The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBVIE INC COM 00287Y109 17,469 260,000 SH   DFND 2 0 0 260,000
ABIOMED INC COM 003654100 3,944 60,000 SH   DFND 2 0 0 60,000
ACADIA HEALTHCARE PANY IN COM 00404A109 3,916 50,000 SH   DFND 2 0 0 50,000
ACADIA PHARMACEUTICALS INC COM 004225108 3,766 89,925 SH   DFND 2 0 0 89,925
ACCELERON PHARMA INC COM 00434H108 554 17,500 SH   DFND 2 0 0 17,500
ACORDA THERAPEUTICS INC COM 00484M106 533 16,000 SH   DFND 2 0 0 16,000
ACTAVIS PLC SHS DELETED G0083B108 40,525 133,542 SH   DFND 2 0 0 133,542
ADVANCED SEMICONDUCTOR ENGR SPONSORED ADR 00756M404 152 23,000 SH   DFND 2 0 0 23,000
ADVANCED SEMICONDUCTOR ENGR SPONSORED ADR 00756M404 136 20,600 SH   DFND 1 20,600 0 0
AERIE PHARMACEUTICALS INC COM 00771V108 5,763 326,503 SH   DFND 2 0 0 326,503
AIR METHODS CORP COM PAR $.06 009128307 13,441 325,136 SH   DFND 2 0 0 325,136
ALEXION PHARMACEUTICALS INC COM 015351109 7,603 42,061 SH   DFND 2 0 0 42,061
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 941 11,440 SH   DFND 1 11,440 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 9,451 114,880 SH   DFND 2 0 0 114,880
ALLIANCE DATA SYSTEMS CORP COM 018581108 165,945 568,420 SH   DFND 2 359,050 0 209,370
ALLIANCE DATA SYSTEMS CORP COM 018581108 13,657 46,780 SH   DFND 1 46,780 0 0
ALPHATEC HOLDINGS INC COM 02081G102 1,226 888,628 SH   DFND 2 0 0 888,628
AMERICAN INTL GROUP INC COM NEW 026874784 279,763 4,525,440 SH   DFND 2 2,865,600 0 1,659,840
AMERICAN INTL GROUP INC COM NEW 026874784 23,714 383,600 SH   DFND 1 383,600 0 0
AMERICAN WTR WKS CO INC NEW COM 030420103 461 9,480 SH   DFND 1 9,480 0 0
AMERICAN WTR WKS CO INC NEW COM 030420103 496 10,200 SH   DFND 2 0 0 10,200
AMERISOURCEBERGEN CORP COM 03073E105 20,036 188,410 SH   DFND 2 0 0 188,410
AMERISOURCEBERGEN CORP COM 03073E105 297 2,790 SH   DFND 1 2,790 0 0
AMGEN INC COM 031162100 38,877 253,238 SH   DFND 2 0 0 253,238
AON PLC SHS CL A G0408V102 389 3,900 SH   DFND 2 0 0 3,900
AON PLC SHS CL A G0408V102 255 2,560 SH   DFND 1 2,560 0 0
ATHENAHEALTH INC COM 04685W103 2,432 21,222 SH   DFND 2 0 0 21,222
AUTOZONE INC COM 053332102 534 800 SH   DFND 2 0 0 800
AUTOZONE INC COM 053332102 351 527 SH   DFND 1 527 0 0
BAIDU INC SPON ADR REP A 056752108 9,110 45,760 SH   DFND 2 0 0 45,760
BAIDU INC SPON ADR REP A 056752108 969 4,865 SH   DFND 1 4,865 0 0
BCE INC COM NEW 05534B760 615 11,600 SH   DFND 2 0 0 11,600
BCE INC COM NEW 05534B760 402 7,580 SH   DFND 1 7,580 0 0
BIOGEN INC COM 09062X103 39,987 98,992 SH   DFND 2 0 0 98,992
BIOMARIN PHARMACEUTICAL INC COM 09061G101 10,243 74,885 SH   DFND 2 0 0 74,885
