The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBVIE INC COM 00287Y109 12,731 143,271 SH   DFND 2 0 0 143,271
ACADIA HEALTHCARE PANY IN COM 00404A109 3,023 63,305 SH   DFND 2 0 0 63,305
ACADIA PHARMACEUTICALS INC COM 004225108 311 8,261 SH   DFND 2 0 0 8,261
ACCELERON PHARMA INC COM 00434H108 201 5,376 SH   DFND 2 0 0 5,376
ACLARIS THERAPEUTICS INC COM 00461U105 2,486 96,300 SH   DFND 2 0 0 96,300
AERIE PHARMACEUTICALS INC COM 00771V108 4,344 89,384 SH   DFND 2 0 0 89,384
AGIOS PHARMACEUTICALS INC COM 00847X104 254 3,800 SH   DFND 2 0 0 3,800
AIMMUNE THERAPEUTICS INC COM 00900T107 5,724 230,900 SH   DFND 2 0 0 230,900
ALEXION PHARMACEUTICALS INC COM 015351109 11,496 81,944 SH   DFND 2 0 0 81,944
ALGONQUIN PWR UTILS CORP COM 015857105 1,161 88,000 SH   DFND 2 0 0 88,000
ALGONQUIN PWR UTILS CORP COM 015857105 1,054 79,900 SH   DFND 1 79,900 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 142,711 826,304 SH   DFND 2 0 0 826,304
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 9,549 55,292 SH   DFND 1 55,292 0 0
ALLERGAN PLC SHS G0177J108 19,488 95,086 SH   DFND 2 0 0 95,086
ALMOST FAMILY INC COM 020409108 2,051 38,200 SH   DFND 2 0 0 38,200
ALPHABET INC CAP STK CL C 02079K107 486,730 507,481 SH   DFND 2 229,312 0 278,169
ALPHABET INC CAP STK CL C 02079K107 29,492 30,749 SH   DFND 1 30,749 0 0
ALPHABET INC CAP STK CL A 02079K305 12,677 13,019 SH   DFND 2 0 0 13,019
AMAZON INC COM 023135106 18,868 19,627 SH   DFND 1 19,627 0 0
AMAZON INC COM 023135106 272,037 282,974 SH   DFND 2 97,994 0 184,980
AMGEN INC COM 031162100 20,643 110,716 SH   DFND 2 0 0 110,716
ANTHEM INC COM 036752103 456 2,400 SH   DFND 1 2,400 0 0
ANTHEM INC COM 036752103 494 2,600 SH   DFND 2 0 0 2,600
ARAMARK COM 03852U106 296 7,300 SH   DFND 1 7,300 0 0
ARAMARK COM 03852U106 329 8,100 SH   DFND 2 0 0 8,100
AT&T INC COM 00206R102 450 11,500 SH   DFND 1 11,500 0 0
AT&T INC COM 00206R102 497 12,700 SH   DFND 2 0 0 12,700
AUTOZONE INC COM 053332102 263 442 SH   DFND 2 0 0 442
AUTOZONE INC COM 053332102 235 395 SH   DFND 1 395 0 0
AXOVANT SCIENCES LTD COM G0750W104 550 80,000 SH   DFND 2 0 0 80,000
BAIDU INC SPON ADR REP A 056752108 63,225 255,257 SH   DFND 2 0 0 255,257
BAIDU INC SPON ADR REP A 056752108 4,218 17,029 SH   DFND 1 17,029 0 0
BIOGEN INC COM 09062X103 15,551 49,665 SH   DFND 2 0 0 49,665
BIOMARIN PHARMACEUTICAL INC COM 09061G101 8,281 88,972 SH   DFND 2 0 0 88,972
BLUEBIRD BIO INC COM 09609G100 340 2,474 SH   DFND 2 0 0 2,474
BOSTON SCIENTIFIC CORP COM 101137107 10,711 367,194 SH   DFND 2 0 0 367,194
BRISTOL MYERS SQUIBB CO COM 110122108 16,383 257,031 SH   DFND 2 0 0 257,031
CARA THERAPEUTICS INC COM 140755109 3,988 291,341 SH   DFND 2 0 0 291,341
CARDINAL HEALTH INC COM 14149Y108 4,571 68,307 SH   DFND 2 0 0 68,307
CELGENE CORP COM 151020104 26,105 179,019 SH   DFND 2 0 0 179,019
CENTENE CORP DEL COM 15135B101 9,063 93,653 SH   DFND 2 0 0 93,653
CIGNA CORPORATION COM 125509109 10,988 58,777 SH   DFND 2 0 0 58,777
