The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBVIE INC COM 00287Y109 2,049 20,867 SH   DFND 1,2,3 20,867 0 0
AIM IMMUNOTECH INC COM 00901B105 72 29,000 SH   DFND 1,2,3 29,000 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106 129 31,000 SH   DFND 1,2,3 31,000 0 0
ALPHABET INC CAP STK CL A 02079K305 85,083 60,000 SH   DFND 1,2,3 60,000 0 0
AMAZON COM INC COM 023135106 82,765 30,000 SH   DFND 1,2,3 30,000 0 0
ANAPTYSBIO INC COM 032724106 448 20,039 SH   DFND 1,2,3 20,039 0 0
APPLE INC COM 037833100 25,996 71,260 SH   DFND 1,2,3 71,260 0 0
APPLE INC COM 037833100 10,944 30,000 SH Put DFND 1,2,3 30,000 0 0
APREA THERAPEUTICS INC COM 03836J102 460 11,863 SH   DFND 1,2,3 11,863 0 0
ARDELYX INC COM 039697107 263 37,952 SH   DFND 1,2,3 37,952 0 0
ASML HOLDING N V N Y REGISTRY SHS N07059210 11,041 30,000 SH   DFND 1,2,3 30,000 0 0
ATARA BIOTHERAPEUTICS INC COM 046513107 545 37,425 SH   DFND 1,2,3 37,425 0 0
AVALONBAY CMNTYS INC COM 053484101 7,732 50,000 SH   DFND 1,2,3 50,000 0 0
AVEO PHARMACEUTICALS INC COM NEW 053588307 147 28,600 SH   DFND 1,2,3 28,600 0 0
BOEING CO COM 097023105 18,330 100,000 SH Call DFND 1,2,3 100,000 0 0
BRAINSTORM CELL THERAPEUTICS COM NEW 10501E201 258 23,000 SH   DFND 1,2,3 23,000 0 0
BLACKROCK INC COM 09247X101 38,086 70,000 SH   DFND 1,2,3 70,000 0 0
BLACKROCK INC COM 09247X101 38,086 70,000 SH Put DFND 1,2,3 70,000 0 0
BLACKSTONE GROUP INC COM CL A 09260d107 22,664 400,000 SH   DFND 1,2,3 400,000 0 0
BLACKSTONE GROUP INC COM CL A 09260D107 22,664 400,000 SH Put DFND 1,2,3 400,000 0 0
CAMDEN PPTY TR SH BEN INT 133131102 1,158 12,700 SH   DFND 1,2,3 12,700 0 0
CARA THERAPEUTICS INC COM 140755109 474 27,715 SH   DFND 1,2,3 27,715 0 0
CEL SCI CORP COM PAR NEW 150837607 492 33,000 SH   DFND 1,2,3 33,000 0 0
CHARLES RIV LABS INTL INC COM 159864107 3,460 19,844 SH   DFND 1,2,3 19,844 0 0
CHEWY INC CL A 16679L109 4,013 89,800 SH   DFND 1,2,3 89,800 0 0
CLOVIS ONCOLOGY INC COM 189464100 479 70,905 SH   DFND 1,2,3 70,905 0 0
COMMUNITY HEALTH SYS INC NEW COM 203668108 82,728 27,484,473 SH   DFND 1,2,3 27,484,473 0 0
CORBUS PHARMACEUTICALS HLDGS COM 21833P103 532 63,371 SH   DFND 1,2,3 63,371 0 0
DIFFUSION PHARMACEUTICALS IN COM PAR 253748305 59 61,000 SH   DFND 1,2,3 61,000 0 0
DISNEY WALT CO COM DISNEY 254687106 22,302 200,000 SH   DFND 1,2,3 200,000 0 0
DISNEY WALT CO COM DISNEY 254687106 11,184 100,300 SH Call DFND 1,2,3 100,300 0 0
EQUITY RESIDENTIAL SH BEN INT 29476L107 1,397 23,750 SH   DFND 1,2,3 23,750 0 0