BOSTON SCIENTIFIC CORP COM 101137107 2,655 150,000 SH   DFND 2 0 0 150,000
CARA THERAPEUTICS INC COM 140755109 3,485 286,841 SH   DFND 2 0 0 286,841
CELGENE CORP COM 151020104 50,349 435,038 SH   DFND 2 0 0 435,038
CEMPRA INC COM 15130J109 25,918 754,300 SH   DFND 2 0 0 754,300
CENTENE CORP DEL COM 15135B101 27,867 346,600 SH   DFND 2 0 0 346,600
CEPHEID COM 15670R107 5,504 90,000 SH   DFND 2 0 0 90,000
CERNER CORP COM 156782104 635 9,200 SH   DFND 1 9,200 0 0
CERNER CORP COM 156782104 4,895 70,878 SH   DFND 2 0 0 70,878
CHIMERIX INC COM 16934W106 12,659 274,000 SH   DFND 2 0 0 274,000
CIGNA CORPORATION COM 125509109 20,509 126,600 SH   DFND 2 0 0 126,600
CITIGROUP INC COM NEW 172967424 23,074 417,700 SH   DFND 1 417,700 0 0
CITIGROUP INC COM NEW 172967424 274,109 4,962,150 SH   DFND 2 3,153,300 0 1,808,850
COHERUS BIOSCIENCES INC COM 19249H103 1,734 60,000 SH   DFND 2 0 0 60,000
COMCAST CORP NEW CL A 20030N101 511 8,500 SH   DFND 2 0 0 8,500
COMCAST CORP NEW CL A 20030N101 565 9,390 SH   DFND 1 9,390 0 0
COOPER COS INC COM NEW 216648402 16,338 91,800 SH   DFND 2 0 0 91,800
CREDICORP LTD COM G2519Y108 58 415 SH   DFND 1 415 0 0
CREDICORP LTD COM G2519Y108 67 485 SH   DFND 2 0 0 485
CVS HEALTH CORP COM 126650100 343,601 3,276,130 SH   DFND 2 2,059,800 0 1,216,330
CVS HEALTH CORP COM 126650100 30,832 293,970 SH   DFND 1 293,970 0 0
DANAHER CORP DEL COM 235851102 836 9,770 SH   DFND 1 9,770 0 0
DANAHER CORP DEL COM 235851102 924 10,800 SH   DFND 2 0 0 10,800
DAVITA HEALTHCARE PARTNERS I COM 23918K108 7,827 98,491 SH   DFND 2 0 0 98,491
DEX INC COM 252131107 5,993 74,925 SH   DFND 2 0 0 74,925
DISCOVER FINL SVCS COM 254709108 490 8,500 SH   DFND 2 0 0 8,500
DISCOVER FINL SVCS COM 254709108 438 7,610 SH   DFND 1 7,610 0 0
DISNEY WALT CO COM DISNEY 254687106 34,042 298,244 SH   DFND 1 298,244 0 0
DISNEY WALT CO COM DISNEY 254687106 399,217 3,497,610 SH   DFND 2 2,205,400 0 1,292,210
DR PEPPER SNAPPLE GROUP INC COM 26138E109 382 5,240 SH   DFND 1 5,240 0 0
DR PEPPER SNAPPLE GROUP INC COM 26138E109 357 4,900 SH   DFND 2 0 0 4,900
DUKE ENERGY CORP NEW COM NEW 26441C204 417 5,900 SH   DFND 1 5,900 0 0
DUKE ENERGY CORP NEW COM NEW 26441C204 311 4,400 SH   DFND 2 0 0 4,400
DYNAVAX TECHNOLOGIES CORP COM NEW 268158201 3,677 156,962 SH   DFND 2 0 0 156,962
EAGLE PHARMACEUTICALS INC COM 269796108 22,593 279,407 SH   DFND 2 0 0 279,407
ECOLAB INC COM 278865100 276,989 2,449,711 SH   DFND 2 1,555,900 0 893,811
ECOLAB INC COM 278865100 23,880 211,200 SH   DFND 1 211,200 0 0
EDISON INTL COM 281020107 750 13,500 SH   DFND 1 13,500 0 0
EDISON INTL COM 281020107 745 13,400 SH   DFND 2 0 0 13,400