CITIGROUP INC COM NEW 172967424 452,509 6,220,909 SH   DFND 2 2,578,381 0 3,642,528
CITIGROUP INC COM NEW 172967424 27,813 382,358 SH   DFND 1 382,358 0 0
CLOVIS ONCOLOGY INC COM 189464100 17,356 210,627 SH   DFND 2 0 0 210,627
COCA COLA CO COM 191216100 36,310 806,708 SH   DFND 2 806,708 0 0
COHERUS BIOSCIENCES INC COM 19249H103 3,190 238,971 SH   DFND 2 0 0 238,971
COLGATE PALMOLIVE CO COM 194162103 31,273 429,285 SH   DFND 2 429,285 0 0
CREDICORP LTD COM G2519Y108 329 1,603 SH   DFND 2 0 0 1,603
CREDICORP LTD COM G2519Y108 126 613 SH   DFND 1 613 0 0
CVS HEALTH CORP COM 126650100 895 11,000 SH   DFND 2 0 0 11,000
CVS HEALTH CORP COM 126650100 933 11,470 SH   DFND 1 11,470 0 0
DERMIRA INC COM 24983L104 4,133 153,061 SH   DFND 2 0 0 153,061
DEX INC COM 252131107 2,781 56,835 SH   DFND 2 0 0 56,835
DYNAVAX TECHNOLOGIES CORP COM NEW 268158201 17,712 823,825 SH   DFND 2 0 0 823,825
EAGLE PHARMACEUTICALS INC COM 269796108 3,819 64,042 SH   DFND 2 0 0 64,042
ECOLAB INC COM 278865100 458,069 3,561,694 SH   DFND 2 1,574,859 0 1,986,835
ECOLAB INC COM 278865100 26,670 207,372 SH   DFND 1 207,372 0 0
EDWARDS LIFESCIENCES CORP COM 28176E108 10,099 92,393 SH   DFND 2 0 0 92,393
ENDOLOGIX INC COM 29266S106 2,200 493,325 SH   DFND 2 0 0 493,325
ESPERION THERAPEUTICS INC NE COM 29664W105 251 5,012 SH   DFND 2 0 0 5,012
EXACT SCIENCES CORP COM 30063P105 7,215 153,130 SH   DFND 2 0 0 153,130
EXELIXIS INC COM 30161Q104 6,896 284,588 SH   DFND 2 0 0 284,588
EXPRESS SCRIPTS HLDG CO COM 30219G108 7,235 114,268 SH   DFND 2 0 0 114,268
FACEBOOK INC CL A 30303M102 460,763 2,696,570 SH   DFND 2 941,342 0 1,755,228
FACEBOOK INC CL A 30303M102 31,203 182,614 SH   DFND 1 182,614 0 0
FIDELITY NATL INFORMATION SV COM 31620M106 380 4,071 SH   DFND 2 0 0 4,071
FIDELITY NATL INFORMATION SV COM 31620M106 370 3,959 SH   DFND 1 3,959 0 0
FIRST REP BK SAN FRANCISCO C COM 33616C100 319,009 3,053,885 SH   DFND 2 1,484,120 0 1,569,765
FIRST REP BK SAN FRANCISCO C COM 33616C100 17,449 167,036 SH   DFND 1 167,036 0 0
FLEX PHARMA INC COM 33938A105 889 260,584 SH   DFND 2 0 0 260,584
GILEAD SCIENCES INC COM 375558103 331,809 4,095,391 SH   DFND 2 1,699,482 0 2,395,909
GILEAD SCIENCES INC COM 375558103 17,147 211,644 SH   DFND 1 211,644 0 0
GLAUKOS CORP COM 377322102 9,617 291,425 SH   DFND 2 0 0 291,425
GW PHARMACEUTICALS PLC ADS 36197T103 3,234 31,863 SH   DFND 2 0 0 31,863
HCA HEALTHCARE INC COM 40412C101 10,396 130,618 SH   DFND 2 0 0 130,618
HDFC BANK LTD ADR REPS 3 SHS 40415F101 8,327 86,407 SH   DFND 1 86,407 0 0
HDFC BANK LTD ADR REPS 3 SHS 40415F101 135,391 1,404,905 SH   DFND 2 904,534 0 500,371
HERON THERAPEUTICS INC COM 427746102 1,615 100,000 SH   DFND 2 0 0 100,000
HOME DEPOT INC COM 437076102 472,274 2,887,466 SH   DFND 2 1,241,263 0 1,646,203
HOME DEPOT INC COM 437076102 28,042 171,449 SH   DFND 1 171,449 0 0
HORIZON PHARMA PLC SHS G4617B105 4,858 383,148 SH   DFND 2 0 0 383,148
ICICI BK LTD ADR 45104G104 2,657 310,429 SH   DFND 1 310,429 0 0
