The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBVIE INC COM 00287Y109 15,220 260,000 SH   DFND 2 0 0 260,000
ABIOMED INC COM 003654100 6,076 84,888 SH   DFND 2 0 0 84,888
ACADIA HEALTHCARE PANY IN COM 00404A109 3,580 50,000 SH   DFND 2 0 0 50,000
ACADIA PHARMACEUTICALS INC COM 004225108 2,931 89,925 SH   DFND 2 0 0 89,925
ACCELERON PHARMA INC COM 00434H108 400 10,500 SH   DFND 2 0 0 10,500
ACCENTURE PLC IRELAND SHS CLASS A G1151C101 128 1,370 SH   DFND 1 1,370 0 0
ACORDA THERAPEUTICS INC COM 00484M106 532 16,000 SH   DFND 2 0 0 16,000
ACTAVIS PLC SHS G0083B108 33,495 112,542 SH   DFND 2 0 0 112,542
ADVANCED SEMICONDUCTOR ENGR SPONSORED ADR 00756M404 148 20,600 SH   DFND 1 20,600 0 0
AEGERION PHARMACEUTICALS INC COM 00767E102 1,464 55,940 SH   DFND 2 0 0 55,940
AERIE PHARMACEUTICALS INC COM 00771V108 2,849 90,903 SH   DFND 2 0 0 90,903
AIR METHODS CORP COM PAR $.06 009128307 15,614 335,136 SH   DFND 2 0 0 335,136
ALEXION PHARMACEUTICALS INC COM 015351109 8,086 46,661 SH   DFND 2 0 0 46,661
ALEXZA PHARMACEUTICALS INC COM NEW 015384209 829 400,273 SH   DFND 2 0 0 400,273
ALLIANCE DATA SYSTEMS CORP COM 018581108 173,131 584,410 SH   DFND 2 372,450 0 211,960
ALLIANCE DATA SYSTEMS CORP COM 018581108 14,496 48,930 SH   DFND 1 48,930 0 0
ALPHATEC HOLDINGS INC COM 02081G102 1,289 888,628 SH   DFND 2 0 0 888,628
AMERICAN INTL GROUP INC COM NEW 026874784 251,713 4,594,140 SH   DFND 2 2,913,200 0 1,680,940
AMERICAN INTL GROUP INC COM NEW 026874784 21,248 387,800 SH   DFND 1 387,800 0 0
AMERICAN WTR WKS CO INC NEW COM 030420103 362 6,680 SH   DFND 1 6,680 0 0
AMERISOURCEBERGEN CORP COM 03073E105 20,928 184,110 SH   DFND 2 0 0 184,110
AMERISOURCEBERGEN CORP COM 03073E105 317 2,790 SH   DFND 1 2,790 0 0
AMGEN INC COM 031162100 40,480 253,238 SH   DFND 2 0 0 253,238
AON PLC SHS CL A G0408V102 121 1,260 SH   DFND 1 1,260 0 0
ATHENAHEALTH INC COM 04685W103 3,728 31,222 SH   DFND 2 0 0 31,222
AUSPEX PHARMACEUTICALS INC COM 05211J102 1,554 15,500 SH   DFND 2 0 0 15,500
AUTOZONE INC COM 053332102 359 527 SH   DFND 1 527 0 0
BAIDU INC SPON ADR REP A 056752108 9,190 44,100 SH   DFND 2 0 0 44,100
BAIDU INC SPON ADR REP A 056752108 1,003 4,815 SH   DFND 1 4,815 0 0
BCE INC COM NEW 05534B760 406 7,580 SH   DFND 1 7,580 0 0
BIOGEN INC COM 09062X103 38,252 90,592 SH   DFND 2 0 0 90,592
BIOMARIN PHARMACEUTICAL INC COM 09061G101 9,332 74,885 SH   DFND 2 0 0 74,885
CARA THERAPEUTICS INC COM 140755109 2,802 278,841 SH   DFND 2 0 0 278,841
CELGENE CORP COM 151020104 39,638 343,838 SH   DFND 2 0 0 343,838
CELLADON CORP COM 15117E107 5,682 300,000 SH   DFND 2 0 0 300,000
CEMPRA INC COM 15130J109 19,557 570,000 SH   DFND 2 0 0 570,000
CENTENE CORP DEL COM 15135B101 22,395 316,800 SH   DFND 2 0 0 316,800
CEPHEID COM 15670R107 5,974 105,000 SH   DFND 2 0 0 105,000
CERNER CORP COM 156782104 4,687 63,978 SH   DFND 2 0 0 63,978
