Commitments and Contingencies - Additional Information (Detail)		1 Months Ended	12 Months Ended
	Jul. 06, 2021 USD ($) ft² $ / ft²	Jul. 30, 2020 USD ($)	Dec. 31, 2021 USD ($)	Dec. 31, 2020 USD ($)	Aug. 28, 2020 USD ($)
Commitments And Contingencies Disclosure [Line Items]
Lease expiration month and year			2023-04
Lessee, operating lease, existence of option to extend			true
Operating Lease option to extend			the Company’s option to extend for an additional five-year term.
Right-of-use asset			$ 2,771,000	$ 4,615,000	$ 900,000
Operating lease liabilities			$ 3,155,000		$ 900,000
Plexxikon License Agreement [Member]
Commitments And Contingencies Disclosure [Line Items]
Aggregate payments received progression of on-going clinical studies		$ 2,500,000
License agreement expiration terms			The license agreement will expire on a country-by-country and licensed product-by-licensed product basis until the later of the last to expire of the patents covering such licensed products or services or the 10-year anniversary of the date of first commercial sale of the licensed product in such country. The Company may terminate the license agreement within 30 days after written notice in the event of a material breach. The Company may also terminate the agreement upon written notice in the event of the Company’s bankruptcy, liquidation or insolvency. In addition, the Company has the right to terminate this agreement in its entirety at will upon 90 days’ advance written notice to Plexxikon.
Maximum [Member] | Plexxikon License Agreement [Member]
Commitments And Contingencies Disclosure [Line Items]
Aggregate payments received upon satisfaction of clinical milestones		7,500,000
Aggregate payments received		$ 25,000,000.0
Office and Laboratory Space [Member] | The Boulder Lease [Member]
Commitments And Contingencies Disclosure [Line Items]
Lessee, operating lease, existence of option to extend	true
Operating Lease option to extend	The Company also has the option to extend the Boulder Lease for three successive five-year terms.
Lease deposit			$ 700,000
Area of lease agreement | ft²	38,075
Lease description	Boulder Lease payments will begin upon the earlier of (i) substantial completion of the Improvements or (ii) May 1, 2022. The Company will be entitled to 14 months of free rent, followed by an initial Boulder Lease term of 12 years.
Lease, term of contract	12 years
Base rent initial rate per square foot | $ / ft²	40.00
Rent annual increases percentage	2.50%
Aggregate cost of Improvements to landlord assets	$ 6,900,000
Tenant improvement	$ 2,300,000
Tenant improvement loan annual interest rate	6.00%
Tenant improvement loan repayment term	12 years
Office and Laboratory Space [Member] | The Boulder Lease [Member] | Minimum [Member]
Commitments And Contingencies Disclosure [Line Items]
Construction costs	$ 8,000.0
Office and Laboratory Space [Member] | The Boulder Lease [Member] | Maximum [Member]
Commitments And Contingencies Disclosure [Line Items]
Construction costs	$ 10,000.0
Non-current restricted cash [Member] | Letter of Credit [Member] | Collateral [Member]
Commitments And Contingencies Disclosure [Line Items]
Lease deposit			1,300,000
Other Assets [Member] | Office and Laboratory Space [Member] | The Boulder Lease [Member]
Commitments And Contingencies Disclosure [Line Items]
Payments for construction of lessor assets			$ 1,100,000
SOTIO [Member]
Commitments And Contingencies Disclosure [Line Items]
Percentage of sublease facility			70.00%
SOTIO [Member] | Non-current restricted cash [Member] | Letter of Credit [Member] | Collateral [Member]
Commitments And Contingencies Disclosure [Line Items]
Lease deposit			$ 1,300,000