ICICI BK LTD ADR 45104G104 41,012 4,791,161 SH   DFND 2 0 0 4,791,161
INCYTE CORP COM 45337C102 8,865 75,941 SH   DFND 2 0 0 75,941
INGREDION INC COM 457187102 844 7,000 SH   DFND 1 7,000 0 0
INGREDION INC COM 457187102 808 6,700 SH   DFND 2 0 0 6,700
INSMED INC COM PAR $.01 457669307 13,964 447,429 SH   DFND 2 0 0 447,429
INSULET CORP COM 45784P101 5,568 101,083 SH   DFND 2 0 0 101,083
INTERCEPT PHARMACEUTICALS IN COM 45845P108 82 1,417 SH   DFND 2 0 0 1,417
INTERSECT ENT INC COM 46071F103 4,571 146,726 SH   DFND 2 0 0 146,726
INTRA CELLULAR THERAPIES INC COM 46116X101 3,821 242,156 SH   DFND 2 0 0 242,156
IONIS PHARMACEUTICALS INC COM 462222100 268 5,285 SH   DFND 2 0 0 5,285
JAZZ PHARMACEUTICALS PLC SHS USD G50871105 7,305 49,951 SH   DFND 2 0 0 49,951
JOHNSON & JOHNSON COM 478160104 699 5,379 SH   DFND 1 5,379 0 0
JOHNSON & JOHNSON COM 478160104 39,114 300,852 SH   DFND 2 0 0 300,852
JPMORGAN CHASE & CO COM 46625H100 478 5,000 SH   DFND 2 0 0 5,000
JPMORGAN CHASE & CO COM 46625H100 506 5,300 SH   DFND 1 5,300 0 0
K2M GROUP HLDGS INC COM 48273J107 4,267 201,192 SH   DFND 2 0 0 201,192
KARYOPHARM THERAPEUTICS INC COM 48576U106 203 18,515 SH   DFND 2 0 0 18,515
KEMPHARM INC COM 488445107 1,611 435,528 SH   DFND 2 0 0 435,528
LEXICON PHARMACEUTICALS INC COM NEW 528872302 198 16,146 SH   DFND 2 0 0 16,146
LILLY ELI & CO COM 532457108 10,703 125,120 SH   DFND 2 0 0 125,120
MASTERCARD INCORPORATED CL A 57636Q104 1,737 12,300 SH   DFND 2 0 0 12,300
MERCK & CO INC COM 58933Y105 12,858 200,817 SH   DFND 2 0 0 200,817
MICROSOFT CORP COM 594918104 71,099 954,481 SH   DFND 2 954,481 0 0
MONDELEZ INTL INC CL A 609207105 30,510 750,360 SH   DFND 2 734,753 0 15,607
MONDELEZ INTL INC CL A 609207105 577 14,189 SH   DFND 1 14,189 0 0
MYLAN N V SHS EURO N59465109 5,852 186,539 SH   DFND 2 0 0 186,539
NEOGENOMICS INC COM NEW 64049M209 2,719 244,300 SH   DFND 2 0 0 244,300
NOVOCURE LTD ORD SHS G6674U108 4,575 230,500 SH   DFND 2 0 0 230,500
NUVASIVE INC COM 670704105 5,259 94,827 SH   DFND 2 0 0 94,827
OBALON THERAPEUTICS INC COM 67424L100 2,632 276,211 SH   DFND 2 0 0 276,211
OPEN TEXT CORP COM 683715106 930 23,100 SH   DFND 1 23,100 0 0
OPEN TEXT CORP COM 683715106 1,031 25,600 SH   DFND 2 0 0 25,600
OXFORD IMMUNOTEC GLOBAL PLC ORD SHS G6855A103 3,078 183,235 SH   DFND 2 0 0 183,235
PARATEK PHARMACEUTICALS INC COM 699374302 16,192 645,100 SH   DFND 2 0 0 645,100
PFENEX INC COM 717071104 820 271,400 SH   DFND 2 0 0 271,400
PFIZER INC COM 717081103 18,832 527,502 SH   DFND 2 0 0 527,502
PFIZER INC COM 717081103 781 21,877 SH   DFND 1 21,877 0 0
PHILIP MORRIS INTL INC COM 718172109 287,546 2,590,269 SH   DFND 2 769,148 0 1,821,121
PHILIP MORRIS INTL INC COM 718172109 26,161 235,666 SH   DFND 1 235,666 0 0
PORTOLA PHARMACEUTICALS INC COM 737010108 6,635 122,801 SH   DFND 2 0 0 122,801
PRICELINE GRP INC COM NEW 741503403 184,219 100,621 SH   DFND 2 34,833 0 65,788
PRICELINE GRP INC COM NEW 741503403 12,426 6,787 SH   DFND 1 6,787 0 0
PROGRESSIVE CORP OHIO COM 743315103 654 13,500 SH   DFND 1 13,500 0 0
