The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBVIE INC COM 00287Y109 13,274 143,271 SH   DFND 2 0 0 143,271
ACADIA HEALTHCARE PANY IN COM 00404A109 3,535 86,405 SH   DFND 2 0 0 86,405
ACADIA PHARMACEUTICALS INC COM 004225108 107 7,032 SH   DFND 2 0 0 7,032
ACCELERATE DIAGNOSTICS INC COM 00430H102 4,110 184,310 SH   DFND 2 0 0 184,310
ACCELERON PHARMA INC COM 00434H108 220 4,537 SH   DFND 2 0 0 4,537
ACLARIS THERAPEUTICS INC COM 00461U105 4,838 242,251 SH   DFND 2 0 0 242,251
AERIE PHARMACEUTICALS INC COM 00771V108 7,487 110,838 SH   DFND 2 0 0 110,838
AGIOS PHARMACEUTICALS INC COM 00847X104 261 3,102 SH   DFND 2 0 0 3,102
AIMMUNE THERAPEUTICS INC COM 00900T107 6,635 246,749 SH   DFND 2 0 0 246,749
ALEXION PHARMACEUTICALS INC COM 015351109 9,383 75,574 SH   DFND 2 0 0 75,574
ALGONQUIN PWR UTILS CORP COM 015857105 1,118 88,000 SH   DFND 2 0 0 88,000
ALGONQUIN PWR UTILS CORP COM 015857105 1,015 79,900 SH   DFND 1 79,900 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 150,461 810,979 SH   DFND 2 0 0 810,979
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 14,772 79,618 SH   DFND 1 79,618 0 0
ALKERMES PLC SHS G01767105 6,646 161,466 SH   DFND 2 0 0 161,466
ALLERGAN PLC SHS G0177J108 14,188 85,101 SH   DFND 2 0 0 85,101
ALPHABET INC CAP STK CL C 02079K107 512,318 459,210 SH   DFND 2 215,208 0 244,002
ALPHABET INC CAP STK CL C 02079K107 27,886 24,995 SH   DFND 1 24,995 0 0
ALPHABET INC CAP STK CL A 02079K305 981 869 SH   DFND 2 0 0 869
AMAZON INC COM 023135106 483,491 284,440 SH   DFND 2 103,153 0 181,287
AMAZON INC COM 023135106 33,027 19,430 SH   DFND 1 19,430 0 0
AMGEN INC COM 031162100 20,437 110,716 SH   DFND 2 0 0 110,716
ANTHEM INC COM 036752103 919 3,859 SH   DFND 2 0 0 3,859
ANTHEM INC COM 036752103 834 3,505 SH   DFND 1 3,505 0 0
ARAMARK COM 03852U106 688 18,552 SH   DFND 2 0 0 18,552
ARAMARK COM 03852U106 514 13,855 SH   DFND 1 13,855 0 0
AT&T INC COM 00206R102 408 12,700 SH   DFND 2 0 0 12,700
AT&T INC COM 00206R102 228 7,101 SH   DFND 1 7,101 0 0
ATLANTICA YIELD PLC SHS G0751N103 796 39,466 SH   DFND 1 39,466 0 0
ATLANTICA YIELD PLC SHS G0751N103 877 43,436 SH   DFND 2 0 0 43,436
AVERY DENNISON CORP COM 053611109 204 2,000 SH   DFND 2 0 0 2,000
BAIDU INC SPON ADR REP A 056752108 55,863 229,890 SH   DFND 2 0 0 229,890
BAIDU INC SPON ADR REP A 056752108 5,341 21,979 SH   DFND 1 21,979 0 0
BECTON DICKINSON & CO COM 075887109 12,686 52,955 SH   DFND 2 0 0 52,955
BIOGEN INC COM 09062X103 14,102 48,586 SH   DFND 2 0 0 48,586
