Stockholders' Equity - Additional Information (Details) - USD ($) $ / shares in Units, $ in Thousands				1 Months Ended	3 Months Ended
	May 03, 2022	Dec. 31, 2021	Jul. 16, 2021	May 16, 2022	Mar. 31, 2022	Mar. 31, 2021	May 31, 2022	May 09, 2022	May 05, 2022
Class of Stock [Line Items]
Net proceeds after deducting offering costs					$ 3,944	$ 11,703
Each warrant exercisable shares		10,687,912			10,687,912
Exercise price of warrants		$ 1.26			$ 1.26
Common stock, voting rights					one vote for each share held
Preferred stock issued		0			0
Preferred stock stated value per share		$ 0.001			$ 0.001
At Market Issuance Sales Agreement
Class of Stock [Line Items]
Issuance of common stock, net of issuance costs, shares			4,081,338
Securities Purchase Agreement | Subsequent Event
Class of Stock [Line Items]
Preferred stock issued	2,872.1376
Preferred stock stated value per share	$ 1,000
Conversion price	0.16
Warrants Expire on July 16, 2026
Class of Stock [Line Items]
Exercise price of warrants					$ 1.25
Warrants exercisable shares					10,678,872
Warrants expiration date					Jul. 16, 2026
Warrants Expire on May 1, 2026
Class of Stock [Line Items]
Exercise price of warrants					$ 11.06
Warrants exercisable shares					9,040
Warrants expiration date					May 01, 2026
Common Warrants | Subsequent Event
Class of Stock [Line Items]
Exercise price of warrants	$ 0.1694						$ 0.1694
Warrant issued	22,438,575
Warrant term	5 years
Number of warrants issued				22,438,575
HCW Warrants | Subsequent Event
Class of Stock [Line Items]
Exercise price of warrants	$ 0.20						$ 0.20
Warrants expiration date				May 03, 2027
Warrant issued	1,256,561
Warrant term	5 years
Number of warrants issued				1,256,561
Direct Offering
Class of Stock [Line Items]
Issuance of common stock, net of issuance costs, shares			17,416,096
Maximum aggregate warrant to purchase number of shares of common stock			10,678,872
Combined price of each share of common stock and accompanying warrant to purchase one-half price per share			$ 1.311
Net proceeds after deducting offering costs			$ 25,400
Difference in combined price of each share of common stock and accompanying warrant and purchase price of prefunded warrant per share			$ 0.01
Gross proceeds of the transaction			$ 28,000
Each warrant exercisable shares			1
Warrant exercisable date			Jul. 16, 2026
Exercise price of warrants			$ 1.25
Direct Offering | 2021 Pre-Funded Warrant
Class of Stock [Line Items]
Maximum aggregate warrant to purchase number of shares of common stock			3,941,648
Purchase price of warrant			$ 1.301
Each warrant exercisable shares			1
Warrant exercisable date			Jul. 16, 2021
Exercise price of warrants			$ 0.01
Series D and E Convertible Preferred Stock | Securities Purchase Agreement | Subsequent Event
Class of Stock [Line Items]
Preferred stock issued	2,872.1376
Net proceeds from issuance and sale of preferred stock	$ 2,300
Preferred stock stated value per share	$ 1,000
Series D Preferred Stock | Securities Purchase Agreement | Subsequent Event
Class of Stock [Line Items]
Preferred stock stated value per share	$ 0.001
Conversion of preferred stock	8,975,430								8,975,430
Conversion price	$ 0.16
Series E Preferred Stock | Securities Purchase Agreement | Subsequent Event
Class of Stock [Line Items]
Preferred stock stated value per share	$ 0.001
Conversion of preferred stock	8,975,430							8,975,430
Conversion price	$ 0.16
Cowen ATM Agreement
Class of Stock [Line Items]
Issuance of common stock, net of issuance costs, shares						6,058,318
Net proceeds after deducting offering costs						$ 11,700
Weighted average price of common stock shares sold and issued						$ 1.99
B. Riley ATM Agreement | At Market Issuance Sales Agreement
Class of Stock [Line Items]
Net proceeds after deducting offering costs		$ 4,200
Weighted average price of common stock shares sold and issued		$ 1.11
Updated B. Riley ATM Agreement. | At Market Issuance Sales Agreement
Class of Stock [Line Items]
Issuance of common stock, net of issuance costs, shares					6,804,888
Net proceeds after deducting offering costs					$ 4,100
Weighted average price of common stock shares sold and issued					$ 0.62