X0508 4 2023-12-01 0 0001623526 Stoke Therapeutics, Inc. STOK 0001360548 Tulipano Stephen J C/O STOKE THERAPEUTICS, INC. 45 WIGGINS AVENUE BEDFORD MA 01730 0 1 0 0 CFO 0 Employee Stock Option (Right to Buy) 20.25 2023-12-01 4 D 0 60000 D 2030-03-24 Common Stock 60000 0 D Employee Stock Option (Right to Buy) 60.00 2023-12-01 4 D 0 65600 D 2031-03-01 Common Stock 65600 0 D Employee Stock Option (Right to Buy) 20.34 2023-12-01 4 D 0 107400 D 2032-03-14 Common Stock 107400 0 D Restricted Stock Unit (RSU) 2023-12-01 4 A 0 60773 0.00 A 2025-12-01 Common Stock 60773 60773 D The canceled option vested as to 1/48th of the total award on April 25, 2020 and provided for 1/48th of the total award to vest monthly thereafter, subject to the reporting person's continued service to the Issuer through each vesting date. On December 1, 2023, the Issuer cancelled, pursuant to the Issuer's option exchange program, options to purchase 60,000 shares of Common Stock of the Issuer and in exchange issued to the reporting person 18,749 restricted stock units. The canceled option vested as to 1/48th of the total award on April 2, 2021 and provided for 1/48th of the total award to vest monthly thereafter, subject to the reporting person's continued service to the Issuer through each vesting date. On December 1, 2023, the Issuer cancelled, pursuant to the Issuer's option exchange program, options to purchase 65,600 shares of Common Stock of the Issuer and in exchange issued to the reporting person 8,463 restricted stock units. The canceled option vested as to 1/48th of the total award on April 15, 2022 and provided for 1/48th of the total award to vest monthly thereafter, subject to the reporting person's continued service to the Issuer through each vesting date. On December 1, 2023, the Issuer cancelled, pursuant to the Issuer's option exchange program, options to purchase 107,400 shares of Common Stock of the Issuer and in exchange issued to the reporting person 33,561 restricted stock units. Each restricted stock unit represents a contingent right to receive one share of the Issuer's Common Stock. 48,792 restricted stock units will vest on December 1, 2024 and 11,981 will vest on December 1, 2025, subject to the reporting person's continued service to the Issuer on each such date. /s/ Stephen Tulipano 2023-12-05