X0306 4 2022-05-16 0001116463 ORASURE TECHNOLOGIES INC OSUR 0001623049 Aspinall Mara G. 220 EAST FIRST STREET BETHLEHEM PA 18015 1 0 0 0 Common Stock 2022-05-16 4 F 0 2957 5.25 D 32980 D Common Stock 2022-05-16 4 A 0 20000 5.25 A 52980 D Withholding of shares to pay the tax liability associated with vesting of restricted shares Grant of restricted shares under the OraSure Technologies, Inc. Stock Award Plan, cliff vesting on May 15, 2023. Vesting shall cease immediately if the named individual voluntarily ceases to serve as a member of the Board of Directors. /s/ Michele M. Miller As Attorney-In-Fact for Mara G. Aspinall 2022-05-18