM 140755109 2,815 143,460 SH   DFND 2 143,460 0 0
CELGENE CORP COM 151020104 9,244 97,986 SH   DFND 2 97,986 0 0
CENTENE CORP DEL COM 15135B101 9,946 187,306 SH   DFND 2 187,306 0 0
CERNER CORP COM 156782104 2,879 50,329 SH   DFND 2 50,329 0 0
CIGNA CORP NEW COM 125523100 4,827 30,018 SH   DFND 2 30,018 0 0
CLOVIS ONCOLOGY INC COM 189464100 1,577 63,530 SH   DFND 2 63,530 0 0
COCA COLA CO COM 191216100 355,261 7,581,331 SH   DFND 2 4,920,422 0 2,660,909
COCA COLA CO COM 191216100 18,600 396,924 SH   DFND 1 396,924 0 0
COHERUS BIOSCIENCES INC COM 19249H103 2,707 198,464 SH   DFND 2 198,464 0 0
COLLEGIUM PHARMACEUTICAL INC COM 19459J104 3,573 236,021 SH   DFND 2 236,021 0 0
CROWN CASTLE INTL CORP NEW COM 22822V101 1,446 11,296 SH   DFND 2 11,296 0 0
CROWN CASTLE INTL CORP NEW COM 22822V101 1,101 8,604 SH   DFND 1 8,604 0 0
CVS HEALTH CORP COM 126650100 462 8,567 SH   DFND 1 8,567 0 0
CVS HEALTH CORP COM 126650100 28,422 527,015 SH   DFND 2 527,015 0 0
DERMIRA INC COM 24983L104 4,402 324,884 SH   DFND 2 324,884 0 0
DEX INC COM 252131107 3,210 26,949 SH   DFND 2 26,949 0 0
DYNAVAX TECHNOLOGIES CORP COM NEW 268158201 3,629 496,412 SH   DFND 2 496,412 0 0
ECOLAB INC COM 278865100 567,903 3,216,849 SH   DFND 2 2,076,380 0 1,140,469
ECOLAB INC COM 278865100 26,668 151,061 SH   DFND 1 151,061 0 0
EDWARDS LIFESCIENCES CORP COM 28176E108 8,790 45,943 SH   DFND 2 45,943 0 0
EQUINIX INC COM 29444U700 747 1,649 SH   DFND 2 1,649 0 0
EQUINIX INC COM 29444U700 585 1,291 SH   DFND 1 1,291 0 0
EXACT SCIENCES CORP COM 30063P105 5,105 58,932 SH   DFND 2 58,932 0 0
EXXON MOBIL CORP COM 30231G102 325,033 4,022,687 SH   DFND 2 2,395,467 0 1,627,220
EXXON MOBIL CORP COM 30231G102 16,032 198,422 SH   DFND 1 198,422 0 0
FIDELITY NATL INFORMATION SV COM 31620M106 253 2,240 SH   DFND 1 2,240 0 0
FIDELITY NATL INFORMATION SV COM 31620M106 460 4,071 SH   DFND 2 4,071 0 0
FIRST REP BK SAN FRANCISCO C COM 33616C100 298,964 2,975,948 SH   DFND 2 1,981,993 0 993,955
FIRST REP BK SAN FRANCISCO C COM 33616C100 14,385 143,190 SH   DFND 1 143,190 0 0
FOAMIX PHARMACEUTICALS LTD SHS M46135105 1,661 442,884 SH   DFND 2 442,884 0 0
FRANCO NEVADA CORP COM 351858105 1,465 19,526 SH   DFND 2 19,526 0 0
FRANCO NEVADA CORP COM 351858105 468 6,233 SH   DFND 1 6,233 0 0
GEOPARK LTD USD SHS G38327105 105 6,082 SH   DFND 1 6,082 0 0
GEOPARK LTD USD SHS G38327105 204 11,823 SH   DFND 2 11,823 0 0
GILEAD SCIENCES INC COM 375558103 12,781 196,598 SH   DFND 2 196,598 0 0
GLAUKOS CORP COM 377322102 3,469 44,265 SH   DFND 2 44,265 0 0
GW PHARMACEUTICALS PLC ADS 36197T103 3,957 23,473 SH   DFND 2 23,473 0 0
HCA HEALTHCARE INC COM 40412C101 14,721 112,905 SH   DFND 2 112,905 0 0
HDFC BANK LTD SPONSORED ADS 40415F101 183,609 1,584,063 SH   DFND 2 929,755 0 654,308