ENDO INTL PLC SHS G30401106 2,788 35,000 SH   DFND 2 0 0 35,000
ESPERION THERAPEUTICS INC NE COM 29664W105 646 7,900 SH   DFND 2 0 0 7,900
EXACT SCIENCES CORP COM 30063P105 6,543 220,000 SH   DFND 2 0 0 220,000
EXAMWORKS GROUP INC COM 30066A105 3,519 90,000 SH   DFND 2 0 0 90,000
EXPRESS SCRIPTS HLDG CO COM 30219G108 18,420 207,101 SH   DFND 2 0 0 207,101
EXPRESS SCRIPTS HLDG CO COM 30219G108 587 6,600 SH   DFND 1 6,600 0 0
FACEBOOK INC CL A 30303M102 272,460 3,176,825 SH   DFND 2 2,018,200 0 1,158,625
FACEBOOK INC CL A 30303M102 22,820 266,075 SH   DFND 1 266,075 0 0
FISERV INC COM 337738108 376 4,540 SH   DFND 1 4,540 0 0
FISERV INC COM 337738108 572 6,900 SH   DFND 2 0 0 6,900
GILEAD SCIENCES INC COM 375558103 456,014 3,894,892 SH   DFND 2 2,048,900 0 1,845,992
GILEAD SCIENCES INC COM 375558103 33,221 283,750 SH   DFND 1 283,750 0 0
GOOGLE INC CL A 38259P508 114,372 211,784 SH   DFND 2 136,670 0 75,114
GOOGLE INC CL A 38259P508 10,974 20,320 SH   DFND 1 20,320 0 0
GOOGLE INC CL C 38259P706 229,872 441,629 SH   DFND 2 274,778 0 166,851
GOOGLE INC CL C 38259P706 18,208 34,981 SH   DFND 1 34,981 0 0
HCA HOLDINGS INC COM 40412C101 13,542 149,275 SH   DFND 2 0 0 149,275
HDFC BANK LTD ADR REPS 3 SHS 40415F101 240,247 3,969,050 SH   DFND 2 3,868,800 0 100,250
HDFC BANK LTD ADR REPS 3 SHS 40415F101 5,940 98,140 SH   DFND 1 98,140 0 0
HOME DEPOT INC COM 437076102 378,066 3,402,020 SH   DFND 2 2,141,400 0 1,260,620
HOME DEPOT INC COM 437076102 33,463 301,120 SH   DFND 1 301,120 0 0
HUMANA INC COM 444859102 2,831 14,800 SH   DFND 2 0 0 14,800
ICICI BK LTD ADR 45104G104 24,389 2,340,590 SH   DFND 2 0 0 2,340,590
ICICI BK LTD ADR 45104G104 2,366 227,100 SH   DFND 1 227,100 0 0
IKANG HEALTHCARE GROUP INC SPONSORED ADR 45174L108 3,094 160,000 SH   DFND 2 0 0 160,000
INNOCOLL AG SPONSORED ADR 45780Q103 3,587 245,184 SH   DFND 2 0 0 245,184
INSULET CORP COM 45784P101 6,600 213,000 SH   DFND 2 0 0 213,000
INTERCEPT PHARMACEUTICALS IN COM 45845P108 797 3,300 SH   DFND 2 0 0 3,300
ISIS PHARMACEUTICALS INC COM 464330109 5,220 90,700 SH   DFND 2 0 0 90,700
JAZZ PHARMACEUTICALS PLC SHS USD G50871105 17,922 101,787 SH   DFND 2 0 0 101,787
JOHNSON & JOHNSON COM 478160104 30,815 316,186 SH   DFND 2 0 0 316,186
JOHNSON & JOHNSON COM 478160104 708 7,265 SH   DFND 1 7,265 0 0
JPMORGAN CHASE & CO COM 46625H100 745 11,000 SH   DFND 1 11,000 0 0
JPMORGAN CHASE & CO COM 46625H100 779 11,500 SH   DFND 2 0 0 11,500
K2M GROUP HLDGS INC COM 48273J107 2,430 101,151 SH   DFND 2 0 0 101,151
KERYX BIOPHARMACEUTICALS INC COM 492515101 4,192 420,000 SH   DFND 2 0 0 420,000
