<?xml version="1.0" encoding="UTF-8"?><ns2:edgarSubmission xmlns:com="http://www.sec.gov/edgar/common" xmlns:ns2="http://www.sec.gov/edgar/ownership">
    <ns2:headerData>
        <ns2:submissionType>144</ns2:submissionType>
        <ns2:filerInfo>
            <ns2:filer>
                <ns2:filerCredentials>
                    <ns2:cik>0002106698</ns2:cik>
                    <ns2:ccc>XXXXXXXX</ns2:ccc>
                </ns2:filerCredentials>
            </ns2:filer>
            <ns2:liveTestFlag>LIVE</ns2:liveTestFlag>



        </ns2:filerInfo>
    </ns2:headerData>
    <ns2:formData>
        <ns2:issuerInfo>
            <ns2:issuerCik>0001624322</ns2:issuerCik>
            <ns2:issuerName>Business First Bancshares, Inc.</ns2:issuerName>
            <ns2:secFileNumber>001-38447</ns2:secFileNumber>
            <ns2:issuerAddress>
                <com:street1>500 Laurel Street</com:street1>
                <com:street2>Suite 101</com:street2>
                <com:city>Baton Rouge</com:city>
                <com:stateOrCountry>LA</com:stateOrCountry>
                <com:zipCode>70801</com:zipCode>
            </ns2:issuerAddress>
            <ns2:issuerContactPhone>1-225-248-7600</ns2:issuerContactPhone>
            <ns2:nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>George W. Cummings</ns2:nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <ns2:relationshipsToIssuer>
                <ns2:relationshipToIssuer>Director</ns2:relationshipToIssuer>
            </ns2:relationshipsToIssuer>
        </ns2:issuerInfo>
        <ns2:securitiesInformation>
            <ns2:securitiesClassTitle>Common Shares</ns2:securitiesClassTitle>
            <ns2:brokerOrMarketmakerDetails>
                <ns2:name>Goldman Sachs &amp; Co. LLC</ns2:name>
                <ns2:address>
                    <com:street1>200 West Street</com:street1>
                    <com:city>New York</com:city>
                    <com:stateOrCountry>NY</com:stateOrCountry>
                    <com:zipCode>10282</com:zipCode>
                </ns2:address>
            </ns2:brokerOrMarketmakerDetails>
            <ns2:noOfUnitsSold>2435</ns2:noOfUnitsSold>
            <ns2:aggregateMarketValue>76215.5</ns2:aggregateMarketValue>
            <ns2:noOfUnitsOutstanding>32549883</ns2:noOfUnitsOutstanding>
            <ns2:approxSaleDate>08/24/2026</ns2:approxSaleDate>
            <ns2:securitiesExchangeName>NASD</ns2:securitiesExchangeName>
        </ns2:securitiesInformation>
        <ns2:securitiesToBeSold>
            <ns2:securitiesClassTitle>Common Shares</ns2:securitiesClassTitle>
            <ns2:acquiredDate>02/26/2008</ns2:acquiredDate>
            <ns2:natureOfAcquisitionTransaction>Acquired from issuer in private transaction</ns2:natureOfAcquisitionTransaction>
            <ns2:nameOfPersonfromWhomAcquired>Issuer</ns2:nameOfPersonfromWhomAcquired>
            <ns2:isGiftTransaction>N</ns2:isGiftTransaction>
            <ns2:amountOfSecuritiesAcquired>583</ns2:amountOfSecuritiesAcquired>
            <ns2:paymentDate>02/26/2008</ns2:paymentDate>
            <ns2:natureOfPayment>None</ns2:natureOfPayment>
        </ns2:securitiesToBeSold>
        <ns2:securitiesToBeSold>
            <ns2:securitiesClassTitle>Common Shares</ns2:securitiesClassTitle>
            <ns2:acquiredDate>11/03/2008</ns2:acquiredDate>
            <ns2:natureOfAcquisitionTransaction>Acquired from issuer in private transaction</ns2:natureOfAcquisitionTransaction>
            <ns2:nameOfPersonfromWhomAcquired>Issuer</ns2:nameOfPersonfromWhomAcquired>
