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  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001623049</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001116463</issuerCik>
      <issuerName>ORASURE TECHNOLOGIES INC</issuerName>
      <secFileNumber>001-16537</secFileNumber>
      <issuerAddress>
        <com:street1>220 East First Street</com:street1>
        <com:city>Bethlehem</com:city>
        <com:stateOrCountry>PA</com:stateOrCountry>
        <com:zipCode>18015-1360</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>5036416115</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Mara Aspinall</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Board</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>MERRILL LYNCH</name>
        <address>
          <com:street1>45 WILLIAM STREET</com:street1>
          <com:city>WELLESLEY</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02481</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>89716</noOfUnitsSold>
      <aggregateMarketValue>225000</aggregateMarketValue>
      <noOfUnitsOutstanding>71733530</noOfUnitsOutstanding>
      <approxSaleDate>12/04/2025</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <acquiredDate>05/14/2024</acquiredDate>
      <natureOfAcquisitionTransaction>STOCK BONUS</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>MARA ASPINALL</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>17898</amountOfSecuritiesAcquired>
      <paymentDate>05/14/2024</paymentDate>
      <natureOfPayment>STOCK</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <acquiredDate>05/15/2023</acquiredDate>
      <natureOfAcquisitionTransaction>STOCK BONUS</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>MARA ASPINALL</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>14600</amountOfSecuritiesAcquired>
      <paymentDate>05/15/2023</paymentDate>
      <natureOfPayment>STOCK</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <acquiredDate>08/25/2022</acquiredDate>
      <natureOfAcquisitionTransaction>STOCK BONUS</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>MARA ASPINALL</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>6000</amountOfSecuritiesAcquired>
      <paymentDate>08/25/2022</paymentDate>
      <natureOfPayment>STOCK</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <acquiredDate>06/03/2022</acquiredDate>
      <natureOfAcquisitionTransaction>STOCK BONUS</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>MARA ASPINALL</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>18238</amountOfSecuritiesAcquired>
      <paymentDate>06/03/2022</paymentDate>
      <natureOfPayment>STOCK</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <acquiredDate>05/16/2022</acquiredDate>
      <natureOfAcquisitionTransaction>STOCK BONUS</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>MARA ASPINALL</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>7995</amountOfSecuritiesAcquired>
      <paymentDate>05/16/2022</paymentDate>
      <natureOfPayment>STOCK</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <acquiredDate>05/17/2021</acquiredDate>
      <natureOfAcquisitionTransaction>STOCK BONUS</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>MARA ASPINALL</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>4802</amountOfSecuritiesAcquired>
      <paymentDate>05/17/2021</paymentDate>
      <natureOfPayment>STOCK</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <acquiredDate>05/15/2020</acquiredDate>
      <natureOfAcquisitionTransaction>STOCK BONUS</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>MARA ASPINALL</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>9039</amountOfSecuritiesAcquired>
      <paymentDate>05/15/2020</paymentDate>
      <natureOfPayment>STOCK</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <acquiredDate>05/20/2019</acquiredDate>
      <natureOfAcquisitionTransaction>STOCK BONUS</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>MARA ASPINALL</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>6144</amountOfSecuritiesAcquired>
      <paymentDate>05/20/2019</paymentDate>
      <natureOfPayment>STOCK</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <acquiredDate>11/07/2017</acquiredDate>
      <natureOfAcquisitionTransaction>STOCK BONUS</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>MARA ASPINALL</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>5000</amountOfSecuritiesAcquired>
      <paymentDate>11/07/2017</paymentDate>
      <natureOfPayment>STOCK</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>12/04/2025</noticeDate>
      <signature>Kelly Von Ahn</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
