Note 8 - Income Taxes - Reconciliation of Provision for Income Taxes (Details)	12 Months Ended
	Dec. 31, 2024	Dec. 31, 2023
Federal tax at statutory rate	21.00%	21.00%
Research and development credits	2.20%	3.70%
Return to provision	(0.30%)	2.60%
Change in valuation allowance	(21.80%)	(19.10%)
Deferred adjustment	0.00%	(1.60%)
Change in tax rate	0.00%	(5.80%)
Other	(1.10%)	(0.80%)
Provision for income taxes	0.00%	0.00%