The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBVIE INC COM 00287Y109 12,403 171,047 SH   DFND 2 0 0 171,047
ACADIA HEALTHCARE PANY IN COM 00404A109 2,667 54,000 SH   DFND 2 0 0 54,000
ACADIA PHARMACEUTICALS INC COM 004225108 194 6,941 SH   DFND 2 0 0 6,941
ACCELERON PHARMA INC COM 00434H108 138 4,539 SH   DFND 2 0 0 4,539
ACLARIS THERAPEUTICS INC COM 00461U105 2,620 96,600 SH   DFND 2 0 0 96,600
AERIE PHARMACEUTICALS INC COM 00771V108 4,706 89,549 SH   DFND 2 0 0 89,549
AGIOS PHARMACEUTICALS INC COM 00847X104 82 1,600 SH   DFND 2 0 0 1,600
AIMMUNE THERAPEUTICS INC COM 00900T107 5,115 248,800 SH   DFND 2 0 0 248,800
ALEXION PHARMACEUTICALS INC COM 015351109 13,801 113,427 SH   DFND 2 0 0 113,427
ALGONQUIN PWR UTILS CORP COM 015857105 1,781 130,500 SH   DFND 2 0 0 130,500
ALGONQUIN PWR UTILS CORP COM 015857105 1,822 133,500 SH   DFND 1 133,500 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 108,279 768,481 SH   DFND 2 0 0 768,481
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 7,205 51,134 SH   DFND 1 51,134 0 0
ALLERGAN PLC SHS G0177J108 24,015 98,790 SH   DFND 2 0 0 98,790
ALMOST FAMILY INC COM 020409108 1,480 24,000 SH   DFND 2 0 0 24,000
ALPHABET INC CAP STK CL C 02079K107 448,608 493,665 SH   DFND 2 235,067 0 258,598
ALPHABET INC CAP STK CL C 02079K107 28,886 31,787 SH   DFND 1 31,787 0 0
ALPHABET INC CAP STK CL A 02079K305 12,136 13,054 SH   DFND 2 0 0 13,054
AMAZON INC COM 023135106 267,425 276,265 SH   DFND 2 101,136 0 175,129
AMAZON INC COM 023135106 19,027 19,656 SH   DFND 1 19,656 0 0
AMGEN INC COM 031162100 19,846 115,228 SH   DFND 2 0 0 115,228
ARAMARK COM 03852U106 811 19,800 SH   DFND 1 19,800 0 0
ARAMARK COM 03852U106 893 21,800 SH   DFND 2 0 0 21,800
AT&T INC COM 00206R102 479 12,700 SH   DFND 2 0 0 12,700
AT&T INC COM 00206R102 434 11,500 SH   DFND 1 11,500 0 0
AUTOZONE INC COM 053332102 252 442 SH   DFND 2 0 0 442
AUTOZONE INC COM 053332102 225 395 SH   DFND 1 395 0 0
AXOVANT SCIENCES LTD COM G0750W104 3,049 131,500 SH   DFND 2 0 0 131,500
BAIDU INC SPON ADR REP A 056752108 2,576 14,405 SH   DFND 1 14,405 0 0
BAIDU INC SPON ADR REP A 056752108 42,235 236,136 SH   DFND 2 0 0 236,136
BIOGEN INC COM 09062X103 17,740 65,375 SH   DFND 2 0 0 65,375
BIOMARIN PHARMACEUTICAL INC COM 09061G101 9,425 103,781 SH   DFND 2 0 0 103,781
BLUEBIRD BIO INC COM 09609G100 221 2,100 SH   DFND 2 0 0 2,100
BOSTON SCIENTIFIC CORP COM 101137107 10,574 381,472 SH   DFND 2 0 0 381,472
