Commitments and Contingencies - Additional Information (Detail) $ in Thousands				1 Months Ended		6 Months Ended
	May 05, 2022 $ / ft²	Mar. 19, 2022 ft²	Jul. 06, 2021 USD ($) ft²	Aug. 31, 2020	Jul. 30, 2020 USD ($)	Jun. 30, 2022 USD ($)	May 31, 2022 USD ($)	Mar. 29, 2022 ft²	Dec. 31, 2021 USD ($)
Commitments And Contingencies Disclosure [Line Items]
Lease expiration month and year						2023-04
Operating lease, initial right-of-use asset						$ 26,891			$ 2,771
Operating lease liabilities						28,066
Plexxikon License Agreement [Member]
Commitments And Contingencies Disclosure [Line Items]
Clinical milestone achieved, triggering payment						$ 2,500
License agreement expiration terms						The license agreement will expire on a country-by-country and licensed product-by-licensed product basis until the later of the last to expire of the patents covering such licensed products or services or the 10-year anniversary of the date of first commercial sale of the licensed product in such country. The Company may terminate the license agreement within 30 days after written notice in the event of a material breach. The Company may also terminate the agreement upon written notice in the event of the Company’s bankruptcy, liquidation or insolvency. In addition, the Company has the right to terminate this agreement in its entirety at will upon 90 days’ advance written notice to Plexxikon.
Current restricted cash [Member] | Letter of Credit [Member] | Collateral [Member]
Commitments And Contingencies Disclosure [Line Items]
Security deposit amount						$ 1,300
Maximum [Member] | Plexxikon License Agreement [Member]
Commitments And Contingencies Disclosure [Line Items]
Aggregate payments received upon satisfaction of clinical milestones					$ 7,500
Aggregate payments received					$ 25,000
Waltham Sublease [Member]
Commitments And Contingencies Disclosure [Line Items]
Square feet of office space | ft²		17,749
Sublease term of contract	4 years 4 months
Initial base rent per square foot per year | $ / ft²	42.50
Sublease commencement date	Jun. 01, 2022
Rent annual increase per square foot | $ / ft²	1.00
Operating lease, initial right-of-use asset							$ 2,900
Operating lease liabilities							$ 2,900
Security deposit amount						400
Sublease expiration date	Sep. 30, 2026
Office and Laboratory Space [Member] | The Boulder Lease [Member]
Commitments And Contingencies Disclosure [Line Items]
Lessee, operating lease, existence of option to extend			true
Operating Lease payments description			Boulder Lease payments will begin in June 2023 after an initial free rent period.
Operating lease, initial right-of-use asset			$ 1,100			21,400
Operating lease liabilities			$ 1,100			21,400
Area of lease agreement | ft²			38,075
Aggregate cost of Improvements to landlord assets			$ 6,900
Tenant improvement			$ 2,300
Tenant improvement loan annual interest rate			6.00%
Construction costs			$ 7,000
Additional tenant improvement allowance			600
Additional tenant improvement allowance initial premises			300
Remaining additional tenant improvement allowance			$ 300
Lease description			The Boulder Lease has an initial term of 12 years with the option to extend for three successive five-year terms.
Lease, term of contract			12 years
Security deposit amount						700
Office and Laboratory Space [Member] | First Amendment [Member] | The Boulder Lease [Member]
Commitments And Contingencies Disclosure [Line Items]
Area of lease agreement | ft²								6,582
SOTIO [Member]
Commitments And Contingencies Disclosure [Line Items]
Percentage of sublease facility				70.00%
SOTIO [Member] | Current restricted cash [Member] | Letter of Credit [Member] | Collateral [Member]
Commitments And Contingencies Disclosure [Line Items]
Security deposit amount						$ 1,300