HDFC BANK LTD SPONSORED ADS 40415F101 11,509 99,289 SH   DFND 1 99,289 0 0
HERON THERAPEUTICS INC COM 427746102 6,161 252,069 SH   DFND 2 252,069 0 0
HOLOGIC INC COM 436440101 9,647 199,328 SH   DFND 2 199,328 0 0
HOME DEPOT INC COM 437076102 548,597 2,858,913 SH   DFND 2 1,804,235 0 1,054,678
HOME DEPOT INC COM 437076102 27,870 145,242 SH   DFND 1 145,242 0 0
HORIZON PHARMA PLC SHS G4617B105 5,063 191,544 SH   DFND 2 191,544 0 0
ICICI BK LTD ADR 45104G104 56,272 4,910,304 SH   DFND 2 1,538,656 0 3,371,648
ICICI BK LTD ADR 45104G104 5,147 449,127 SH   DFND 1 449,127 0 0
ILLUMINA INC COM 452327109 4,507 14,505 SH   DFND 2 14,505 0 0
INCYTE CORP COM 45337C102 3,331 38,726 SH   DFND 2 38,726 0 0
INSMED INC COM PAR $.01 457669307 3,288 113,110 SH   DFND 2 113,110 0 0
INSULET CORP COM 45784P101 5,009 52,672 SH   DFND 2 52,672 0 0
INTERSECT ENT INC COM 46071F103 3,971 123,514 SH   DFND 2 123,514 0 0
INTRA CELLULAR THERAPIES INC COM 46116X101 1,786 146,671 SH   DFND 2 146,671 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 7,496 13,137 SH   DFND 2 13,137 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 2,156 226,681 SH   DFND 2 226,681 0 0
JAZZ PHARMACEUTICALS PLC SHS USD G50871105 4,256 29,774 SH   DFND 2 29,774 0 0
JOHNSON & JOHNSON COM 478160104 46,439 332,208 SH   DFND 2 332,208 0 0
JOHNSON & JOHNSON COM 478160104 267 1,912 SH   DFND 1 1,912 0 0
LHC GROUP INC COM 50187A107 5,062 45,657 SH   DFND 2 45,657 0 0
LILLY ELI & CO COM 532457108 11,918 91,848 SH   DFND 2 91,848 0 0
LIVANOVA PLC SHS G5509L101 8,088 83,163 SH   DFND 2 83,163 0 0
MERCK & CO INC COM 58933Y105 27,442 329,955 SH   DFND 2 329,955 0 0
MICROSOFT CORP COM 594918104 459,219 3,893,670 SH   DFND 2 2,612,241 0 1,281,429
MICROSOFT CORP COM 594918104 20,268 171,850 SH   DFND 1 171,850 0 0
MONDELEZ INTL INC CL A 609207105 32,047 641,976 SH   DFND 2 641,976 0 0
MONDELEZ INTL INC CL A 609207105 503 10,068 SH   DFND 1 10,068 0 0
MYLAN N V SHS EURO N59465109 7,297 257,473 SH   DFND 2 257,473 0 0
NEOGENOMICS INC COM NEW 64049M209 3,056 149,378 SH   DFND 2 149,378 0 0
NOVOCURE LTD ORD SHS G6674U108 5,205 108,059 SH   DFND 2 108,059 0 0
OBALON THERAPEUTICS INC COM 67424L100 395 274,399 SH   DFND 2 274,399 0 0
OPEN TEXT CORP COM 683715106 900 17,535 SH   DFND 2 17,535 0 0
OPEN TEXT CORP COM 683715106 714 13,919 SH   DFND 1 13,919 0 0
PARATEK PHARMACEUTICALS INC COM 699374302 2,520 470,150 SH   DFND 2 470,150 0 0
PFENEX INC COM 717071104 2,176 352,153 SH   DFND 2 352,153 0 0
PFIZER INC COM 717081103 345 8,125 SH   DFND 1 8,125 0 0
PFIZER INC COM 717081103 32,958 776,028 SH   DFND 2 776,028 0 0
PORTOLA PHARMACEUTICALS INC COM 737010108 5,530 159,366 SH   DFND 2 159,366 0 0
