The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBVIE INC COM 00287Y109 11,896 125,780 SH   DFND 2 0 0 125,780
ACADIA HEALTHCARE PANY IN COM 00404A109 2,561 72,767 SH   DFND 2 0 0 72,767
ACADIA PHARMACEUTICALS INC COM 004225108 169 8,147 SH   DFND 2 0 0 8,147
ACCELERATE DIAGNOSTICS INC COM 00430H102 3,566 155,367 SH   DFND 2 0 0 155,367
ACCELERON PHARMA INC COM 00434H108 302 5,278 SH   DFND 2 0 0 5,278
ACLARIS THERAPEUTICS INC COM 00461U105 2,988 205,751 SH   DFND 2 0 0 205,751
AERIE PHARMACEUTICALS INC COM 00771V108 6,664 108,266 SH   DFND 2 0 0 108,266
AGIOS PHARMACEUTICALS INC COM 00847X104 279 3,622 SH   DFND 2 0 0 3,622
AIMMUNE THERAPEUTICS INC COM 00900T107 5,679 208,182 SH   DFND 2 0 0 208,182
ALEXION PHARMACEUTICALS INC COM 015351109 9,153 65,847 SH   DFND 2 0 0 65,847
ALGONQUIN PWR UTILS CORP COM 015857105 1,067 79,900 SH   DFND 1 79,900 0 0
ALGONQUIN PWR UTILS CORP COM 015857105 1,176 88,000 SH   DFND 2 0 0 88,000
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 129,737 787,428 SH   DFND 2 0 0 787,428
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 12,629 76,648 SH   DFND 1 76,648 0 0
ALKERMES PLC SHS G01767105 6,853 161,466 SH   DFND 2 0 0 161,466
ALLERGAN PLC SHS G0177J108 14,456 75,890 SH   DFND 2 0 0 75,890
ALPHABET INC CAP STK CL C 02079K107 551,865 462,404 SH   DFND 2 214,982 0 247,422
ALPHABET INC CAP STK CL C 02079K107 27,768 23,267 SH   DFND 1 23,267 0 0
ALPHABET INC CAP STK CL A 02079K305 1,049 869 SH   DFND 2 0 0 869
AMARIN CORP PLC SPONS ADR NEW 023111206 11,064 680,000 SH   DFND 2 0 0 680,000
AMAZON INC COM 023135106 574,114 286,627 SH   DFND 2 103,464 0 183,163
AMAZON INC COM 023135106 36,292 18,119 SH   DFND 1 18,119 0 0
AMGEN INC COM 031162100 22,950 110,716 SH   DFND 2 0 0 110,716
ANTHEM INC COM 036752103 1,058 3,859 SH   DFND 2 0 0 3,859
ANTHEM INC COM 036752103 961 3,505 SH   DFND 1 3,505 0 0
ARAMARK COM 03852U106 969 22,526 SH   DFND 2 0 0 22,526
ARAMARK COM 03852U106 777 18,054 SH   DFND 1 18,054 0 0
AT&T INC COM 00206R102 823 24,512 SH   DFND 1 24,512 0 0
AT&T INC COM 00206R102 1,035 30,830 SH   DFND 2 0 0 30,830
ATLANTICA YIELD PLC SHS G0751N103 962 46,768 SH   DFND 2 0 0 46,768
ATLANTICA YIELD PLC SHS G0751N103 812 39,466 SH   DFND 1 39,466 0 0
AVERY DENNISON CORP COM 053611109 704 6,500 SH   DFND 2 0 0 6,500
BAIDU INC SPON ADR REP A 056752108 51,291 224,292 SH   DFND 2 0 0 224,292
BAIDU INC SPON ADR REP A 056752108 4,796 20,973 SH   DFND 1 20,973 0 0