BRISTOL MYERS SQUIBB CO COM 110122108 14,878 267,012 SH   DFND 2 0 0 267,012
CARA THERAPEUTICS INC COM 140755109 2,540 165,011 SH   DFND 2 0 0 165,011
CARDINAL HEALTH INC COM 14149Y108 5,562 71,382 SH   DFND 2 0 0 71,382
CELGENE CORP COM 151020104 23,904 184,063 SH   DFND 2 0 0 184,063
CEMPRA INC COM 15130J109 2,728 592,946 SH   DFND 2 0 0 592,946
CENTENE CORP DEL COM 15135B101 16,259 203,544 SH   DFND 2 0 0 203,544
CHEVRON CORP NEW COM 166764100 396 3,800 SH   DFND 2 0 0 3,800
CHEVRON CORP NEW COM 166764100 407 3,900 SH   DFND 1 3,900 0 0
CIGNA CORPORATION COM 125509109 16,216 96,878 SH   DFND 2 0 0 96,878
CITIGROUP INC COM NEW 172967424 364,047 5,443,293 SH   DFND 2 2,014,233 0 3,429,060
CITIGROUP INC COM NEW 172967424 26,466 395,725 SH   DFND 1 395,725 0 0
CLOVIS ONCOLOGY INC COM 189464100 20,932 223,560 SH   DFND 2 0 0 223,560
COCA COLA CO COM 191216100 36,181 806,708 SH   DFND 2 806,708 0 0
COHERUS BIOSCIENCES INC COM 19249H103 3,466 241,505 SH   DFND 2 0 0 241,505
COLGATE PALMOLIVE CO COM 194162103 42,567 574,224 SH   DFND 2 574,224 0 0
CREDICORP LTD COM G2519Y108 134 749 SH   DFND 2 0 0 749
CREDICORP LTD COM G2519Y108 74 412 SH   DFND 1 412 0 0
CROWN CASTLE INTL CORP NEW COM 22822V101 291 2,901 SH   DFND 1 2,901 0 0
CROWN CASTLE INTL CORP NEW COM 22822V101 319 3,184 SH   DFND 2 0 0 3,184
CVS HEALTH CORP COM 126650100 885 11,000 SH   DFND 2 0 0 11,000
CVS HEALTH CORP COM 126650100 923 11,470 SH   DFND 1 11,470 0 0
DERMIRA INC COM 24983L104 3,521 120,815 SH   DFND 2 0 0 120,815
DEX INC COM 252131107 4,469 61,095 SH   DFND 2 0 0 61,095
DYNAVAX TECHNOLOGIES CORP COM NEW 268158201 6,448 668,215 SH   DFND 2 0 0 668,215
EAGLE PHARMACEUTICALS INC COM 269796108 3,845 48,741 SH   DFND 2 0 0 48,741
ECOLAB INC COM 278865100 463,264 3,489,750 SH   DFND 2 1,623,255 0 1,866,495
ECOLAB INC COM 278865100 28,473 214,483 SH   DFND 1 214,483 0 0
EDWARDS LIFESCIENCES CORP COM 28176E108 11,382 96,262 SH   DFND 2 0 0 96,262
ENDOLOGIX INC COM 29266S106 2,435 501,006 SH   DFND 2 0 0 501,006
ESPERION THERAPEUTICS INC NE COM 29664W105 197 4,247 SH   DFND 2 0 0 4,247
EXACT SCIENCES CORP COM 30063P105 5,755 162,710 SH   DFND 2 0 0 162,710
EXELIXIS INC COM 30161Q104 7,270 295,175 SH   DFND 2 0 0 295,175
EXPRESS SCRIPTS HLDG CO COM 30219G108 4,013 62,863 SH   DFND 2 0 0 62,863
FACEBOOK INC CL A 30303M102 395,899 2,622,192 SH   DFND 2 976,437 0 1,645,755
FACEBOOK INC CL A 30303M102 28,565 189,196 SH   DFND 1 189,196 0 0