BIOMARIN PHARMACEUTICAL INC COM 09061G101 5,323 56,512 SH   DFND 2 0 0 56,512
BLACK KNIGHT INC COM 09215C105 2,035 38,000 SH   DFND 2 0 0 38,000
BLUEBIRD BIO INC COM 09609G100 329 2,098 SH   DFND 2 0 0 2,098
BOSTON SCIENTIFIC CORP COM 101137107 12,007 367,194 SH   DFND 2 0 0 367,194
BRISTOL MYERS SQUIBB CO COM 110122108 6,652 120,199 SH   DFND 2 0 0 120,199
CARA THERAPEUTICS INC COM 140755109 5,553 289,950 SH   DFND 2 0 0 289,950
CELGENE CORP COM 151020104 9,774 123,070 SH   DFND 2 0 0 123,070
CENTENE CORP DEL COM 15135B101 11,539 93,653 SH   DFND 2 0 0 93,653
CIGNA CORPORATION COM 125509109 6,241 36,723 SH   DFND 2 0 0 36,723
CITIGROUP INC COM NEW 172967424 26,168 391,030 SH   DFND 1 391,030 0 0
CITIGROUP INC COM NEW 172967424 416,656 6,226,175 SH   DFND 2 2,663,367 0 3,562,808
CLOVIS ONCOLOGY INC COM 189464100 4,838 106,405 SH   DFND 2 0 0 106,405
COCA COLA CO COM 191216100 315,134 7,184,993 SH   DFND 2 3,083,623 0 4,101,370
COCA COLA CO COM 191216100 19,558 445,926 SH   DFND 1 445,926 0 0
COHERUS BIOSCIENCES INC COM 19249H103 3,740 267,157 SH   DFND 2 0 0 267,157
COLGATE PALMOLIVE CO COM 194162103 26,116 402,960 SH   DFND 2 402,960 0 0
COLLEGIUM PHARMACEUTICAL INC COM 19459J104 3,536 148,244 SH   DFND 2 0 0 148,244
CROWN CASTLE INTL CORP NEW COM 22822V101 1,218 11,296 SH   DFND 2 0 0 11,296
CROWN CASTLE INTL CORP NEW COM 22822V101 928 8,604 SH   DFND 1 8,604 0 0
CVS HEALTH CORP COM 126650100 551 8,567 SH   DFND 1 8,567 0 0
CVS HEALTH CORP COM 126650100 708 11,000 SH   DFND 2 0 0 11,000
DERMIRA INC COM 24983L104 4,431 481,670 SH   DFND 2 0 0 481,670
DEX INC COM 252131107 7,656 80,603 SH   DFND 2 0 0 80,603
DYNAVAX TECHNOLOGIES CORP COM NEW 268158201 12,120 794,747 SH   DFND 2 0 0 794,747
EAGLE PHARMACEUTICALS INC COM 269796108 2,880 38,070 SH   DFND 2 0 0 38,070
ECOLAB INC COM 278865100 451,833 3,219,787 SH   DFND 2 1,507,233 0 1,712,554
ECOLAB INC COM 278865100 25,261 180,013 SH   DFND 1 180,013 0 0
EDWARDS LIFESCIENCES CORP COM 28176E108 13,450 92,393 SH   DFND 2 0 0 92,393
ENDOLOGIX INC COM 29266S106 2,063 364,464 SH   DFND 2 0 0 364,464
ESPERION THERAPEUTICS INC NE COM 29664W105 169 4,304 SH   DFND 2 0 0 4,304
EXACT SCIENCES CORP COM 30063P105 6,738 112,699 SH   DFND 2 0 0 112,699
EXELIXIS INC COM 30161Q104 254 11,818 SH   DFND 2 0 0 11,818
EXPRESS SCRIPTS HLDG CO COM 30219G108 9,235 119,604 SH   DFND 2 0 0 119,604
FACEBOOK INC CL A 30303M102 460,076 2,367,620 SH   DFND 2 890,208 0 1,477,412