KITE PHARMA INC COM 49803L109 1,524 25,000 SH   DFND 2 0 0 25,000
L BRANDS INC COM 501797104 332,424 3,877,565 SH   DFND 2 2,440,100 0 1,437,465
L BRANDS INC COM 501797104 28,063 327,340 SH   DFND 1 327,340 0 0
LDR HLDG CORP COM 50185U105 5,057 116,917 SH   DFND 2 0 0 116,917
MASTERCARD INC CL A 57636Q104 2,244 24,000 SH   DFND 2 0 0 24,000
MCKESSON CORP COM 58155Q103 201,541 896,495 SH   DFND 2 562,720 0 333,775
MCKESSON CORP COM 58155Q103 17,458 77,655 SH   DFND 1 77,655 0 0
MEDIVATION INC COM 58501N101 5,009 43,861 SH   DFND 2 0 0 43,861
MEDNAX INC COM 58502B106 3,258 43,962 SH   DFND 2 0 0 43,962
MEDNAX INC COM 58502B106 593 8,000 SH   DFND 1 8,000 0 0
MEDTRONIC PLC SHS G5960L103 711 9,600 SH   DFND 2 0 0 9,600
MEDTRONIC PLC SHS G5960L103 467 6,300 SH   DFND 1 6,300 0 0
MERCK & CO INC NEW COM 58933Y105 20,961 368,197 SH   DFND 2 0 0 368,197
MIMEDX GROUP INC COM 602496101 4,404 380,000 SH   DFND 2 0 0 380,000
MONDELEZ INTL INC CL A 609207105 531 12,900 SH   DFND 2 0 0 12,900
MONDELEZ INTL INC CL A 609207105 560 13,600 SH   DFND 1 13,600 0 0
MONSANTO CO NEW COM 61166W101 512 4,800 SH   DFND 2 0 0 4,800
MONSANTO CO NEW COM 61166W101 494 4,630 SH   DFND 1 4,630 0 0
NEWLINK GENETICS CORP COM 651511107 576 13,000 SH   DFND 2 0 0 13,000
NIKE INC CL B 654106103 6,292 58,250 SH   DFND 2 0 0 58,250
NIKE INC CL B 654106103 1,943 17,990 SH   DFND 1 17,990 0 0
NOVADAQ TECHNOLOGIES INC COM 66987G102 3,028 250,000 SH   DFND 2 0 0 250,000
NUVASIVE INC COM 670704105 4,177 88,160 SH   DFND 2 0 0 88,160
OXFORD IMMUNOTEC GLOBAL PLC ORD SHS G6855A103 1,668 120,460 SH   DFND 2 0 0 120,460
PFIZER INC COM 717081103 18,754 559,315 SH   DFND 2 0 0 559,315
PG&E CORP COM 69331C108 358 7,300 SH   DFND 2 0 0 7,300
PG&E CORP COM 69331C108 236 4,810 SH   DFND 1 4,810 0 0
PHILIP MORRIS INTL INC COM 718172109 227 2,835 SH   DFND 1 2,835 0 0
PHILIP MORRIS INTL INC COM 718172109 345 4,300 SH   DFND 2 0 0 4,300
PORTOLA PHARMACEUTICALS INC COM 737010108 3,508 77,013 SH   DFND 2 0 0 77,013
RADIUS HEALTH INC COM NEW 750469207 1,219 18,000 SH   DFND 2 0 0 18,000
REGENERON PHARMACEUTICALS COM 75886F107 1,709 3,350 SH   DFND 2 0 0 3,350
REGULUS THERAPEUTICS INC COM 75915K101 1,534 140,000 SH   DFND 2 0 0 140,000
RELYPSA INC COM 759531106 4,633 140,000 SH   DFND 2 0 0 140,000
REPROS THERAPEUTICS INC COM NEW 76028H209 1,430 200,000 SH   DFND 2 0 0 200,000
ROSS STORES INC COM 778296103 408 8,400 SH   DFND 2 0 0 8,400
ROSS STORES INC COM 778296103 276 5,680 SH   DFND 1 5,680 0 0
SENSATA TECHNOLOGIES HLDG NV SHS N7902X106 159,531 3,024,860 SH   DFND 2 1,980,600 0 1,044,260
SENSATA TECHNOLOGIES HLDG NV SHS N7902X106 12,447 236,000 SH   DFND 1 236,000 0 0