FIDELITY NATL INFORMATION SV COM 31620M106 348 4,071 SH   DFND 2 0 0 4,071
FIDELITY NATL INFORMATION SV COM 31620M106 338 3,959 SH   DFND 1 3,959 0 0
FIRST REP BK SAN FRANCISCO C COM 33616C100 17,451 174,333 SH   DFND 1 174,333 0 0
FIRST REP BK SAN FRANCISCO C COM 33616C100 298,491 2,981,925 SH   DFND 2 1,510,597 0 1,471,328
FLEX PHARMA INC COM 33938A105 1,071 278,060 SH   DFND 2 0 0 278,060
GILEAD SCIENCES INC COM 375558103 285,068 4,027,525 SH   DFND 2 1,735,328 0 2,292,197
GILEAD SCIENCES INC COM 375558103 15,663 221,294 SH   DFND 1 221,294 0 0
GLAUKOS CORP COM 377322102 10,692 257,831 SH   DFND 2 0 0 257,831
GW PHARMACEUTICALS PLC ADS 36197T103 2,717 27,098 SH   DFND 2 0 0 27,098
HCA HEALTHCARE INC COM 40412C101 11,872 136,152 SH   DFND 2 0 0 136,152
HDFC BANK LTD ADR REPS 3 SHS 40415F101 120,156 1,381,585 SH   DFND 2 1,187,350 0 194,235
HDFC BANK LTD ADR REPS 3 SHS 40415F101 8,521 97,972 SH   DFND 1 97,972 0 0
HOME DEPOT INC COM 437076102 476,372 3,105,425 SH   DFND 2 1,384,115 0 1,721,310
HOME DEPOT INC COM 437076102 30,467 198,610 SH   DFND 1 198,610 0 0
HORIZON PHARMA PLC SHS G4617B105 4,609 388,284 SH   DFND 2 0 0 388,284
ICICI BK LTD ADR 45104G104 40,346 4,497,869 SH   DFND 2 0 0 4,497,869
ICICI BK LTD ADR 45104G104 2,751 306,634 SH   DFND 1 306,634 0 0
INCYTE CORP COM 45337C102 15,578 123,724 SH   DFND 2 0 0 123,724
INGREDION INC COM 457187102 834 7,000 SH   DFND 1 7,000 0 0
INGREDION INC COM 457187102 799 6,700 SH   DFND 2 0 0 6,700
INSMED INC COM PAR $.01 457669307 2,428 141,471 SH   DFND 2 0 0 141,471
INSULET CORP COM 45784P101 5,494 107,065 SH   DFND 2 0 0 107,065
INTERCEPT PHARMACEUTICALS IN COM 45845P108 147 1,216 SH   DFND 2 0 0 1,216
INTERSECT ENT INC COM 46071F103 4,137 147,998 SH   DFND 2 0 0 147,998
INTRA CELLULAR THERAPIES INC COM 46116X101 2,707 217,962 SH   DFND 2 0 0 217,962
IONIS PHARMACEUTICALS INC COM 462222100 282 5,535 SH   DFND 2 0 0 5,535
JAZZ PHARMACEUTICALS PLC SHS USD G50871105 16,335 105,048 SH   DFND 2 0 0 105,048
JOHNSON & JOHNSON COM 478160104 712 5,379 SH   DFND 1 5,379 0 0
JOHNSON & JOHNSON COM 478160104 37,143 280,768 SH   DFND 2 0 0 280,768
JPMORGAN CHASE & CO COM 46625H100 457 5,000 SH   DFND 2 0 0 5,000
JPMORGAN CHASE & CO COM 46625H100 484 5,300 SH   DFND 1 5,300 0 0
K2M GROUP HLDGS INC COM 48273J107 4,472 183,577 SH   DFND 2 0 0 183,577
KARYOPHARM THERAPEUTICS INC COM 48576U106 142 15,678 SH   DFND 2 0 0 15,678
KEMPHARM INC COM 488445107 1,527 381,699 SH   DFND 2 0 0 381,699