FACEBOOK INC CL A 30303M102 28,872 148,580 SH   DFND 1 148,580 0 0
FIDELITY NATL INFORMATION SV COM 31620M106 432 4,071 SH   DFND 2 0 0 4,071
FIDELITY NATL INFORMATION SV COM 31620M106 238 2,240 SH   DFND 1 2,240 0 0
FIRST REP BK SAN FRANCISCO C COM 33616C100 292,650 3,023,552 SH   DFND 2 1,490,539 0 1,533,013
FIRST REP BK SAN FRANCISCO C COM 33616C100 16,230 167,686 SH   DFND 1 167,686 0 0
GEOPARK LTD USD SHS G38327105 226 10,927 SH   DFND 1 10,927 0 0
GEOPARK LTD USD SHS G38327105 414 20,035 SH   DFND 2 0 0 20,035
GILEAD SCIENCES INC COM 375558103 17,425 245,983 SH   DFND 2 0 0 245,983
GLAUKOS CORP COM 377322102 3,137 77,201 SH   DFND 2 0 0 77,201
GW PHARMACEUTICALS PLC ADS 36197T103 4,445 31,858 SH   DFND 2 0 0 31,858
HCA HEALTHCARE INC COM 40412C101 8,160 79,535 SH   DFND 2 0 0 79,535
HDFC BANK LTD ADR REPS 3 SHS 40415F101 164,080 1,562,367 SH   DFND 2 974,405 0 587,962
HDFC BANK LTD ADR REPS 3 SHS 40415F101 11,091 105,607 SH   DFND 1 105,607 0 0
HERON THERAPEUTICS INC COM 427746102 8,198 211,012 SH   DFND 2 0 0 211,012
HOLOGIC INC COM 436440101 3,533 88,877 SH   DFND 2 0 0 88,877
HOME DEPOT INC COM 437076102 560,178 2,871,237 SH   DFND 2 1,266,506 0 1,604,731
HOME DEPOT INC COM 437076102 33,523 171,825 SH   DFND 1 171,825 0 0
HORIZON PHARMA PLC SHS G4617B105 6,880 415,485 SH   DFND 2 0 0 415,485
ICICI BK LTD ADR 45104G104 39,702 4,944,191 SH   DFND 2 0 0 4,944,191
ICICI BK LTD ADR 45104G104 3,926 488,909 SH   DFND 1 488,909 0 0
INCYTE CORP COM 45337C102 3,070 45,826 SH   DFND 2 0 0 45,826
INGREDION INC COM 457187102 400 3,617 SH   DFND 1 3,617 0 0
INGREDION INC COM 457187102 513 4,637 SH   DFND 2 0 0 4,637
INSMED INC COM PAR $.01 457669307 9,719 410,954 SH   DFND 2 0 0 410,954
INSULET CORP COM 45784P101 2,528 29,495 SH   DFND 2 0 0 29,495
INTERCEPT PHARMACEUTICALS IN COM 45845P108 104 1,244 SH   DFND 2 0 0 1,244
INTERSECT ENT INC COM 46071F103 6,345 169,435 SH   DFND 2 0 0 169,435
INTRA CELLULAR THERAPIES INC COM 46116X101 3,069 173,656 SH   DFND 2 0 0 173,656
IONIS PHARMACEUTICALS INC COM 462222100 187 4,483 SH   DFND 2 0 0 4,483
IOVANCE BIOTHERAPEUTICS INC COM 462260100 4,934 385,446 SH   DFND 2 0 0 385,446
JAZZ PHARMACEUTICALS PLC SHS USD G50871105 8,545 49,592 SH   DFND 2 0 0 49,592
JOHNSON & JOHNSON COM 478160104 36,200 298,333 SH   DFND 2 0 0 298,333
JOHNSON & JOHNSON COM 478160104 232 1,912 SH   DFND 1 1,912 0 0
K2M GROUP HLDGS INC COM 48273J107 5,346 237,603 SH   DFND 2 0 0 237,603
