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Condensed Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
6 Months Ended
Jun. 30, 2022
Jun. 30, 2021
Cash flows from operating activities:    
Net loss $ (65,561) $ (28,277)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization expense 166 31
Stock-based compensation expense 8,709 4,371
Amortization of operating leases, right-of-use assets 1,064 900
Change in fair value of CVR liability   (343)
Changes in operating assets and liabilities:    
Prepaid expenses and other current assets (909) (523)
Other assets (1,168) (1,970)
Accounts payable 9 1,260
Accrued expenses and other current liabilities 3,173 1,666
Operating lease liability (273) (992)
Net cash used in operating activities (54,790) (23,877)
Cash flows from investing activities:    
Purchases of property and equipment (1,585) (123)
Net cash used in investing activities (1,585) (123)
Cash flows from financing activities:    
Proceeds from issuance of shares of common stock and pre-funded warrants, net of offering costs of $10.8 million 162,115  
Proceeds from issuance of stock from employee stock purchase plan 129  
Proceeds from issuance of common stock upon stock option exercises 9  
Payment to CVR Holders   (85)
Net cash (used in) provided by financing activities 162,253 (85)
Net (decrease) increase in cash, cash equivalents and restricted cash 105,878 (24,085)
Cash, cash equivalents and restricted cash at beginning of period 220,939 243,445
Cash, cash equivalents and restricted cash at end of period 326,817 219,360
Supplemental disclosure of cash flow information:    
Right-of-use assets obtained in exchange for new operating lease liabilities 25,184  
Supplemental disclosure of noncash investing and financing information:    
Offering costs included in accounts payable and accrued expenses 200  
Property & equipment included in accounts payable and accrued expenses 466  
Conversion of Series A Convertible Preferred stock into common shares $ 14,000 25,481
Issuance of shares in partial settlement of CVR liability   $ 2,043