ESSEX PPTY TR INC COM 297178105 1,925 8,400 SH   DFND 1,2,3 8,400 0 0
FACEBOOK INC CL A 30303M102 22,707 100,000 SH   DFND 1,2,3 100,000 0 0
FACEBOOK INC CL A 30303M102 11,354 50,000 SH Put DFND 1,2,3 50,000 0 0
FARFETCH LTD ORD SH CL A 30744W107 2,147 124,300 SH   DFND 1,2,3 124,300 0 0
GENERAL DYNAMICS CORP COM 369550108 1,913 12,800 SH   DFND 1,2,3 12,800 0 0
GILEAD SCIENCES INC COM 375558103 5,129 66,667 SH   DFND 1,2,3 66,667 0 0
GLAXOSMITHKLINE PLC SPONSORED ADR 37733W105 2,719 66,667 SH   DFND 1,2,3 66,667 0 0
HERCULES CAPITAL INC COM 427096508 42,194 4,029,986 SH   DFND 1,2,3 4,029,986 0 0
ICON PLC SHS G4705A100 2,498 14,826 SH   DFND 1,2,3 14,826 0 0
INFLARX NV COM N44821101 129 28,000 SH   DFND 1,2,3 28,000 0 0
IMMUNOGEN INC COM 45253H101 533 115,875 SH   DFND 1,2,3 115,875 0 0
IQVIA HLDGS INC COM 46266C105 3,797 26,762 SH   DFND 1,2,3 26,762 0 0
IVERIC BIO INC COM 46583P102 352 68,970 SH   DFND 1,2,3 68,970 0 0
JOHNSON & JOHNSON COM 478160104 1,903 13,533 SH   DFND 1,2,3 13,533 0 0
JPMORGAN CHASE & CO COM 46625H100 28,218 300,000 SH   DFND 1,2,3 300,000 0 0
JPMORGAN CHASE & CO COM 46625H100 28,218 300,000 SH Put DFND 1,2,3 300,000 0 0
KALA PHARMACEUTICALS INC COM 483119103 491 46,726 SH   DFND 1,2,3 46,726 0 0
LABORATORY CORP AMER HLDGS COM NEW 50540R409 646 3,891 SH   DFND 1,2,3 3,891 0 0
L3HARRIS TECHNOLOGIES INC COM 502431109 1,697 10,000 SH   DFND 1,2,3 10,000 0 0
LOCKHEED MARTIN CORP COM 539830109 35,580 97,500 SH   DFND 1,2,3 97,500 0 0
LOCKHEED MARTIN CORP COM 539830109 14,159 38,800 SH Call DFND 1,2,3 38,800 0 0
LOCKHEED MARTIN CORP COM 539830109 35,580 97,500 SH Put DFND 1,2,3 97,500 0 0
MASTERCARD INC CL A 57636Q104 20,699 70,000 SH   DFND 1,2,3 70,000 0 0
MASTERCARD INC CL A 57636Q104 17,742 60,000 SH Put DFND 1,2,3 60,000 0 0
MEDPACE HLDGS INC COM 58506Q109 4,044 43,472 SH   DFND 1,2,3 43,472 0 0
MERCADOLIBRE INC COM 58733R102 4,042 4,100 SH   DFND 1,2,3 4,100 0 0
MID-AMER APT CMNTYS INC COM 59522J103 1,674 14,600 SH   DFND 1,2,3 14,600 0 0
MILESTONE PHARMACEUTICALS IN COM 59935V107 98 26,000 SH   DFND 1,2,3 26,000 0 0
MERCK & CO. INC. COM 58933Y105 1,031 13,333 SH   DFND 1,2,3 13,333 0 0
MODERNA INC COM 60770K107 3,853 60,000 SH   DFND 1,2,3 60,000 0 0
NABRIVA THERAPEUTICS PLC SHS G63637105 103 152,000 SH   DFND 1,2,3 152,000 0 0
MINERVA NEUROSCIENCES INC COM 603380106 147 40,600 SH   DFND 1,2,3 40,600 0 0
NETFLIX INC COM 64110L106 9,101 20,000 SH Call DFND 1,2,3 20,000 0 0
NORTHROP GRUMMAN CORP COM 666807102 5,472 17,800 SH   DFND 1,2,3 17,800 0 0