            <ns2:isGiftTransaction>N</ns2:isGiftTransaction>
            <ns2:amountOfSecuritiesAcquired>583</ns2:amountOfSecuritiesAcquired>
            <ns2:paymentDate>11/03/2008</ns2:paymentDate>
            <ns2:natureOfPayment>None</ns2:natureOfPayment>
        </ns2:securitiesToBeSold>
        <ns2:securitiesToBeSold>
            <ns2:securitiesClassTitle>Common Shares</ns2:securitiesClassTitle>
            <ns2:acquiredDate>12/03/2007</ns2:acquiredDate>
            <ns2:natureOfAcquisitionTransaction>Acquired from issuer in private transaction</ns2:natureOfAcquisitionTransaction>
            <ns2:nameOfPersonfromWhomAcquired>Issuer</ns2:nameOfPersonfromWhomAcquired>
            <ns2:isGiftTransaction>N</ns2:isGiftTransaction>
            <ns2:amountOfSecuritiesAcquired>557</ns2:amountOfSecuritiesAcquired>
            <ns2:paymentDate>12/03/2007</ns2:paymentDate>
            <ns2:natureOfPayment>None</ns2:natureOfPayment>
        </ns2:securitiesToBeSold>
        <ns2:securitiesToBeSold>
            <ns2:securitiesClassTitle>Common Shares</ns2:securitiesClassTitle>
            <ns2:acquiredDate>09/01/2005</ns2:acquiredDate>
            <ns2:natureOfAcquisitionTransaction>Acquired from issuer in private transaction</ns2:natureOfAcquisitionTransaction>
            <ns2:nameOfPersonfromWhomAcquired>Issuer</ns2:nameOfPersonfromWhomAcquired>
            <ns2:isGiftTransaction>N</ns2:isGiftTransaction>
            <ns2:amountOfSecuritiesAcquired>497</ns2:amountOfSecuritiesAcquired>
            <ns2:paymentDate>09/01/2005</ns2:paymentDate>
            <ns2:natureOfPayment>None</ns2:natureOfPayment>
        </ns2:securitiesToBeSold>
        <ns2:securitiesToBeSold>
            <ns2:securitiesClassTitle>Common Shares</ns2:securitiesClassTitle>
            <ns2:acquiredDate>03/06/2007</ns2:acquiredDate>
            <ns2:natureOfAcquisitionTransaction>Acquired from issuer in private transaction</ns2:natureOfAcquisitionTransaction>
            <ns2:nameOfPersonfromWhomAcquired>Issuer</ns2:nameOfPersonfromWhomAcquired>
            <ns2:isGiftTransaction>N</ns2:isGiftTransaction>
            <ns2:amountOfSecuritiesAcquired>215</ns2:amountOfSecuritiesAcquired>
            <ns2:paymentDate>03/06/2007</ns2:paymentDate>
            <ns2:natureOfPayment>None</ns2:natureOfPayment>
        </ns2:securitiesToBeSold>
        <ns2:nothingToReportFlagOnSecuritiesSoldInPast3Months>N</ns2:nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <ns2:securitiesSoldInPast3Months>
            <ns2:sellerDetails>
                <ns2:name>George W. Cummings</ns2:name>
                <ns2:address>
                    <com:street1>500 Laurel Street</com:street1>
                    <com:street2>Suite 101</com:street2>
                    <com:city>Baton Rouge</com:city>
                    <com:stateOrCountry>LA</com:stateOrCountry>
                    <com:zipCode>70801</com:zipCode>
                </ns2:address>
            </ns2:sellerDetails>
            <ns2:securitiesClassTitle>Common Shares</ns2:securitiesClassTitle>
            <ns2:saleDate>05/27/2026</ns2:saleDate>
            <ns2:amountOfSecuritiesSold>11595</ns2:amountOfSecuritiesSold>
            <ns2:grossProceeds>323358.17</ns2:grossProceeds>
        </ns2:securitiesSoldInPast3Months>
        <ns2:securitiesSoldInPast3Months>
            <ns2:sellerDetails>
                <ns2:name>George W. Cummings</ns2:name>
                <ns2:address>
                    <com:street1>500 Laurel Street</com:street1>
                    <com:street2>Suite 101</com:street2>