BECTON DICKINSON & CO COM 075887109 13,821 52,955 SH   DFND 2 0 0 52,955
BIOGEN INC COM 09062X103 20,870 59,070 SH   DFND 2 0 0 59,070
BIOMARIN PHARMACEUTICAL INC COM 09061G101 7,315 75,431 SH   DFND 2 0 0 75,431
BLACK KNIGHT INC COM 09215C105 1,533 29,500 SH   DFND 2 0 0 29,500
BLUEBIRD BIO INC COM 09609G100 357 2,442 SH   DFND 2 0 0 2,442
BOSTON SCIENTIFIC CORP COM 101137107 14,137 367,194 SH   DFND 2 0 0 367,194
BRISTOL MYERS SQUIBB CO COM 110122108 7,462 120,199 SH   DFND 2 0 0 120,199
CARA THERAPEUTICS INC COM 140755109 5,926 247,429 SH   DFND 2 0 0 247,429
CELGENE CORP COM 151020104 11,347 126,797 SH   DFND 2 0 0 126,797
CENTENE CORP DEL COM 15135B101 13,559 93,653 SH   DFND 2 0 0 93,653
CIGNA CORPORATION COM 125509109 7,648 36,723 SH   DFND 2 0 0 36,723
CITIGROUP INC COM NEW 172967424 335,917 4,682,426 SH   DFND 2 2,054,139 0 2,628,287
CITIGROUP INC COM NEW 172967424 19,162 267,098 SH   DFND 1 267,098 0 0
CLOVIS ONCOLOGY INC COM 189464100 2,677 91,156 SH   DFND 2 0 0 91,156
COCA COLA CO COM 191216100 355,509 7,696,674 SH   DFND 2 3,439,758 0 4,256,916
COCA COLA CO COM 191216100 19,870 430,171 SH   DFND 1 430,171 0 0
COHERUS BIOSCIENCES INC COM 19249H103 3,760 227,896 SH   DFND 2 0 0 227,896
COLGATE PALMOLIVE CO COM 194162103 26,978 402,960 SH   DFND 2 402,960 0 0
COLLEGIUM PHARMACEUTICAL INC COM 19459J104 4,713 319,750 SH   DFND 2 0 0 319,750
CROWN CASTLE INTL CORP NEW COM 22822V101 958 8,604 SH   DFND 1 8,604 0 0
CROWN CASTLE INTL CORP NEW COM 22822V101 1,258 11,296 SH   DFND 2 0 0 11,296
CVS HEALTH CORP COM 126650100 674 8,567 SH   DFND 1 8,567 0 0
CVS HEALTH CORP COM 126650100 866 11,000 SH   DFND 2 0 0 11,000
DERMIRA INC COM 24983L104 4,445 407,771 SH   DFND 2 0 0 407,771
DEX INC COM 252131107 5,222 36,510 SH   DFND 2 0 0 36,510
DYNAVAX TECHNOLOGIES CORP COM NEW 268158201 6,767 545,715 SH   DFND 2 0 0 545,715
EAGLE PHARMACEUTICALS INC COM 269796108 1,255 18,102 SH   DFND 2 0 0 18,102
ECOLAB INC COM 278865100 508,769 3,245,112 SH   DFND 2 1,506,779 0 1,738,333
ECOLAB INC COM 278865100 26,001 165,843 SH   DFND 1 165,843 0 0
EDWARDS LIFESCIENCES CORP COM 28176E108 16,086 92,393 SH   DFND 2 0 0 92,393
ENDOLOGIX INC COM 29266S106 588 307,976 SH   DFND 2 0 0 307,976
ESPERION THERAPEUTICS INC NE COM 29664W105 222 4,999 SH   DFND 2 0 0 4,999
EXACT SCIENCES CORP COM 30063P105 7,306 92,572 SH   DFND 2 0 0 92,572
EXELIXIS INC COM 30161Q104 244 13,791 SH   DFND 2 0 0 13,791
EXPRESS SCRIPTS HLDG CO COM 30219G108 9,590 100,939 SH   DFND 2 0 0 100,939