PROGRESSIVE CORP OHIO COM 743315103 721 14,900 SH   DFND 2 0 0 14,900
PUMA BIOTECHNOLOGY INC COM 74587V107 2,849 23,792 SH   DFND 2 0 0 23,792
RADIUS HEALTH INC COM NEW 750469207 283 7,353 SH   DFND 2 0 0 7,353
SAREPTA THERAPEUTICS INC COM 803607100 5,555 122,469 SH   DFND 2 0 0 122,469
SHIRE PLC SPONSORED ADR 82481R106 10,600 69,219 SH   DFND 2 0 0 69,219
SNAP ON INC COM 833034101 1,210 8,120 SH   DFND 2 0 0 8,120
SNAP ON INC COM 833034101 1,101 7,387 SH   DFND 1 7,387 0 0
SPARK THERAPEUTICS INC COM 84652J103 4,667 52,349 SH   DFND 2 0 0 52,349
SPRING BK PHARMACEUTICALS IN COM 849431101 1,873 111,200 SH   DFND 2 0 0 111,200
STARBUCKS CORP COM 855244109 46,412 864,125 SH   DFND 2 864,125 0 0
STEMLINE THERAPEUTICS INC COM 85858C107 1,776 160,000 SH   DFND 2 0 0 160,000
STORE CAP CORP COM 862121100 596 23,979 SH   DFND 1 23,979 0 0
STORE CAP CORP COM 862121100 656 26,381 SH   DFND 2 0 0 26,381
SUPERNUS PHARMACEUTICALS INC COM 868459108 2,846 71,143 SH   DFND 2 0 0 71,143
SYNDAX PHARMACEUTICALS INC COM 87164F105 156 13,300 SH   DFND 2 0 0 13,300
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADR 874039100 58,603 1,560,662 SH   DFND 2 661,157 0 899,505
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADR 874039100 21,883 582,773 SH   DFND 1 582,773 0 0
TESARO INC COM 881569107 2,700 20,916 SH   DFND 2 0 0 20,916
TEVA PHARMACEUTICAL INDS LTD SPONSORED ADR 881624209 5,742 326,269 SH   DFND 2 0 0 326,269
THERMO FISHER SCIENTIFIC INC COM 883556102 399,964 2,113,974 SH   DFND 2 985,784 0 1,128,190
THERMO FISHER SCIENTIFIC INC COM 883556102 22,660 119,766 SH   DFND 1 119,766 0 0
TJX COS INC NEW COM 872540109 597 8,100 SH   DFND 1 8,100 0 0
TJX COS INC NEW COM 872540109 664 9,000 SH   DFND 2 0 0 9,000
TORONTO DOMINION BK ONT COM NEW 891160509 1,238 17,618 SH   DFND 1 17,618 0 0
TORONTO DOMINION BK ONT COM NEW 891160509 1,385 19,714 SH   DFND 2 0 0 19,714
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 4,138 77,691 SH   DFND 2 0 0 77,691
UNITEDHEALTH GROUP INC COM 91324P102 38,007 194,063 SH   DFND 2 0 0 194,063
UNITEDHEALTH GROUP INC COM 91324P102 1,077 5,500 SH   DFND 1 5,500 0 0
VALEANT PHARMACEUTICALS INTL COM 91911K102 2,779 193,908 SH   DFND 2 0 0 193,908
VALERITAS HLDGS INC COM NEW 91914N202 800 246,978 SH   DFND 2 0 0 246,978
VERTEX PHARMACEUTICALS INC COM 92532F100 5,800 38,146 SH   DFND 2 0 0 38,146
VISA INC COM CL A 92826C839 900,581 8,557,398 SH   DFND 2 3,685,850 0 4,871,548
VISA INC COM CL A 92826C839 55,277 525,248 SH   DFND 1 525,248 0 0
WALGREENS BOOTS ALLIANCE INC COM 931427108 766 9,914 SH   DFND 2 0 0 9,914
WALGREENS BOOTS ALLIANCE INC COM 931427108 698 9,033 SH   DFND 1 9,033 0 0
WELLS FARGO CO NEW COM 949746101 311,304 5,644,670 SH   DFND 2 2,643,564 0 3,001,106
WELLS FARGO CO NEW COM 949746101 18,523 335,858 SH   DFND 1 335,858 0 0
WEYERHAEUSER CO COM 962166104 42,307 1,243,221 SH   DFND 2 1,243,221 0 0
ZIMMER BIOMET HLDGS INC COM 98956P102 6,983 59,639 SH   DFND 2 0 0 59,639