                    <com:city>Baton Rouge</com:city>
                    <com:stateOrCountry>LA</com:stateOrCountry>
                    <com:zipCode>70801</com:zipCode>
                </ns2:address>
            </ns2:sellerDetails>
            <ns2:securitiesClassTitle>Common Shares</ns2:securitiesClassTitle>
            <ns2:saleDate>06/08/2026</ns2:saleDate>
            <ns2:amountOfSecuritiesSold>15000</ns2:amountOfSecuritiesSold>
            <ns2:grossProceeds>427713.17</ns2:grossProceeds>
        </ns2:securitiesSoldInPast3Months>
        <ns2:securitiesSoldInPast3Months>
            <ns2:sellerDetails>
                <ns2:name>George W. Cummings</ns2:name>
                <ns2:address>
                    <com:street1>500 Laurel Street</com:street1>
                    <com:street2>Suite 101</com:street2>
                    <com:city>Baton Rouge</com:city>
                    <com:stateOrCountry>LA</com:stateOrCountry>
                    <com:zipCode>70801</com:zipCode>
                </ns2:address>
            </ns2:sellerDetails>
            <ns2:securitiesClassTitle>Common Shares</ns2:securitiesClassTitle>
            <ns2:saleDate>06/09/2026</ns2:saleDate>
            <ns2:amountOfSecuritiesSold>445</ns2:amountOfSecuritiesSold>
            <ns2:grossProceeds>12918.93</ns2:grossProceeds>
        </ns2:securitiesSoldInPast3Months>
        <ns2:securitiesSoldInPast3Months>
            <ns2:sellerDetails>
                <ns2:name>George W. Cummings</ns2:name>
                <ns2:address>
                    <com:street1>500 Laurel Street</com:street1>
                    <com:street2>Suite 101</com:street2>
                    <com:city>Baton Rouge</com:city>
                    <com:stateOrCountry>LA</com:stateOrCountry>
                    <com:zipCode>70801</com:zipCode>
                </ns2:address>
            </ns2:sellerDetails>
            <ns2:securitiesClassTitle>Common Shares</ns2:securitiesClassTitle>
            <ns2:saleDate>06/10/2026</ns2:saleDate>
            <ns2:amountOfSecuritiesSold>15000</ns2:amountOfSecuritiesSold>
            <ns2:grossProceeds>432927.07</ns2:grossProceeds>
        </ns2:securitiesSoldInPast3Months>
        <ns2:securitiesSoldInPast3Months>
            <ns2:sellerDetails>
                <ns2:name>George W. Cummings</ns2:name>
                <ns2:address>
                    <com:street1>500 Laurel Street</com:street1>
                    <com:street2>Suite 101</com:street2>
                    <com:city>Baton Rouge</com:city>
                    <com:stateOrCountry>LA</com:stateOrCountry>
                    <com:zipCode>70801</com:zipCode>
                </ns2:address>
            </ns2:sellerDetails>
            <ns2:securitiesClassTitle>Common Shares</ns2:securitiesClassTitle>
            <ns2:saleDate>06/11/2026</ns2:saleDate>
            <ns2:amountOfSecuritiesSold>5000</ns2:amountOfSecuritiesSold>
            <ns2:grossProceeds>143768.03</ns2:grossProceeds>
        </ns2:securitiesSoldInPast3Months>
        <ns2:securitiesSoldInPast3Months>
            <ns2:sellerDetails>
                <ns2:name>George W. Cummings</ns2:name>
                <ns2:address>
                    <com:street1>500 Laurel Street</com:street1>
                    <com:street2>Suite 101</com:street2>
                    <com:city>Baton Rouge</com:city>
                    <com:stateOrCountry>LA</com:stateOrCountry>
                    <com:zipCode>70801</com:zipCode>
                </ns2:address>
            </ns2:sellerDetails>
            <ns2:securitiesClassTitle>Common Shares</ns2:securitiesClassTitle>
