14. Selected Quarterly Financial Data (Unaudited)

During the quarters ended March 31, June 30 and September 30, 2017, patent legal costs of $0.1 million, $0.2 million and $0.3 million, respectively, were reclassified from research and development costs to general and administrative costs. These changes did not impact loss from operations or net loss. The selected financial data below has been adjusted for such reclassifications.

The following table provides the selected quarterly financial data for the years ended December 31, 2018 and 2017 (in thousands, except per share data):


	Quarter Ended
	2018								2017
	December 31,		September 30,		June 30,		March 31,		December 31,		September 30,		June 30,		March 31,
Revenue	$	—	$	—	$	—	$	—	$	—	$	—	$	—	$	—
Operating expenses:
General and administrative		3,814		5,675		5,173		5,383		5,801		4,434		3,924		1,344
Research and development		5,080		5,038		3,960		3,175		2,864		2,925		2,130		1,727
Amortization of intangible assets		166		166		167		166		166		166		167		166
Total operating expenses		9,060		10,879		9,300		8,724		8,831		7,525		6,221		3,237
Other income (expense):
Interest income		135		118		137		56		128		39		41		39
Other expense		(28)		—		—		—		—		—		—		—
Total other income (expense)		107		118		137		56		128		39		41		39
Loss from operations, before income taxes		(8,953)		(10,761)		(9,163)		(8,668)		(8,703)		(7,486)		(6,180)		(3,198)
Income tax benefit		—		—		—		—		—		—		—		—
Net loss		(8,953)		(10,761)		(9,163)		(8,668)		(8,703)		(7,486)		(6,180)		(3,198)
Other comprehensive loss:
Unrealized gain (loss) on available-for-sale securities, net of tax:		2		(3)		3		48		(49)		4		3		(2)
Comprehensive loss	$	(8,951)	$	(10,764)	$	(9,160)	$	(8,620)	$	(8,752)	$	(7,482)	$	(6,177)	$	(3,200)
Net loss per share
Basic and diluted net loss per share	$	(0.51)	$	(0.64)	$	(0.54)	$	(0.51)	$	(0.53)	$	(0.52)	$	(0.43)	$	(0.23)
Weighted average shares used to compute net loss per common share — basic and diluted		17,656		16,927		16,881		16,842		16,574		14,381		14,233		13,803