KARYOPHARM THERAPEUTICS INC COM 48576U106 265 15,612 SH   DFND 2 0 0 15,612
KEMPHARM INC COM 488445107 2,600 399,999 SH   DFND 2 0 0 399,999
LEXICON PHARMACEUTICALS INC COM NEW 528872302 166 13,813 SH   DFND 2 0 0 13,813
LHC GROUP INC COM 50187A107 5,021 58,667 SH   DFND 2 0 0 58,667
LILLY ELI & CO COM 532457108 7,837 91,848 SH   DFND 2 0 0 91,848
MASTERCARD INCORPORATED CL A 57636Q104 1,218 6,200 SH   DFND 2 0 0 6,200
MERCK & CO INC COM 58933Y105 20,028 329,955 SH   DFND 2 0 0 329,955
MICROSOFT CORP COM 594918104 333 3,373 SH   DFND 1 3,373 0 0
MICROSOFT CORP COM 594918104 88,316 895,611 SH   DFND 2 892,556 0 3,055
MONDELEZ INTL INC CL A 609207105 29,441 718,071 SH   DFND 2 689,696 0 28,375
MONDELEZ INTL INC CL A 609207105 858 20,934 SH   DFND 1 20,934 0 0
MYLAN N V SHS EURO N59465109 11,950 330,668 SH   DFND 2 0 0 330,668
NEOGENOMICS INC COM NEW 64049M209 3,142 239,681 SH   DFND 2 0 0 239,681
NOVOCURE LTD ORD SHS G6674U108 6,672 213,153 SH   DFND 2 0 0 213,153
NUVASIVE INC COM 670704105 3,982 76,399 SH   DFND 2 0 0 76,399
OBALON THERAPEUTICS INC COM 67424L100 679 315,790 SH   DFND 2 0 0 315,790
OPEN TEXT CORP COM 683715106 998 21,574 SH   DFND 1 21,574 0 0
OPEN TEXT CORP COM 683715106 1,245 26,904 SH   DFND 2 0 0 26,904
OXFORD IMMUNOTEC GLOBAL PLC ORD SHS G6855A103 2,115 164,073 SH   DFND 2 0 0 164,073
PARATEK PHARMACEUTICALS INC COM 699374302 5,469 536,128 SH   DFND 2 0 0 536,128
PFENEX INC COM 717071104 1,964 363,068 SH   DFND 2 0 0 363,068
PFIZER INC COM 717081103 18,591 512,439 SH   DFND 2 0 0 512,439
PFIZER INC COM 717081103 295 8,125 SH   DFND 1 8,125 0 0
PHILIP MORRIS INTL INC COM 718172109 196,757 2,436,923 SH   DFND 2 759,643 0 1,677,280
PHILIP MORRIS INTL INC COM 718172109 18,878 233,807 SH   DFND 1 233,807 0 0
PORTOLA PHARMACEUTICALS INC COM 737010108 5,574 147,587 SH   DFND 2 0 0 147,587
PROCTER AND GAMBLE CO COM 742718109 110,274 1,412,687 SH   DFND 2 626,323 0 786,364
PROCTER AND GAMBLE CO COM 742718109 2,984 38,228 SH   DFND 1 38,228 0 0
PROGRESSIVE CORP OHIO COM 743315103 550 9,302 SH   DFND 1 9,302 0 0
PROGRESSIVE CORP OHIO COM 743315103 686 11,602 SH   DFND 2 0 0 11,602
PUMA BIOTECHNOLOGY INC COM 74587V107 3,820 64,585 SH   DFND 2 0 0 64,585
RADIUS HEALTH INC COM NEW 750469207 185 6,279 SH   DFND 2 0 0 6,279
SAREPTA THERAPEUTICS INC COM 803607100 9,177 69,427 SH   DFND 2 0 0 69,427
SERVICE CORP INTL COM 817565104 595 16,638 SH   DFND 2 0 0 16,638
SERVICE CORP INTL COM 817565104 477 13,340 SH   DFND 1 13,340 0 0