EXXON MOBIL CORP COM 30231G102 344,853 4,056,144 SH   DFND 2 1,788,401 0 2,267,743
EXXON MOBIL CORP COM 30231G102 18,437 216,860 SH   DFND 1 216,860 0 0
FACEBOOK INC CL A 30303M102 391,943 2,383,212 SH   DFND 2 885,502 0 1,497,710
FACEBOOK INC CL A 30303M102 22,764 138,417 SH   DFND 1 138,417 0 0
FIDELITY NATL INFORMATION SV COM 31620M106 444 4,071 SH   DFND 2 0 0 4,071
FIDELITY NATL INFORMATION SV COM 31620M106 244 2,240 SH   DFND 1 2,240 0 0
FIRST REP BK SAN FRANCISCO C COM 33616C100 291,564 3,037,127 SH   DFND 2 1,491,749 0 1,545,378
FIRST REP BK SAN FRANCISCO C COM 33616C100 14,848 154,670 SH   DFND 1 154,670 0 0
FOAMIX PHARMACEUTICALS LTD SHS M46135105 3,438 600,000 SH   DFND 2 0 0 600,000
FRANCO NEVADA CORP COM 351858105 533 8,526 SH   DFND 2 0 0 8,526
FRANCO NEVADA CORP COM 351858105 390 6,233 SH   DFND 1 6,233 0 0
GEOPARK LTD USD SHS G38327105 409 20,035 SH   DFND 2 0 0 20,035
GEOPARK LTD USD SHS G38327105 223 10,927 SH   DFND 1 10,927 0 0
GILEAD SCIENCES INC COM 375558103 16,454 213,104 SH   DFND 2 0 0 213,104
GLAUKOS CORP COM 377322102 4,303 66,307 SH   DFND 2 0 0 66,307
GW PHARMACEUTICALS PLC ADS 36197T103 5,888 34,088 SH   DFND 2 0 0 34,088
HCA HEALTHCARE INC COM 40412C101 12,900 92,727 SH   DFND 2 0 0 92,727
HDFC BANK LTD ADR REPS 3 SHS 40415F101 156,130 1,659,188 SH   DFND 2 972,447 0 686,741
HDFC BANK LTD ADR REPS 3 SHS 40415F101 9,864 104,821 SH   DFND 1 104,821 0 0
HERON THERAPEUTICS INC COM 427746102 5,643 178,283 SH   DFND 2 0 0 178,283
HOLOGIC INC COM 436440101 5,435 132,631 SH   DFND 2 0 0 132,631
HOME DEPOT INC COM 437076102 598,908 2,891,179 SH   DFND 2 1,269,479 0 1,621,700
HOME DEPOT INC COM 437076102 33,206 160,297 SH   DFND 1 160,297 0 0
HORIZON PHARMA PLC SHS G4617B105 6,879 351,349 SH   DFND 2 0 0 351,349
ICICI BK LTD ADR 45104G104 40,878 4,814,856 SH   DFND 2 0 0 4,814,856
ICICI BK LTD ADR 45104G104 3,914 461,064 SH   DFND 1 461,064 0 0
INCYTE CORP COM 45337C102 3,248 47,023 SH   DFND 2 0 0 47,023
INSMED INC COM PAR $.01 457669307 4,866 240,642 SH   DFND 2 0 0 240,642
INSULET CORP COM 45784P101 3,731 35,215 SH   DFND 2 0 0 35,215
INTERCEPT PHARMACEUTICALS IN COM 45845P108 183 1,446 SH   DFND 2 0 0 1,446
INTERSECT ENT INC COM 46071F103 4,811 167,333 SH   DFND 2 0 0 167,333
INTRA CELLULAR THERAPIES INC COM 46116X101 4,312 198,703 SH   DFND 2 0 0 198,703
IONIS PHARMACEUTICALS INC COM 462222100 271 5,248 SH   DFND 2 0 0 5,248
IOVANCE BIOTHERAPEUTICS INC COM 462260100 4,507 400,603 SH   DFND 2 0 0 400,603