SHIRE PLC SPONSORED ADR 82481R106 11,159 46,209 SH   DFND 2 0 0 46,209
SNAP ON INC COM 833034101 514 3,230 SH   DFND 1 3,230 0 0
SNAP ON INC COM 833034101 780 4,900 SH   DFND 2 0 0 4,900
SORRENTO THERAPEUTICS INC COM NEW 83587F202 3,917 222,301 SH   DFND 2 0 0 222,301
SPARK THERAPEUTICS INC COM 84652J103 3,737 62,000 SH   DFND 2 0 0 62,000
SPECTRANETICS CORP COM 84760C107 3,543 153,956 SH   DFND 2 0 0 153,956
STRYKER CORP COM 863667101 487 5,100 SH   DFND 2 0 0 5,100
STRYKER CORP COM 863667101 321 3,360 SH   DFND 1 3,360 0 0
SUPERNUS PHARMACEUTICALS INC COM 868459108 4,924 290,000 SH   DFND 2 0 0 290,000
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADR 874039100 294 12,960 SH   DFND 1 12,960 0 0
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADR 874039100 3,954 174,100 SH   DFND 2 159,100 0 15,000
TD AMERITRADE HLDG CORP COM 87236Y108 189,599 5,149,350 SH   DFND 2 3,269,800 0 1,879,550
TD AMERITRADE HLDG CORP COM 87236Y108 15,450 419,600 SH   DFND 1 419,600 0 0
TETRAPHASE PHARMACEUTICALS I COM 88165N105 23,340 492,000 SH   DFND 2 0 0 492,000
TEVA PHARMACEUTICAL INDS LTD ADR 881624209 13,948 236,000 SH   DFND 2 0 0 236,000
THERMO FISHER SCIENTIFIC INC COM 883556102 480 3,700 SH   DFND 2 0 0 3,700
THERMO FISHER SCIENTIFIC INC COM 883556102 472 3,640 SH   DFND 1 3,640 0 0
TORONTO DOMINION BK ONT COM NEW 891160509 971 18,300 SH   DFND 2 0 0 18,300
TORONTO DOMINION BK ONT COM NEW 891160509 871 16,420 SH   DFND 1 16,420 0 0
TRANSENTERIX INC COM NEW 89366M201 1,912 637,169 SH   DFND 2 0 0 637,169
TROVAGENE INC COM NEW 897238309 2,828 278,584 SH   DFND 2 0 0 278,584
UNION PAC CORP COM 907818108 344,267 3,609,800 SH   DFND 2 2,295,100 0 1,314,700
UNION PAC CORP COM 907818108 29,483 309,140 SH   DFND 1 309,140 0 0
UNITEDHEALTH GROUP INC COM 91324P102 42,841 351,158 SH   DFND 2 0 0 351,158
VALEANT PHARMACEUTICALS INTL COM 91911K102 32,425 145,961 SH   DFND 2 0 0 145,961
VERIZON MUNICATIONS INC COM 92343V104 545 11,690 SH   DFND 1 11,690 0 0
VERIZON MUNICATIONS INC COM 92343V104 587 12,600 SH   DFND 2 0 0 12,600
VERTEX PHARMACEUTICALS INC COM 92532F100 2,797 22,650 SH   DFND 2 0 0 22,650
VISA INC COM CL A 92826C839 670,733 9,988,580 SH   DFND 2 6,313,000 0 3,675,580
VISA INC COM CL A 92826C839 57,327 853,720 SH   DFND 1 853,720 0 0
WELLCARE HEALTH PLANS INC COM 94946T106 3,393 40,000 SH   DFND 2 0 0 40,000
WELLS FARGO & CO NEW COM 949746101 323,033 5,743,838 SH   DFND 2 3,605,300 0 2,138,538
WELLS FARGO & CO NEW COM 949746101 28,102 499,680 SH   DFND 1 499,680 0 0
ZIMMER BIOMET HLDGS INC COM 98956P102 8,677 79,441 SH   DFND 2 0 0 79,441