PROCTER AND GAMBLE CO COM 742718109 372,648 3,581,430 SH   DFND 2 2,320,932 0 1,260,498
PROCTER AND GAMBLE CO COM 742718109 17,398 167,212 SH   DFND 1 167,212 0 0
PROGRESSIVE CORP OHIO COM 743315103 1,029 14,268 SH   DFND 1 14,268 0 0
PROGRESSIVE CORP OHIO COM 743315103 1,305 18,106 SH   DFND 2 18,106 0 0
PUMA BIOTECHNOLOGY INC COM 74587V107 1,520 39,179 SH   DFND 2 39,179 0 0
SAREPTA THERAPEUTICS INC COM 803607100 3,019 25,329 SH   DFND 2 25,329 0 0
SPARK THERAPEUTICS INC COM 84652J103 4,258 37,392 SH   DFND 2 37,392 0 0
SPRING BK PHARMACEUTICALS IN COM 849431101 547 52,100 SH   DFND 2 52,100 0 0
STARBUCKS CORP COM 855244109 55,524 746,899 SH   DFND 2 746,899 0 0
STEMLINE THERAPEUTICS INC COM 85858C107 4,601 358,082 SH   DFND 2 358,082 0 0
STORE CAP CORP COM 862121100 803 23,979 SH   DFND 1 23,979 0 0
STORE CAP CORP COM 862121100 1,098 32,776 SH   DFND 2 32,776 0 0
SUPERNUS PHARMACEUTICALS INC COM 868459108 607 17,325 SH   DFND 2 17,325 0 0
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 313 7,630 SH   DFND 1 7,630 0 0
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 5,178 126,422 SH   DFND 2 126,422 0 0
TAKEDA PHARMACEUTICAL CO LTD SPONSORED ADS 874060205 7,463 366,380 SH   DFND 2 366,380 0 0
TELADOC HEALTH INC COM 87918A105 5,829 104,834 SH   DFND 2 104,834 0 0
THERAPEUTICSMD INC COM 88338N107 4,820 989,834 SH   DFND 2 989,834 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 580,744 2,121,671 SH   DFND 2 1,462,516 0 659,155
THERMO FISHER SCIENTIFIC INC COM 883556102 26,998 98,632 SH   DFND 1 98,632 0 0
TORONTO DOMINION BK ONT COM NEW 891160509 1,266 17,452 SH   DFND 2 17,452 0 0
TORONTO DOMINION BK ONT COM NEW 891160509 998 13,757 SH   DFND 1 13,757 0 0
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 2,647 38,168 SH   DFND 2 38,168 0 0
UNITEDHEALTH GROUP INC COM 91324P102 35,218 142,434 SH   DFND 2 142,434 0 0
UNITEDHEALTH GROUP INC COM 91324P102 788 3,186 SH   DFND 1 3,186 0 0
US BANCORP DEL COM NEW 902973304 34,931 724,850 SH   DFND 2 724,850 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 12,611 68,557 SH   DFND 2 68,557 0 0
VIKING THERAPEUTICS INC COM 92686J106 2,307 232,138 SH   DFND 2 232,138 0 0
VISA INC COM CL A 92826C839 1,129,553 7,231,917 SH   DFND 2 4,573,842 0 2,658,075
VISA INC COM CL A 92826C839 57,736 369,653 SH   DFND 1 369,653 0 0
VOCERA MUNICATIONS INC COM 92857F107 4,904 155,058 SH   DFND 2 155,058 0 0
WELLS FARGO CO NEW COM 949746101 269,477 5,576,929 SH   DFND 2 3,633,381 0 1,943,548
WELLS FARGO CO NEW COM 949746101 13,212 273,428 SH   DFND 1 273,428 0 0
WEYERHAEUSER CO COM 962166104 28,350 1,076,306 SH   DFND 2 1,076,306 0 0
WORLDPAY INC CL A 981558109 693 6,104 SH   DFND 2 6,104 0 0
WORLDPAY INC CL A 981558109 541 4,765 SH   DFND 1 4,765 0 0