OBSEVA SA COM H5861P103 239 40,500 SH   DFND 1,2,3 40,500 0 0
ONCONOVA THERAPEUTICS INC COM PAR 68232V405 109 192,000 SH   DFND 1,2,3 192,000 0 0
OVID THERAPEUTICS INC COM 690469101 377 51,100 SH   DFND 1,2,3 51,100 0 0
OYSTER PT PHARMA INC COM 69242L106 276 9,559 SH   DFND 1,2,3 9,559 0 0
PFIZER INC COM 717081103 3,270 100,000 SH   DFND 1,2,3 100,000 0 0
PHASEBIO PHARMACEUTICALS INC COM 717224109 140 30,500 SH   DFND 1,2,3 30,500 0 0
PRA HEALTH SCIENCES INC COM 69354M108 851 8,749 SH   DFND 1,2,3 8,749 0 0
PRICE T ROWE GROUP INC COM 74144T108 12,350 100,000 SH   DFND 1,2,3 100,000 0 0
PROVENTION BIO INC COM 74374N102 485 34,341 SH   DFND 1,2,3 34,341 0 0
PLURISTEM THERAPEUTICS INC COM NEW 72940R300 209 23,600 SH   DFND 1,2,3 23,600 0 0
PAYPAL HLDGS INC COM 70450Y103 3,485 20,000 SH   DFND 1,2,3 20,000 0 0
RAYTHEON TECHNOLOGIES CORP COM 75513E101 1,849 30,000 SH   DFND 1,2,3 30,000 0 0
RETROPHIN INC COM 761299106 517 25,342 SH   DFND 1,2,3 25,342 0 0
SEA LTD SPONSORED ADS 81141R100 2,027 18,900 SH   DFND 1,2,3 18,900 0 0
SHOPIFY INC CL A 82509L107 4,936 5,200 SH   DFND 1,2,3 5,200 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105 494 33,300 SH   DFND 1,2,3 33,300 0 0
SPDR S&P 500 ETF TR TR UNIT 78462F103 24,792 80,400 SH Call DFND 1,2,3 80,400 0 0
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 22,708 400,000 SH   DFND 1,2,3 400,000 0 0
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 6,443 113,500 SH Call DFND 1,2,3 113,500 0 0
TESLA INC COM 88160R101 10,798 10,000 SH   DFND 1,2,3 10,000 0 0
UBER TECHNOLOGIES INC COM 90353T100 15,540 500,000 SH   DFND 1,2,3 500,000 0 0
UBER TECHNOLOGIES INC COM 90353T100 15,540 500,000 SH Put DFND 1,2,3 500,000 0 0
UDR INC COM 902653104 1,405 37,600 SH   DFND 1,2,3 37,600 0 0
UNITED PARCEL SERVICE INC CL B 911312106 5,559 50,000 SH   DFND 1,2,3 50,000 0 0
VERASTEM INC COM 92337C104 298 173,000 SH   DFND 1,2,3 173,000 0 0
VISA INC COM CL A 92826C839 48,293 250,000 SH   DFND 1,2,3 250,000 0 0
VISA INC COM CL A 92826C839 12,942 67,000 SH Call DFND 1,2,3 67,000 0 0
VISA INC COM CL A 92826C839 42,497 220,000 SH Put DFND 1,2,3 220,000 0 0
WAYFAIR INC CL A 94419L101 3,853 19,500 SH   DFND 1,2,3 19,500 0 0
WASTE MGMT INC DEL COM 94106L109 10,591 100,000 SH Call DFND 1,2,3 100,000 0 0
WALMART INC COM 931142103 9,223 77,000 SH Call DFND 1,2,3 77,000 0 0
SELECT SECTOR SPDR TR SBI HEALTHCARE 81369Y209 8,006 80,000 SH Call DFND 1,2,3 80,000 0 0
ZOOM VIDEO COMMUNICATIONS IN CL A 98980L101 30,425 120,000 SH   DFND 1,2,3 120,000 0 0