<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0002106698</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001624322</issuerCik>
      <issuerName>Business First Bancshares, Inc.</issuerName>
      <secFileNumber>001-38447</secFileNumber>
      <issuerAddress>
        <com:street1>500 LAUREL STREET</com:street1>
        <com:street2>SUITE 101</com:street2>
        <com:city>BATON ROUGE</com:city>
        <com:stateOrCountry>LA</com:stateOrCountry>
        <com:zipCode>70801</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>225-248-7600</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Cummings George W. III</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Director</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Raymond James &amp; Associates</name>
        <address>
          <com:street1>880 Carillon Parkway </com:street1>
          <com:city>St. Petersburg</com:city>
          <com:stateOrCountry>FL</com:stateOrCountry>
          <com:zipCode>33716</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>20000</noOfUnitsSold>
      <aggregateMarketValue>560055.64</aggregateMarketValue>
      <noOfUnitsOutstanding>29615370</noOfUnitsOutstanding>
      <approxSaleDate>02/25/2026</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>01/01/2026</acquiredDate>
      <natureOfAcquisitionTransaction>Merger with Progressive Bancorp</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>20000</amountOfSecuritiesAcquired>
      <paymentDate>01/01/2026</paymentDate>
      <natureOfPayment>N/A</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>02/25/2026</noticeDate>
      <signature>Maressia Rooks-Bailey, as duly authorized representative of Raymond James &amp; Associates, Inc., as attorney-in-fact for George W Cummings III</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
