X0306 4 2022-07-18 0001621443 Zynerba Pharmaceuticals, Inc. ZYNE 0001327442 Fickenscher James E C/O ZYNERBA PHARMACEUTICALS, INC. 80 W. LANCASTER AVENUE, SUITE 300 DEVON PA 19333 0 1 0 0 Chief Financial Officer Common Stock 2022-07-18 4 A 0 20800 A 178518 D Common Stock 2022-07-19 4 S 0 6013 1.10 D 172505 D On July 18, 2022, the Compensation Committee of the Board of Directors of the Company determined that performance-vesting criteria were met with regard to 20,800 performance-based restricted stock awards granted in a prior year. This transaction represents shares required to be sold by the Reporting Person to satisfy tax obligations and certain equity plan administrator fees in connection with the vesting of shares of restricted stock. This sale was mandated by the equity plan administrator and does not represent a discretionary trade by the Reporting Person. /s/ Albert P. Parker, Attorney-in-Fact 2022-07-20