Segment Information - Schedule of Segment Information (Detail) - USD ($) $ in Thousands	3 Months Ended				6 Months Ended
	Jun. 30, 2025	Mar. 31, 2025	Jun. 30, 2024	Mar. 31, 2024	Jun. 30, 2025	Jun. 30, 2024
Segment Reporting Information [Line Items]
Operating Expenses	$ (75,582)		$ (64,387)		$ (150,515)	$ (126,791)
Interest income	(2,373)		(5,393)		(5,325)	(9,450)
Interest expense	314				314
Other expense (income), net	6		(44)		11	(43)
Segment net loss and consolidated net loss	73,529	$ 71,986	58,950	$ 58,348	145,515	117,298
Late-stage development [Member]
Segment Reporting Information [Line Items]
Operating Expenses	27,115		28,765		55,212	56,057
Early-stage, preclinical and discovery programs [Member]
Segment Reporting Information [Line Items]
Operating Expenses	10,039		5,562		19,817	12,082
R&D personnel related [Member]
Segment Reporting Information [Line Items]
Operating Expenses	14,568		10,844		29,442	21,524
Research and development software, facilities and other strategic support [Member]
Segment Reporting Information [Line Items]
Operating Expenses	4,907		3,836		9,332	7,057
Other operational infrastructure and advisory support [Member]
Segment Reporting Information [Line Items]
Operating Expenses	8,582		4,762		15,693	9,461
Stock-based compensation expense [Member]
Segment Reporting Information [Line Items]
Operating Expenses	9,716		10,012		19,724	19,405
Depreciation expense [Member]
Segment Reporting Information [Line Items]
Operating Expenses	$ 655		$ 606		$ 1,295	$ 1,205