KITE PHARMA INC COM 49803L109 6,059 58,443 SH   DFND 2 0 0 58,443
LEXICON PHARMACEUTICALS INC COM NEW 528872302 178 10,793 SH   DFND 2 0 0 10,793
LILLY ELI & CO COM 532457108 10,739 130,484 SH   DFND 2 0 0 130,484
MASTERCARD INCORPORATED CL A 57636Q104 425 3,500 SH   DFND 1 3,500 0 0
MASTERCARD INCORPORATED CL A 57636Q104 1,982 16,319 SH   DFND 2 0 0 16,319
MERCK & CO INC COM 58933Y105 13,335 208,069 SH   DFND 2 0 0 208,069
MICROSOFT CORP COM 594918104 65,792 954,481 SH   DFND 2 954,481 0 0
MONDELEZ INTL INC CL A 609207105 44,820 1,037,745 SH   DFND 2 1,037,745 0 0
MYLAN N V SHS EURO N59465109 7,556 194,639 SH   DFND 2 0 0 194,639
NEOGENOMICS INC COM NEW 64049M209 2,204 246,000 SH   DFND 2 0 0 246,000
NEURODERM LTD ORD SHS M74231107 2,775 92,800 SH   DFND 2 0 0 92,800
NEWLINK GENETICS CORP COM 651511107 73 9,980 SH   DFND 2 0 0 9,980
NIKE INC CL B 654106103 1,922 32,580 SH   DFND 1 32,580 0 0
NIKE INC CL B 654106103 9,319 157,943 SH   DFND 2 0 0 157,943
NOVOCURE LTD ORD SHS G6674U108 4,733 273,600 SH   DFND 2 0 0 273,600
OBALON THERAPEUTICS INC COM 67424L100 2,407 242,893 SH   DFND 2 0 0 242,893
OPEN TEXT CORP COM 683715106 569 13,900 SH   DFND 1 13,900 0 0
OPEN TEXT CORP COM 683715106 634 15,500 SH   DFND 2 0 0 15,500
OXFORD IMMUNOTEC GLOBAL PLC ORD SHS G6855A103 3,064 182,148 SH   DFND 2 0 0 182,148
PARATEK PHARMACEUTICALS INC COM 699374302 10,590 439,400 SH   DFND 2 0 0 439,400
PFENEX INC COM 717071104 984 245,500 SH   DFND 2 0 0 245,500
PFIZER INC COM 717081103 18,418 548,325 SH   DFND 2 0 0 548,325
PFIZER INC COM 717081103 735 21,877 SH   DFND 1 21,877 0 0
PHILIP MORRIS INTL INC COM 718172109 305,354 2,599,860 SH   DFND 2 764,728 0 1,835,132
PHILIP MORRIS INTL INC COM 718172109 28,705 244,398 SH   DFND 1 244,398 0 0
PORTOLA PHARMACEUTICALS INC COM 737010108 5,425 96,590 SH   DFND 2 0 0 96,590
PRICELINE GRP INC COM NEW 741503403 181,850 97,219 SH   DFND 2 35,936 0 61,283
PRICELINE GRP INC COM NEW 741503403 13,266 7,092 SH   DFND 1 7,092 0 0
PUMA BIOTECHNOLOGY INC COM 74587V107 3,481 39,834 SH   DFND 2 0 0 39,834
RADIUS HEALTH INC COM NEW 750469207 280 6,200 SH   DFND 2 0 0 6,200
SAREPTA THERAPEUTICS INC COM 803607100 4,097 121,528 SH   DFND 2 0 0 121,528
SHIRE PLC SPONSORED ADR 82481R106 11,874 71,845 SH   DFND 2 0 0 71,845
SNAP ON INC COM 833034101 954 6,040 SH   DFND 1 6,040 0 0
SNAP ON INC COM 833034101 1,049 6,637 SH   DFND 2 0 0 6,637
SPARK THERAPEUTICS INC COM 84652J103 3,123 52,281 SH   DFND 2 0 0 52,281
