SCHEDULE 13G/A 0000902664-23-003363 0001603466 XXXXXXXX LIVE 4 Common Stock, par value $0.001 per share 09/30/2025 0001622229 Cogent Biosciences, Inc. 19240Q201 275 WYMAN STREET 3RD FLOOR WALTHAM MA 02451 Rule 13d-1(c) Point72 Asset Management, L.P. b DE 0.00 5753833.00 0.00 5753833.00 5753833.00 N 4.0 PN Includes 4,516,000 shares of Common Stock (as defined in Item 2(a)) issuable upon conversion of Series B Non-Voting Preferred Stock (the "Preferred Stock") Point72 Capital Advisors, Inc. b DE 0.00 5753833.00 0.00 5753833.00 5753833.00 N 4.0 CO Includes 4,516,000 shares of Common Stock issuable upon conversion of Preferred Stock Steven A. Cohen b X1 0.00 5753833.00 0.00 5753833.00 5753833.00 N 4.0 IN Includes 4,516,000 shares of Common Stock issuable upon conversion of Preferred Stock Cogent Biosciences, Inc. 275 Wyman Street 3rd Floor Waltham, MA 02451 This statement is filed by: (i) Point72 Asset Management, L.P. ("Point72 Asset Management") with respect to the shares of common stock, par value $0.001 per share ("Common Stock"), of Cogent Biosciences, Inc. (the "Issuer") held by (and shares of Common Stock underlying the Preferred Stock held by) an investment fund it manages; (ii) Point72 Capital Advisors, Inc. ("Point72 Capital Advisors Inc.") with respect to shares of Common Stock held by (and shares of Common Stock underlying the Preferred Stock held by) an investment fund managed by Point72 Asset Management; and (iii) Steven A. Cohen ("Mr. Cohen") with respect to shares of Common Stock beneficially owned by Point72 Asset Management and Point72 Capital Advisors Inc. The address of the principal business office of Point72 Asset Management, Point72 Capital Advisors Inc., and Mr. Cohen is 72 Cummings Point Road, Stamford, CT 06902. Point72 Asset Management is a Delaware limited partnership. Point72 Capital Advisors Inc. is a Delaware corporation. Mr. Cohen is a United States citizen. Y The information required by Item 4(a) is set forth in Row 9 of the cover page for each of the Reporting Persons and is incorporated herein by reference. Such information is as of the close of business on September 30, 2025. Point72 Asset Management, Point72 Capital Advisors Inc., and Mr. Cohen own directly no shares of Common Stock. Pursuant to an investment management agreement, Point72 Asset Management maintains investment and voting power with respect to the securities held by an investment fund it manages. Point72 Capital Advisors Inc. is the general partner of Point72 Asset Management. Mr. Cohen controls each of Point72 Asset Management and Point72 Capital Advisors Inc. The filing of this statement should not be construed as an admission that any of the foregoing persons or any Reporting Person is, for the purposes of Section 13 of the Securities Exchange Act of 1934, the beneficial owner of the shares of Common Stock reported herein. The aggregate percentage of the shares of Common Stock reported to be beneficially owned by each Reporting Person is based on 144,216,796 shares of Common Stock outstanding, which is the sum of: (i) 139,700,796 shares of Common Stock outstanding as of August 1, 2025, as reported in the Issuer's Quarterly Report on Form 10-Q for the quarterly period ended June 30, 2025, filed with the Securities and Exchange Commission on August 5, 2025; and (ii) 4,516,000 shares of Common Stock issuable upon conversion of Preferred Stock as reported herein. 4.0% The information required by Item 4(c)(i) is set forth in Row 5 of the cover page for each of the Reporting Persons and is incorporated herein by reference. Such information is as of the close of business on September 30, 2025. The information required by Item 4(c)(ii) is set forth in Row 6 of the cover page for each of the Reporting Persons and is incorporated herein by reference. Such information is as of the close of business on September 30, 2025. The information required by Item 4(c)(iii) is set forth in Row 7 of the cover page for each of the Reporting Persons and is incorporated herein by reference. Such information is as of the close of business on September 30, 2025. The information required by Item 4(c)(iv) is set forth in Row 8 of the cover page for each of the Reporting Persons and is incorporated herein by reference. Such information is as of the close of business on September 30, 2025. N Y N See Item 2(a). Y Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. Point72 Asset Management, L.P. /s/ Jason M. Colombo 11/14/2025 Point72 Capital Advisors, Inc. /s/ Jason M. Colombo 11/14/2025 Steven A. Cohen /s/ Jason M. Colombo 11/14/2025