CHIMERIX INC COM 16934W106 9,234 245,000 SH   DFND 2 0 0 245,000
CITIGROUP INC COM NEW 172967424 259,509 5,037,050 SH   DFND 2 3,206,500 0 1,830,550
CITIGROUP INC COM NEW 172967424 22,288 432,600 SH   DFND 1 432,600 0 0
COLGATE PALMOLIVE CO COM 194162103 319 4,600 SH   DFND 1 4,600 0 0
COMCAST CORP NEW CL A 20030N101 316 5,590 SH   DFND 1 5,590 0 0
CREDICORP LTD COM G2519Y108 58 415 SH   DFND 1 415 0 0
CVS HEALTH CORP COM 126650100 342,485 3,318,330 SH   DFND 2 2,093,700 0 1,224,630
CVS HEALTH CORP COM 126650100 29,536 286,170 SH   DFND 1 286,170 0 0
DANAHER CORP DEL COM 235851102 354 4,170 SH   DFND 1 4,170 0 0
DAVITA HEALTHCARE PARTNERS I COM 23918K108 8,005 98,491 SH   DFND 2 0 0 98,491
DEX INC COM 252131107 4,983 79,925 SH   DFND 2 0 0 79,925
DISCOVER FINL SVCS COM 254709108 220 3,910 SH   DFND 1 3,910 0 0
DISNEY WALT CO COM DISNEY 254687106 371,930 3,545,910 SH   DFND 2 2,241,800 0 1,304,110
DISNEY WALT CO COM DISNEY 254687106 31,403 299,394 SH   DFND 1 299,394 0 0
DR PEPPER SNAPPLE GROUP INC COM 26138E109 127 1,620 SH   DFND 1 1,620 0 0
DYNAVAX TECHNOLOGIES CORP COM NEW 268158201 2,803 124,962 SH   DFND 2 0 0 124,962
EAGLE PHARMACEUTICALS INC COM 269796108 5,630 134,407 SH   DFND 2 0 0 134,407
ECOLAB INC COM 278865100 284,533 2,487,611 SH   DFND 2 1,582,600 0 905,011
ECOLAB INC COM 278865100 23,985 209,700 SH   DFND 1 209,700 0 0
EDISON INTL COM 281020107 278 4,450 SH   DFND 1 4,450 0 0
ELEVEN BIOTHERAPEUTICS INC COM 286221106 1,494 167,434 SH   DFND 2 0 0 167,434
ENBRIDGE INC COM 29250N105 242 5,000 SH   DFND 1 5,000 0 0
EVOKE PHARMA INC COM 30049G104 318 45,100 SH   DFND 2 0 0 45,100
EXACT SCIENCES CORP COM 30063P105 4,844 220,000 SH   DFND 2 0 0 220,000
EXAMWORKS GROUP INC COM 30066A105 4,367 104,925 SH   DFND 2 0 0 104,925
EXPRESS SCRIPTS HLDG CO COM 30219G108 17,337 199,801 SH   DFND 2 0 0 199,801
EXPRESS SCRIPTS HLDG CO COM 30219G108 416 4,800 SH   DFND 1 4,800 0 0
FACEBOOK INC CL A 30303M102 265,581 3,230,325 SH   DFND 2 2,051,400 0 1,178,925
FACEBOOK INC CL A 30303M102 22,155 269,475 SH   DFND 1 269,475 0 0
FISERV INC COM 337738108 360 4,540 SH   DFND 1 4,540 0 0
GENERAL MLS INC COM 370334104 215 3,800 SH   DFND 2 0 0 3,800
GILEAD SCIENCES INC COM 375558103 384,002 3,913,192 SH   DFND 2 2,082,900 0 1,830,292
GILEAD SCIENCES INC COM 375558103 27,447 279,700 SH   DFND 1 279,700 0 0
GOLDCORP INC NEW COM 380956409 192 10,600 SH   DFND 1 10,600 0 0
GOOGLE INC CL A 38259P508 170,825 307,959 SH   DFND 2 197,470 0 110,489
GOOGLE INC CL A 38259P508 14,988 27,020 SH   DFND 1 27,020 0 0
GOOGLE INC CL C 38259P706 239,281 436,644 SH   DFND 2 274,030 0 162,614
GOOGLE INC CL C 38259P706 18,789 34,287 SH   DFND 1 34,287 0 0
HCA HOLDINGS INC COM 40412C101 11,230 149,275 SH   DFND 2 0 0 149,275
HDFC BANK LTD ADR REPS 3 SHS 40415F101 251,281 4,266,950 SH   DFND 2 4,178,500 0 88,450
HDFC BANK LTD ADR REPS 3 SHS 40415F101 5,361 91,040 SH   DFND 1 91,040 0 0
