X0306 4 2022-06-14 0001621443 Zynerba Pharmaceuticals, Inc. ZYNE 0001260426 FEDERICI WILLIAM J C/O ZYNERBA PHARMACEUTICALS, INC. 80 W. LANCASTER AVENUE, SUITE 300 DEVON PA 19333 1 0 0 0 Common Stock 2022-06-14 4 A 0 23109 0 A 28109 D Common Stock 2022-06-14 4 S 0 40 1.01 D 28069 D Stock Option (right to buy) 1.01 2022-06-14 4 A 0 34663 0 A 2032-06-14 Common Stock 34663 34663 D The restricted stock award vests in full upon the earlier of (i) June 14, 2023 or (ii) the day before the Company's 2023 annual meeting of stockholders. This transaction represents shares required to be sold by the Reporting Person to satisfy certain equity plan administrator fees in connection with the vesting of shares of restricted stock. This sale was mandated by the equity plan administrator and does not represent a discretionary trade by the Reporting Person. The option vests in full upon the earlier of (i) June 14, 2023 or (ii) the day before the Company's 2023 annual meeting of stockholders. /s/ Albert P. Parker, Attorney-in-Fact 2022-06-16