JAZZ PHARMACEUTICALS PLC SHS USD G50871105 8,396 49,935 SH   DFND 2 0 0 49,935
JOHNSON & JOHNSON COM 478160104 41,221 298,333 SH   DFND 2 0 0 298,333
JOHNSON & JOHNSON COM 478160104 264 1,912 SH   DFND 1 1,912 0 0
KARYOPHARM THERAPEUTICS INC COM 48576U106 311 18,249 SH   DFND 2 0 0 18,249
KRAFT HEINZ CO COM 500754106 696 12,638 SH   DFND 2 0 0 12,638
KRAFT HEINZ CO COM 500754106 493 8,945 SH   DFND 1 8,945 0 0
LEXICON PHARMACEUTICALS INC COM NEW 528872302 171 16,037 SH   DFND 2 0 0 16,037
LHC GROUP INC COM 50187A107 5,254 51,016 SH   DFND 2 0 0 51,016
LILLY ELI & CO COM 532457108 9,856 91,848 SH   DFND 2 0 0 91,848
MASTERCARD INCORPORATED CL A 57636Q104 1,046 4,700 SH   DFND 2 0 0 4,700
MCDONALDS CORP COM 580135101 704 4,207 SH   DFND 2 0 0 4,207
MCDONALDS CORP COM 580135101 550 3,288 SH   DFND 1 3,288 0 0
MERCK & CO INC COM 58933Y105 23,407 329,955 SH   DFND 2 0 0 329,955
MICROSOFT CORP COM 594918104 102,431 895,611 SH   DFND 2 892,556 0 3,055
MICROSOFT CORP COM 594918104 386 3,373 SH   DFND 1 3,373 0 0
MONDELEZ INTL INC CL A 609207105 30,848 718,071 SH   DFND 2 689,696 0 28,375
MONDELEZ INTL INC CL A 609207105 899 20,934 SH   DFND 1 20,934 0 0
MYLAN N V SHS EURO N59465109 9,424 257,473 SH   DFND 2 0 0 257,473
NEKTAR THERAPEUTICS COM 640268108 4,936 80,975 SH   DFND 2 0 0 80,975
NEOGENOMICS INC COM NEW 64049M209 3,106 202,371 SH   DFND 2 0 0 202,371
NOVOCURE LTD ORD SHS G6674U108 8,644 164,953 SH   DFND 2 0 0 164,953
NUVASIVE INC COM 670704105 3,583 50,481 SH   DFND 2 0 0 50,481
OBALON THERAPEUTICS INC COM 67424L100 852 315,504 SH   DFND 2 0 0 315,504
OPEN TEXT CORP COM 683715106 684 13,919 SH   DFND 1 13,919 0 0
OPEN TEXT CORP COM 683715106 862 17,535 SH   DFND 2 0 0 17,535
OXFORD IMMUNOTEC GLOBAL PLC ORD SHS G6855A103 2,581 158,996 SH   DFND 2 0 0 158,996
PARATEK PHARMACEUTICALS INC COM 699374302 4,930 508,282 SH   DFND 2 0 0 508,282
PFENEX INC COM 717071104 1,800 352,153 SH   DFND 2 0 0 352,153
PFIZER INC COM 717081103 28,715 651,586 SH   DFND 2 0 0 651,586
PFIZER INC COM 717081103 358 8,125 SH   DFND 1 8,125 0 0
PORTOLA PHARMACEUTICALS INC COM 737010108 5,957 223,682 SH   DFND 2 0 0 223,682
PROCTER AND GAMBLE CO COM 742718109 256,795 3,085,361 SH   DFND 2 1,138,239 0 1,947,122
PROCTER AND GAMBLE CO COM 742718109 15,058 180,922 SH   DFND 1 180,922 0 0
PROGRESSIVE CORP OHIO COM 743315103 661 9,302 SH   DFND 1 9,302 0 0
PROGRESSIVE CORP OHIO COM 743315103 824 11,602 SH   DFND 2 0 0 11,602
PUMA BIOTECHNOLOGY INC COM 74587V107 2,524 55,048 SH   DFND 2 0 0 55,048
