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Stock-Based Compensation - Schedule of Common Stock Option Activity (Detail) - 2018 Stock Option and Incentive Plan and Inducement Plan [Member]
$ / shares in Units, $ in Thousands
12 Months Ended
Dec. 31, 2021
USD ($)
$ / shares
shares
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]  
Number of Options Outstanding, Beginning balance | shares 3,253,033
Number of Options, Granted | shares 5,967,582
Number of Options, Exercised | shares (15,758)
Number of Options, Forfeited | shares (411,231)
Number of Options Outstanding, Ending balance | shares 8,793,626
Number of Options, Vested and expected to vest | shares 8,793,626
Number of Options, Exercisable | shares 1,354,511
Weighted Average Exercise Price, Outstanding, Beginning balance | $ / shares $ 11.19
Weighted Average Exercise Price, Granted | $ / shares 8.98
Weighted Average Exercise Price, Exercised | $ / shares 1.53
Weighted Average Exercise Price, Forfeited | $ / shares 14.04
Weighted Average Exercise Price, Outstanding, Ending balance | $ / shares 9.57
Weighted Average Exercise Price, Vested and expected to vest | $ / shares 9.57
Weighted Average Exercise Price, Exercisable | $ / shares $ 9.50
Weighted Average Contractual Term, Outstanding, Ending balance 9 years 1 month 6 days
Weighted Average Contractual Term, Vested and expected to vest 9 years 1 month 6 days
Weighted Average Contractual Term, Exercisable 8 years 8 months 12 days
Aggregate Intrinsic Value, Outstanding | $ $ 2,756
Aggregate Intrinsic Value, Vested and expected to vest | $ 2,756
Aggregate Intrinsic Value, Exercisable | $ $ 1,689