SHIRE PLC SPONSORED ADR 82481R106 13,281 78,678 SH   DFND 2 0 0 78,678
SNAP ON INC COM 833034101 791 4,923 SH   DFND 1 4,923 0 0
SNAP ON INC COM 833034101 987 6,140 SH   DFND 2 0 0 6,140
SPARK THERAPEUTICS INC COM 84652J103 4,270 51,596 SH   DFND 2 0 0 51,596
SPRING BK PHARMACEUTICALS IN COM 849431101 1,085 91,567 SH   DFND 2 0 0 91,567
STARBUCKS CORP COM 855244109 39,496 808,522 SH   DFND 2 808,522 0 0
STEMLINE THERAPEUTICS INC COM 85858C107 3,430 213,706 SH   DFND 2 0 0 213,706
STORE CAP CORP COM 862121100 723 26,381 SH   DFND 2 0 0 26,381
STORE CAP CORP COM 862121100 657 23,979 SH   DFND 1 23,979 0 0
SUPERNUS PHARMACEUTICALS INC COM 868459108 1,679 28,058 SH   DFND 2 0 0 28,058
SYNDAX PHARMACEUTICALS INC COM 87164F105 78 11,153 SH   DFND 2 0 0 11,153
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADR 874039100 5,628 153,945 SH   DFND 2 126,108 0 27,837
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADR 874039100 528 14,445 SH   DFND 1 14,445 0 0
TESARO INC COM 881569107 3,819 85,872 SH   DFND 2 0 0 85,872
THERMO FISHER SCIENTIFIC INC COM 883556102 439,234 2,120,470 SH   DFND 2 991,561 0 1,128,909
THERMO FISHER SCIENTIFIC INC COM 883556102 24,046 116,087 SH   DFND 1 116,087 0 0
TORONTO DOMINION BK ONT COM NEW 891160509 759 9,972 SH   DFND 2 0 0 9,972
TORONTO DOMINION BK ONT COM NEW 891160509 690 9,071 SH   DFND 1 9,071 0 0
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 4,061 52,834 SH   DFND 2 0 0 52,834
UNITEDHEALTH GROUP INC COM 91324P102 39,325 160,288 SH   DFND 2 0 0 160,288
UNITEDHEALTH GROUP INC COM 91324P102 1,059 4,316 SH   DFND 1 4,316 0 0
VALERITAS HLDGS INC COM NEW 91914N202 424 316,194 SH   DFND 2 0 0 316,194
VERTEX PHARMACEUTICALS INC COM 92532F100 10,968 64,530 SH   DFND 2 0 0 64,530
VISA INC COM CL A 92826C839 1,036,859 7,828,302 SH   DFND 2 3,505,693 0 4,322,609
VISA INC COM CL A 92826C839 62,055 468,515 SH   DFND 1 468,515 0 0
VOCERA MUNICATIONS INC COM 92857F107 2,057 68,804 SH   DFND 2 0 0 68,804
VTV THERAPEUTICS INC CL A 918385105 74 48,185 SH   DFND 2 0 0 48,185
WALGREENS BOOTS ALLIANCE INC COM 931427108 595 9,914 SH   DFND 2 0 0 9,914
WALGREENS BOOTS ALLIANCE INC COM 931427108 542 9,033 SH   DFND 1 9,033 0 0
WELLS FARGO CO NEW COM 949746101 311,171 5,612,753 SH   DFND 2 2,675,239 0 2,937,514
WELLS FARGO CO NEW COM 949746101 17,973 324,183 SH   DFND 1 324,183 0 0
WEYERHAEUSER CO COM 962166104 42,455 1,164,423 SH   DFND 2 1,164,423 0 0
ZIMMER BIOMET HLDGS INC COM 98956P102 4,550 40,830 SH   DFND 2 0 0 40,830