RADIUS HEALTH INC COM NEW 750469207 131 7,336 SH   DFND 2 0 0 7,336
SAREPTA THERAPEUTICS INC COM 803607100 7,598 47,046 SH   DFND 2 0 0 47,046
SERVICE CORP INTL COM 817565104 822 18,604 SH   DFND 1 18,604 0 0
SERVICE CORP INTL COM 817565104 1,026 23,212 SH   DFND 2 0 0 23,212
SHIRE PLC SPONSORED ADR 82481R106 14,262 78,678 SH   DFND 2 0 0 78,678
SNAP ON INC COM 833034101 518 2,823 SH   DFND 2 0 0 2,823
SNAP ON INC COM 833034101 405 2,207 SH   DFND 1 2,207 0 0
SPARK THERAPEUTICS INC COM 84652J103 3,000 54,999 SH   DFND 2 0 0 54,999
SPRING BK PHARMACEUTICALS IN COM 849431101 964 79,963 SH   DFND 2 0 0 79,963
STARBUCKS CORP COM 855244109 45,956 808,522 SH   DFND 2 808,522 0 0
STEMLINE THERAPEUTICS INC COM 85858C107 2,978 179,409 SH   DFND 2 0 0 179,409
STORE CAP CORP COM 862121100 733 26,381 SH   DFND 2 0 0 26,381
STORE CAP CORP COM 862121100 666 23,979 SH   DFND 1 23,979 0 0
SUPERNUS PHARMACEUTICALS INC COM 868459108 1,182 23,473 SH   DFND 2 0 0 23,473
SYNDAX PHARMACEUTICALS INC COM 87164F105 107 13,227 SH   DFND 2 0 0 13,227
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADR 874039100 6,420 145,386 SH   DFND 2 119,686 0 25,700
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADR 874039100 556 12,583 SH   DFND 1 12,583 0 0
TESARO INC COM 881569107 3,366 86,277 SH   DFND 2 0 0 86,277
THERMO FISHER SCIENTIFIC INC COM 883556102 520,608 2,132,938 SH   DFND 2 994,640 0 1,138,298
THERMO FISHER SCIENTIFIC INC COM 883556102 26,498 108,564 SH   DFND 1 108,564 0 0
TORONTO DOMINION BK ONT COM NEW 891160509 783 9,972 SH   DFND 2 0 0 9,972
TORONTO DOMINION BK ONT COM NEW 891160509 712 9,071 SH   DFND 1 9,071 0 0
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 3,386 44,350 SH   DFND 2 0 0 44,350
UNITEDHEALTH GROUP INC COM 91324P102 41,916 157,557 SH   DFND 2 0 0 157,557
UNITEDHEALTH GROUP INC COM 91324P102 362 1,359 SH   DFND 1 1,359 0 0
VALERITAS HLDGS INC COM NEW 91914N202 360 270,807 SH   DFND 2 0 0 270,807
VERTEX PHARMACEUTICALS INC COM 92532F100 14,522 75,343 SH   DFND 2 0 0 75,343
VISA INC COM CL A 92826C839 1,116,253 7,437,222 SH   DFND 2 3,313,236 0 4,123,986
VISA INC COM CL A 92826C839 61,613 410,510 SH   DFND 1 410,510 0 0
VOCERA MUNICATIONS INC COM 92857F107 2,134 58,345 SH   DFND 2 0 0 58,345
WELLS FARGO CO NEW COM 949746101 296,120 5,633,933 SH   DFND 2 2,676,272 0 2,957,661
WELLS FARGO CO NEW COM 949746101 15,509 295,066 SH   DFND 1 295,066 0 0
WEYERHAEUSER CO COM 962166104 37,576 1,164,423 SH   DFND 2 1,164,423 0 0