            <ns2:saleDate>07/28/2026</ns2:saleDate>
            <ns2:amountOfSecuritiesSold>10000</ns2:amountOfSecuritiesSold>
            <ns2:grossProceeds>318344.43</ns2:grossProceeds>
        </ns2:securitiesSoldInPast3Months>
        <ns2:securitiesSoldInPast3Months>
            <ns2:sellerDetails>
                <ns2:name>George W. Cummings</ns2:name>
                <ns2:address>
                    <com:street1>500 Laurel Street</com:street1>
                    <com:street2>Suite 101</com:street2>
                    <com:city>Baton Rouge</com:city>
                    <com:stateOrCountry>LA</com:stateOrCountry>
                    <com:zipCode>70801</com:zipCode>
                </ns2:address>
            </ns2:sellerDetails>
            <ns2:securitiesClassTitle>Common Shares</ns2:securitiesClassTitle>
            <ns2:saleDate>07/29/2026</ns2:saleDate>
            <ns2:amountOfSecuritiesSold>10000</ns2:amountOfSecuritiesSold>
            <ns2:grossProceeds>318533.43</ns2:grossProceeds>
        </ns2:securitiesSoldInPast3Months>
        <ns2:securitiesSoldInPast3Months>
            <ns2:sellerDetails>
                <ns2:name>George W. Cummings</ns2:name>
                <ns2:address>
                    <com:street1>500 Laurel Street</com:street1>
                    <com:street2>Suite 101</com:street2>
                    <com:city>Baton Rouge</com:city>
                    <com:stateOrCountry>LA</com:stateOrCountry>
                    <com:zipCode>70801</com:zipCode>
                </ns2:address>
            </ns2:sellerDetails>
            <ns2:securitiesClassTitle>Common Shares</ns2:securitiesClassTitle>
            <ns2:saleDate>07/30/2026</ns2:saleDate>
            <ns2:amountOfSecuritiesSold>10000</ns2:amountOfSecuritiesSold>
            <ns2:grossProceeds>320490.39</ns2:grossProceeds>
        </ns2:securitiesSoldInPast3Months>
        <ns2:securitiesSoldInPast3Months>
            <ns2:sellerDetails>
                <ns2:name>George W. Cummings</ns2:name>
                <ns2:address>
                    <com:street1>500 Laurel Street</com:street1>
                    <com:street2>Suite 101</com:street2>
                    <com:city>Baton Rouge</com:city>
                    <com:stateOrCountry>LA</com:stateOrCountry>
                    <com:zipCode>70801</com:zipCode>
                </ns2:address>
            </ns2:sellerDetails>
            <ns2:securitiesClassTitle>Common Shares</ns2:securitiesClassTitle>
            <ns2:saleDate>07/31/2026</ns2:saleDate>
            <ns2:amountOfSecuritiesSold>10000</ns2:amountOfSecuritiesSold>
            <ns2:grossProceeds>314681.51</ns2:grossProceeds>
        </ns2:securitiesSoldInPast3Months>
        <ns2:securitiesSoldInPast3Months>
            <ns2:sellerDetails>
                <ns2:name>George W. Cummings</ns2:name>
                <ns2:address>
                    <com:street1>500 Laurel Street</com:street1>
                    <com:street2>Suite 101</com:street2>
                    <com:city>Baton Rouge</com:city>
                    <com:stateOrCountry>LA</com:stateOrCountry>
                    <com:zipCode>70801</com:zipCode>
                </ns2:address>
            </ns2:sellerDetails>
            <ns2:securitiesClassTitle>Common Shares</ns2:securitiesClassTitle>
            <ns2:saleDate>08/03/2026</ns2:saleDate>
            <ns2:amountOfSecuritiesSold>10000</ns2:amountOfSecuritiesSold>
            <ns2:grossProceeds>318434.43</ns2:grossProceeds>
        </ns2:securitiesSoldInPast3Months>
        <ns2:securitiesSoldInPast3Months>
