144 0001604834 XXXXXXXX LIVE 0001620463 LEONABIO, INC. 001-39503 18706 NORTH CREEK PARKWAY, SUITE 104 BOTHELL WA 98011 (425) 620-8501 Mark James Litton Officer Director Common Morgan Stanley Smith Barney LLC Executive Financial Services

1 New York Plaza 38th Fl. New York NY 10004

5156 27661.94 9300434 03/04/2026 NASDAQ Common 03/03/2026 Restricted Stock Lapse - See Remarks LeonaBio, Inc. N 22254 03/04/2026 Equity Compensation N Mark James Litton

c/o LeonaBio, Inc. 18706 North Creek Parkway, Ste. 104 Bothell WA 98011

Common Stock 01/02/2026 2586 17791.68 Shares sold to cover tax obligation from settlement of vested Restricted Stock Units. 03/04/2026 /s/ Mark Worthington, Attorney-in-Fact for Mark Litton