X0306 4 2023-01-31 0 0001621443 Zynerba Pharmaceuticals, Inc. ZYNE 0001219866 ANIDO ARMANDO C/O ZYNERBA PHARMACEUTICALS, INC. 80 W. LANCASTER AVENUE, SUITE 300 DEVON 19333 1 1 0 0 Chairman & Chief Exec. Officer Common Stock 2023-01-31 4 A 0 42437 A 868672 D Common Stock 2023-02-01 4 F 0 11726 0.5952 D 856946 D Common Stock 26595 I See footnote Common Stock 13297 I See footnote The restricted stock award was granted in lieu of a portion of a cash bonus earned by the Reporting Person and fully vested as of the grant date. This transaction represents shares required to be sold by the Reporting Person to satisfy tax obligations and certain equity plan administrator fees in connection with the vesting of shares of restricted stock. This sale was mandated by the equity plan administrator and does not represent a discretionary trade by the Reporting Person. TUA of Armando Anido and Nancy J. Anido Trusts are controlled by Armando Anido, who has voting and dispositive power with respect to shares held by the trusts. /s/ Albert P. Parker, Attorney-in-Fact 2023-02-02