SCHEDULE 13D/A 001193125-24-050841 0001622058 XXXXXXXX LIVE 22 Common Stock 03/07/2025 false 0001668397 58506Q109 Medpace Holdings, Inc.

5375 Medpace Way Cincinnati OH 45227

August J. Troendle (513) 579-9911 5375 Medpace Way Cincinnati OH 45227 0001622058 N August J. Troendle b PF N X1 1011102 4733019 1011102 4733019 6018308 N 19.5 IN 0001524599 N Medpace Investors, LLC b OO N DE 0 4733019 0 4733019 4733019 N 15.3 OO (Limited liability company) Common Stock Medpace Holdings, Inc. 5375 Medpace Way Cincinnati OH 45227 This Amendment No. 22 to the Schedule 13D (this "Amendment No. 22") amends and supplements the Statement on Schedule 13D filed with the United States Securities and Exchange Commission on August 26, 2016, as amended by Amendment No. 1 filed on August 8, 2018, Amendment No. 2 filed on October 2, 2018, Amendment No. 3 filed on February 6, 2019, Amendment No. 4 filed on August 5, 2019, Amendment No. 5 filed on August 7, 2019, Amendment No. 6 filed on August 15, 2019, Amendment No. 7 filed on September 17, 2019, Amendment No. 8 filed on May 8, 2020, Amendment No. 9 filed on July 31, 2020, Amendment No. 10 filed on August 14, 2020, Amendment No. 11 filed on December 21, 2020, Amendment No. 12 filed on April 21, 2021, Amendment No. 13 filed on September 1, 2021, Amendment No. 14 filed on December 23, 2021, Amendment No. 15 filed on July 6, 2022, Amendment No. 16 filed on September 13, 2022, Amendment No. 17 filed September 21, 2022, Amendment No. 18 filed September 22, 2023, Amendment No. 19 filed December 5, 2023, Amendment No. 20 filed February 28, 2024, and Amendment No. 21 filed March 8, 2024 (collectively, the "Statement"), relating to the common stock (the "Common Stock"), of Medpace Holdings, Inc., a Delaware corporation (the "Issuer"). Capitalized terms used herein without definition shall have the meaning set forth in the Statement. See Items 7 - 13 of the cover pages above. See Items 7 - 13 of the cover pages above. On March 6, 2025, August J. Troendle was granted 73,443 options that vested immediately. On March 7, 2025, August J. Troendle exercised 356,446 vested stock options as follows: 37,417 exercised at a strike price of $54.74; 234,259 exercised at a strike price of $56.61; and 84,770 exercised at a strike price of $107.93. Except for the transactions reported herein, there have been no other transactions in the Issuer's Common Stock within the last 60 days by the Reporting Persons. Exhibit Description Number 1. Joint Filing Agreement* 2. Registration Rights Agreement* * Filed in the Statement August J. Troendle /s/ August J. Troendle 03/11/2025 Medpace Investors, LLC /s/ August J. Troendle 03/11/2025