            <ns2:sellerDetails>
                <ns2:name>George W. Cummings</ns2:name>
                <ns2:address>
                    <com:street1>500 Laurel Street</com:street1>
                    <com:street2>Suite 101</com:street2>
                    <com:city>Baton Rouge</com:city>
                    <com:stateOrCountry>LA</com:stateOrCountry>
                    <com:zipCode>70801</com:zipCode>
                </ns2:address>
            </ns2:sellerDetails>
            <ns2:securitiesClassTitle>Common Shares</ns2:securitiesClassTitle>
            <ns2:saleDate>08/18/2026</ns2:saleDate>
            <ns2:amountOfSecuritiesSold>10000</ns2:amountOfSecuritiesSold>
            <ns2:grossProceeds>317487.45</ns2:grossProceeds>
        </ns2:securitiesSoldInPast3Months>
        <ns2:securitiesSoldInPast3Months>
            <ns2:sellerDetails>
                <ns2:name>George W. Cummings</ns2:name>
                <ns2:address>
                    <com:street1>500 Laurel Street</com:street1>
                    <com:street2>Suite 101</com:street2>
                    <com:city>Baton Rouge</com:city>
                    <com:stateOrCountry>LA</com:stateOrCountry>
                    <com:zipCode>70801</com:zipCode>
                </ns2:address>
            </ns2:sellerDetails>
            <ns2:securitiesClassTitle>Common Shares</ns2:securitiesClassTitle>
            <ns2:saleDate>08/19/2026</ns2:saleDate>
            <ns2:amountOfSecuritiesSold>3235</ns2:amountOfSecuritiesSold>
            <ns2:grossProceeds>102766.71</ns2:grossProceeds>
        </ns2:securitiesSoldInPast3Months>
        <ns2:securitiesSoldInPast3Months>
            <ns2:sellerDetails>
                <ns2:name>George W. Cummings</ns2:name>
                <ns2:address>
                    <com:street1>500 Laurel Street</com:street1>
                    <com:street2>Suite 101</com:street2>
                    <com:city>Baton Rouge</com:city>
                    <com:stateOrCountry>LA</com:stateOrCountry>
                    <com:zipCode>70801</com:zipCode>
                </ns2:address>
            </ns2:sellerDetails>
            <ns2:securitiesClassTitle>Common Shares</ns2:securitiesClassTitle>
            <ns2:saleDate>08/21/2026</ns2:saleDate>
            <ns2:amountOfSecuritiesSold>4200</ns2:amountOfSecuritiesSold>
            <ns2:grossProceeds>131184.71</ns2:grossProceeds>
        </ns2:securitiesSoldInPast3Months>
        <ns2:securitiesSoldInPast3Months>
            <ns2:sellerDetails>
                <ns2:name>George W. Cummings</ns2:name>
                <ns2:address>
                    <com:street1>500 Laurel Street</com:street1>
                    <com:street2>Suite 101</com:street2>
                    <com:city>Baton Rouge</com:city>
                    <com:stateOrCountry>LA</com:stateOrCountry>
                    <com:zipCode>70801</com:zipCode>
                </ns2:address>
            </ns2:sellerDetails>
            <ns2:securitiesClassTitle>Common Shares</ns2:securitiesClassTitle>
            <ns2:saleDate>08/24/2026</ns2:saleDate>
            <ns2:amountOfSecuritiesSold>7565</ns2:amountOfSecuritiesSold>
            <ns2:grossProceeds>236758.43</ns2:grossProceeds>
        </ns2:securitiesSoldInPast3Months>
        <ns2:noticeSignature>
            <ns2:noticeDate>08/24/2026</ns2:noticeDate>
            <ns2:planAdoptionDates/>
            <ns2:signature>Goldman Sachs &amp; Co. LLC on behalf of George W. Cummings</ns2:signature>
        </ns2:noticeSignature>
    </ns2:formData>
</ns2:edgarSubmission>