HOME DEPOT INC COM 437076102 391,656 3,447,370 SH   DFND 2 2,176,000 0 1,271,370
HOME DEPOT INC COM 437076102 33,608 295,820 SH   DFND 1 295,820 0 0
HORMEL FOODS CORP COM 440452100 351 6,180 SH   DFND 1 6,180 0 0
ICICI BK LTD ADR 45104G104 23,461 2,264,590 SH   DFND 2 0 0 2,264,590
ICICI BK LTD ADR 45104G104 2,431 234,700 SH   DFND 1 234,700 0 0
INFOSYS LTD SPONSORED ADR 456788108 118 3,360 SH   DFND 1 3,360 0 0
INNOCOLL AG SPONSORED ADR 45780Q103 1,841 245,184 SH   DFND 2 0 0 245,184
INSULET CORP COM 45784P101 6,437 193,000 SH   DFND 2 0 0 193,000
ISIS PHARMACEUTICALS INC COM 464330109 6,246 98,100 SH   DFND 2 0 0 98,100
JAZZ PHARMACEUTICALS PLC SHS USD G50871105 17,415 100,787 SH   DFND 2 0 0 100,787
JOHNSON & JOHNSON COM 478160104 41,567 413,186 SH   DFND 2 0 0 413,186
JOHNSON & JOHNSON COM 478160104 530 5,265 SH   DFND 1 5,265 0 0
K2M GROUP HLDGS INC COM 48273J107 2,230 101,151 SH   DFND 2 0 0 101,151
KERYX BIOPHARMACEUTICALS INC COM 492515101 11,588 910,302 SH   DFND 2 0 0 910,302
KITE PHARMA INC COM 49803L109 2,099 35,000 SH   DFND 2 0 0 35,000
KYTHERA BIOPHARMACEUTICALS I COM 501570105 4,088 81,517 SH   DFND 2 0 0 81,517
L BRANDS INC COM 501797104 370,786 3,932,395 SH   DFND 2 2,481,000 0 1,451,395
L BRANDS INC COM 501797104 31,412 333,140 SH   DFND 1 333,140 0 0
LDR HLDG CORP COM 50185U105 5,017 136,917 SH   DFND 2 0 0 136,917
LORILLARD INC COM 544147101 2,418 37,000 SH   DFND 2 0 0 37,000
LUMENIS LTD SHS CL B M6778Q121 1,664 139,014 SH   DFND 2 0 0 139,014
MASTERCARD INC CL A 57636Q104 2,073 24,000 SH   DFND 2 0 0 24,000
MCKESSON CORP COM 58155Q103 205,649 909,145 SH   DFND 2 572,320 0 336,825
MCKESSON CORP COM 58155Q103 17,509 77,405 SH   DFND 1 77,405 0 0
MEDIVATION INC COM 58501N101 13,034 100,982 SH   DFND 2 0 0 100,982
MEDNAX INC COM 58502B106 2,535 34,962 SH   DFND 2 0 0 34,962
MEDTRONIC PLC SHS ADDED G5960L103 281 3,600 SH   DFND 1 3,600 0 0
MERCK & CO INC NEW COM 58933Y105 26,912 468,197 SH   DFND 2 0 0 468,197
MIMEDX GROUP INC COM 602496101 4,160 400,000 SH   DFND 2 0 0 400,000
MONSANTO CO NEW COM 61166W101 352 3,130 SH   DFND 1 3,130 0 0
MYLAN INC COM DELETED 628530107 20,594 346,999 SH   DFND 2 0 0 346,999
NEWLINK GENETICS CORP COM 651511107 711 13,000 SH   DFND 2 0 0 13,000
NIKE INC CL B 654106103 5,844 58,250 SH   DFND 2 0 0 58,250
NIKE INC CL B 654106103 1,685 16,790 SH   DFND 1 16,790 0 0
NUVASIVE INC COM 670704105 4,744 103,160 SH   DFND 2 0 0 103,160
OXFORD IMMUNOTEC GLOBAL PLC ORD SHS G6855A103 1,696 120,460 SH   DFND 2 0 0 120,460
PFIZER INC COM 717081103 36,053 1,036,315 SH   DFND 2 0 0 1,036,315
PG&E CORP COM 69331C108 255 4,810 SH   DFND 1 4,810 0 0
PHILIP MORRIS INTL INC COM 718172109 214 2,835 SH   DFND 1 2,835 0 0
PORTOLA PHARMACEUTICALS INC COM 737010108 2,354 62,013 SH   DFND 2 0 0 62,013
PRAXAIR INC COM 74005P104 210,074 1,739,890 SH   DFND 2 1,109,700 0 630,190
PRAXAIR INC COM 74005P104 18,022 149,260 SH   DFND 1 149,260 0 0
