X0508 4 2026-02-18 0001625101 PULSE BIOSCIENCES, INC. PLSE 0001913245 Danahy Kevin Patrick C/O PULSE BIOSCIENCES, INC. 3957 POINT EDEN WAY HAYWARD CA 94545 1 Chief Commercial Officer 1 Common Stock 2026-02-18 4 M 0 5000 1.53 A 48298 D Common Stock 2026-02-18 4 S 0 5000 23.64 D 43298 D Stock Option (right to buy) 1.53 2026-02-18 4 M 0 5000 0 D 2032-09-23 Common Stock 5000 300000 D These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 14, 2025. The price in column 4 is the weighted average price per share sold. The price per share actually received by the reporting person ranged from $22.40 to $24.40 per share. For all transactions reported in this Form 4 using a weighted average price, the reporting person undertakes upon request by the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares sold at each separate price within the range. Options granted on September 23, 2022, to acquire up to 450,000 shares of Common Stock, in connection with reporting person's promotion, with 25% vesting on each anniversary of grant, pursuant to the terms of an amendment to reporting person's Employment Agreement dated February 9, 2022. /s/ Kenneth B. Stratton, as Attorney-in-Fact 2026-02-23