SPECTRANETICS CORP COM 84760C107 2,810 73,180 SH   DFND 2 0 0 73,180
SPRING BK PHARMACEUTICALS IN COM 849431101 340 25,123 SH   DFND 2 0 0 25,123
STARBUCKS CORP COM 855244109 50,387 864,125 SH   DFND 2 864,125 0 0
STORE CAP CORP COM 862121100 997 44,423 SH   DFND 2 0 0 44,423
STORE CAP CORP COM 862121100 909 40,488 SH   DFND 1 40,488 0 0
SUPERNUS PHARMACEUTICALS INC COM 868459108 3,089 71,670 SH   DFND 2 0 0 71,670
SYNDAX PHARMACEUTICALS INC COM 87164F105 155 11,100 SH   DFND 2 0 0 11,100
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADR 874039100 53,755 1,537,606 SH   DFND 2 812,306 0 725,300
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADR 874039100 20,777 594,321 SH   DFND 1 594,321 0 0
TESARO INC COM 881569107 6,536 46,732 SH   DFND 2 0 0 46,732
TEVA PHARMACEUTICAL INDS LTD SPONSORED ADR 881624209 8,313 250,231 SH   DFND 2 0 0 250,231
THERMO FISHER SCIENTIFIC INC COM 883556102 358,910 2,057,144 SH   DFND 2 1,000,940 0 1,056,204
THERMO FISHER SCIENTIFIC INC COM 883556102 20,080 115,094 SH   DFND 1 115,094 0 0
TJX COS INC NEW COM 872540109 585 8,100 SH   DFND 1 8,100 0 0
TJX COS INC NEW COM 872540109 650 9,000 SH   DFND 2 0 0 9,000
TORONTO DOMINION BK ONT COM NEW 891160509 1,151 17,618 SH   DFND 1 17,618 0 0
TORONTO DOMINION BK ONT COM NEW 891160509 1,288 19,714 SH   DFND 2 0 0 19,714
TOTAL SYS SVCS INC COM 891906109 285 4,900 SH   DFND 1 4,900 0 0
TOTAL SYS SVCS INC COM 891906109 315 5,400 SH   DFND 2 0 0 5,400
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 4,778 76,927 SH   DFND 2 0 0 76,927
UNITEDHEALTH GROUP INC COM 91324P102 1,020 5,500 SH   DFND 1 5,500 0 0
UNITEDHEALTH GROUP INC COM 91324P102 37,391 201,654 SH   DFND 2 0 0 201,654
VALEANT PHARMACEUTICALS INTL COM 91911K102 3,408 197,010 SH   DFND 2 0 0 197,010
VALERITAS HLDGS INC COM NEW 91914N202 1,603 233,952 SH   DFND 2 0 0 233,952
VERTEX PHARMACEUTICALS INC COM 92532F100 773 6,000 SH   DFND 2 0 0 6,000
VISA INC COM CL A 92826C839 50,760 541,272 SH   DFND 1 541,272 0 0
VISA INC COM CL A 92826C839 783,043 8,349,792 SH   DFND 2 3,774,136 0 4,575,656
WALGREENS BOOTS ALLIANCE INC COM 931427108 776 9,914 SH   DFND 2 0 0 9,914
WALGREENS BOOTS ALLIANCE INC COM 931427108 707 9,033 SH   DFND 1 9,033 0 0
WELLS FARGO CO NEW COM 949746101 304,630 5,497,745 SH   DFND 2 2,695,534 0 2,802,211
WELLS FARGO CO NEW COM 949746101 18,610 335,858 SH   DFND 1 335,858 0 0
WEYERHAEUSER CO COM 962166104 41,648 1,243,221 SH   DFND 2 1,243,221 0 0