Stock-Based Compensation - Stock-Based Compensation Expense (Details) - 2014 Plan - USD ($)	9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021
Stock-Based Compensation
Stock-based compensation	$ 3,310,125	$ 4,769,179
Research and development
Stock-Based Compensation
Stock-based compensation	1,500,447	2,443,667
General and administrative
Stock-Based Compensation
Stock-based compensation	1,809,678	2,325,512
Stock options
Stock-Based Compensation
Stock-based compensation	1,718,130	2,506,336
Stock options | Research and development
Stock-Based Compensation
Stock-based compensation	776,809	1,198,492
Stock options | General and administrative
Stock-Based Compensation
Stock-based compensation	941,321	1,307,844
Restricted stock
Stock-Based Compensation
Stock-based compensation	1,591,995	2,262,843
Restricted stock | Research and development
Stock-Based Compensation
Stock-based compensation	723,638	1,245,175
Restricted stock | General and administrative
Stock-Based Compensation
Stock-based compensation	$ 868,357	$ 1,017,668