QIWI PLC SPON ADR REP B 74735M108 429 17,875 SH   DFND 2 0 0 17,875
REGENERON PHARMACEUTICALS COM 75886F107 1,512 3,350 SH   DFND 2 0 0 3,350
RELYPSA INC COM 759531106 4,328 120,000 SH   DFND 2 0 0 120,000
REPROS THERAPEUTICS INC COM NEW 76028H209 1,718 200,000 SH   DFND 2 0 0 200,000
ROSS STORES INC COM 778296103 152 1,440 SH   DFND 1 1,440 0 0
SERVICE CORP INTL COM 817565104 461 17,700 SH   DFND 1 17,700 0 0
SHIRE PLC SPONSORED ADR 82481R106 11,057 46,209 SH   DFND 2 0 0 46,209
SNAP ON INC COM 833034101 321 2,180 SH   DFND 1 2,180 0 0
SORRENTO THERAPEUTICS INC COM NEW 83587F202 3,032 262,301 SH   DFND 2 0 0 262,301
SPARK THERAPEUTICS INC COM ADDED 84652J103 2,868 37,000 SH   DFND 2 0 0 37,000
SPECTRANETICS CORP COM 84760C107 4,309 123,956 SH   DFND 2 0 0 123,956
STARBUCKS CORP COM 855244109 303 3,200 SH   DFND 1 3,200 0 0
STRYKER CORP COM 863667101 310 3,360 SH   DFND 1 3,360 0 0
SUPERNUS PHARMACEUTICALS INC COM 868459108 4,594 380,000 SH   DFND 2 0 0 380,000
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADR 874039100 3,736 159,100 SH   DFND 2 159,100 0 0
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADR 874039100 304 12,960 SH   DFND 1 12,960 0 0
TATA MTRS LTD SPONSORED ADR 876568502 223 4,950 SH   DFND 1 4,950 0 0
TD AMERITRADE HLDG CORP COM 87236Y108 195,788 5,254,650 SH   DFND 2 3,353,100 0 1,901,550
TD AMERITRADE HLDG CORP COM 87236Y108 15,664 420,400 SH   DFND 1 420,400 0 0
TETRAPHASE PHARMACEUTICALS I COM 88165N105 17,807 486,000 SH   DFND 2 0 0 486,000
TEVA PHARMACEUTICAL INDS LTD ADR 881624209 2,243 36,000 SH   DFND 2 0 0 36,000
THERMO FISHER SCIENTIFIC INC COM 883556102 120 890 SH   DFND 1 890 0 0
TORONTO DOMINION BK ONT COM NEW 891160509 522 9,620 SH   DFND 1 9,620 0 0
TRANSENTERIX INC COM NEW 89366M201 1,867 637,169 SH   DFND 2 0 0 637,169
TROVAGENE INC COM NEW 897238309 1,625 238,584 SH   DFND 2 0 0 238,584
UNION PAC CORP COM 907818108 397,043 3,665,800 SH   DFND 2 2,333,600 0 1,332,200
UNION PAC CORP COM 907818108 33,343 307,850 SH   DFND 1 307,850 0 0
UNITEDHEALTH GROUP INC COM 91324P102 41,538 351,158 SH   DFND 2 0 0 351,158
VALEANT PHARMACEUTICALS INTL COM 91911K102 26,051 131,161 SH   DFND 2 0 0 131,161
VERIZON MUNICATIONS INC COM 92343V104 403 8,290 SH   DFND 1 8,290 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 2,525 21,400 SH   DFND 2 0 0 21,400
VISA INC COM CL A 92826C839 663,577 10,144,880 SH   DFND 2 6,419,200 0 3,725,680
VISA INC COM CL A 92826C839 55,796 853,020 SH   DFND 1 853,020 0 0
WELLCARE HEALTH PLANS INC COM 94946T106 5,030 55,000 SH   DFND 2 0 0 55,000
WELLS FARGO & CO NEW COM 949746101 27,199 499,980 SH   DFND 1 499,980 0 0
WELLS FARGO & CO NEW COM 949746101 316,246 5,813,338 SH   DFND 2 3,665,800 0 2,147,538
YANDEX N V SHS CLASS A N97284108 229 15,100 SH   DFND 2 0 0 15,100
ZIMMER HLDGS INC COM 98956P102 9,336 79,441 SH   DFND 2 0 0 79,441