X0206 3 2017-11-01 0 0001624658 Allena Pharmaceuticals, Inc. ALNA 0001192595 TEPPER ROBERT I C/O THIRD ROCK VENTURES, LLC 29 NEWBURY STREET, 3RD FLOOR BOSTON MA 02116 1 0 1 0 Stock Option (Right to Buy) 5.72 2027-09-26 Common Stock 20364 D Series A Preferred Stock Common Stock 1466805 I See Footnote Series B Preferred Stock Common Stock 1109159 I See Footnote These shares will vest annually over a 3 (three) year period beginning on September 26, 2018. Each share of Series A Convertible Preferred Stock is convertible into Common Stock on a 4.174-for-one basis at any time at the holder's election, and automatically upon the closing of the Issuer's initial public offering, and has no expiration date. These shares are directly held by Third Rock Ventures II, L.P. ("TRV II"). The general partner of TRV II is Third Rock Ventures GP II, L.P. ("TRV GP II"). The general partner of TRV GP II is TRV GP II, LLC ("TRV GP II LLC"). The individual managers of TRV GP II LLC are Mark Levin ("Levin"), Kevin Starr ("Starr") and Dr. Robert Tepper ("Tepper"). Each of TRV GP II, TRV GP II LLC, Levin, Starr and Tepper disclaims beneficial ownership of these shares except to the extent of its or his pecuniary interest therein, if any, and this report shall not be deemed an admission that it or he is the beneficial owner of such shares. Each share of Series B Convertible Preferred Stock is convertible into Common Stock on a 4.174-for-one basis at any time at the holder's election, and automatically upon the closing of the Issuer's initial public offering, and has no expiration date. /s/ Kevin Brennan, attorney-in-fact 2017-11-01